4PXI
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![BU of 4pxi by Molmil](/molmil-images/mine/4pxi) | Elucidation of the Structural and Functional Mechanism of Action of the TetR Family Protein, CprB from S. coelicolor A3(2) | Descriptor: | CprB, DNA (5'-D(*AP*CP*AP*TP*AP*CP*GP*GP*GP*AP*CP*GP*CP*CP*CP*CP*GP*TP*TP*TP*AP*T)-3'), DNA (5'-D(*AP*TP*AP*AP*AP*CP*GP*GP*GP*GP*CP*GP*TP*CP*CP*CP*GP*TP*AP*TP*GP*T)-3') | Authors: | Hussain, B, Ruchika, B, Aruna, B, Ruchi, A. | Deposit date: | 2014-03-24 | Release date: | 2014-07-02 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural and functional basis of transcriptional regulation by TetR family protein CprB from S. coelicolor A3(2) Nucleic Acids Res., 42, 2014
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4J5S
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![BU of 4j5s by Molmil](/molmil-images/mine/4j5s) | TARG1 (C6orf130), Terminal ADP-ribose Glycohydrolase 1 ADP-ribose complex | Descriptor: | 1,2-ETHANEDIOL, 1,3,2-DIOXABOROLAN-2-OL, BORATE ION, ... | Authors: | Schellenberg, M.J, Appel, C.D, Krahn, J, Williams, R.S. | Deposit date: | 2013-02-09 | Release date: | 2013-03-27 | Last modified: | 2013-07-03 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease. Embo J., 32, 2013
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4J5Q
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![BU of 4j5q by Molmil](/molmil-images/mine/4j5q) | TARG1 (C6orf130), Terminal ADP-ribose Glycohydrolase 1, apo structure | Descriptor: | O-acetyl-ADP-ribose deacetylase 1 | Authors: | Schellenberg, M.J, Appel, C.D, Krahn, J, Williams, R.S. | Deposit date: | 2013-02-09 | Release date: | 2013-03-27 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Deficiency of terminal ADP-ribose protein glycohydrolase TARG1/C6orf130 in neurodegenerative disease. Embo J., 32, 2013
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4K6A
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![BU of 4k6a by Molmil](/molmil-images/mine/4k6a) | Revised Crystal Structure of apo-form of Triosephosphate Isomerase (tpiA) from Escherichia coli at 1.8 Angstrom Resolution. | Descriptor: | SODIUM ION, Triosephosphate isomerase | Authors: | Minasov, G, Kuhn, M, Halavaty, A, Shuvalova, L, Dubrovska, I, Winsor, J, Grimshaw, S, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2013-04-15 | Release date: | 2013-05-01 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural, kinetic and proteomic characterization of acetyl phosphate-dependent bacterial protein acetylation. PLoS ONE, 9, 2014
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7NST
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![BU of 7nst by Molmil](/molmil-images/mine/7nst) | ColicinE9 partial translocation complex | Descriptor: | Colicin-E9, Outer membrane protein F, Tol-Pal system protein TolB | Authors: | Webby, M.N, Kleanthous, C, Lukoyanova, N, Housden, N.G. | Deposit date: | 2021-03-08 | Release date: | 2021-08-11 | Last modified: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Porin threading drives receptor disengagement and establishes active colicin transport through Escherichia coli OmpF. Embo J., 40, 2021
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7NSU
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![BU of 7nsu by Molmil](/molmil-images/mine/7nsu) | ColicinE9 intact translocation complex | Descriptor: | Colicin-E9, Outer membrane protein F, Tol-Pal system protein TolB, ... | Authors: | Webby, M.N, Kleanthous, C, Lukoyanova, N, Housden, N.G. | Deposit date: | 2021-03-08 | Release date: | 2021-08-11 | Last modified: | 2021-11-17 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Porin threading drives receptor disengagement and establishes active colicin transport through Escherichia coli OmpF. Embo J., 40, 2021
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6EZD
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6GWJ
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![BU of 6gwj by Molmil](/molmil-images/mine/6gwj) | Human OSGEP / LAGE3 / GON7 complex | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, EKC/KEOPS complex subunit GON7, ... | Authors: | Missoury, S, Liger, D, Durand, D, Collinet, B, Tilbeurgh, V.H. | Deposit date: | 2018-06-25 | Release date: | 2019-07-03 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Defects in t 6 A tRNA modification due to GON7 and YRDC mutations lead to Galloway-Mowat syndrome. Nat Commun, 10, 2019
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3N2V
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3N2U
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![BU of 3n2u by Molmil](/molmil-images/mine/3n2u) | Crystal structure of the catalytic domain of human MMP12 complexed with the inhibitor N-hydroxy-2-(4-methoxy-N(2-(3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yloxy)ethyl)phenylsulfonamido)acetamide | Descriptor: | CALCIUM ION, Macrophage metalloelastase, N-hydroxy-2-{[(4-methoxyphenyl)sulfonyl](2-{[(2R,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl]oxy}ethyl)amino}acetamide, ... | Authors: | Calderone, V. | Deposit date: | 2010-05-19 | Release date: | 2010-11-10 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Structure-based approach to nanomolar, water soluble matrix metalloproteinases inhibitors (MMPIs). Eur.J.Med.Chem., 45, 2010
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2E7Z
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![BU of 2e7z by Molmil](/molmil-images/mine/2e7z) | Acetylene Hydratase from Pelobacter acetylenicus | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-AMINO-5,6-DIMERCAPTO-7-METHYL-3,7,8A,9-TETRAHYDRO-8-OXA-1,3,9,10-TETRAAZA-ANTHRACEN-4-ONE GUANOSINE DINUCLEOTIDE, ACETATE ION, ... | Authors: | Einsle, O, Kroneck, P.M.H, Seiffert, G.B, Messerschmidt, A. | Deposit date: | 2007-01-15 | Release date: | 2007-02-27 | Last modified: | 2019-09-04 | Method: | X-RAY DIFFRACTION (1.26 Å) | Cite: | Structure of the non-redox-active tungsten/[4Fe:4S] enzyme acetylene hydratase Proc.Natl.Acad.Sci.Usa, 104, 2007
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6YLI
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6YLD
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![BU of 6yld by Molmil](/molmil-images/mine/6yld) | Crystal structure of Trichoplax adhaerens trBcl-2L2 bound to trBak BH3 | Descriptor: | 1,2-ETHANEDIOL, Bcl-2 homologous antagonist/killer, Bcl-2-like protein 1, ... | Authors: | D Sa, J, Banjara, S, Kvansakul, M. | Deposit date: | 2020-04-07 | Release date: | 2021-03-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Ancient and conserved functional interplay between Bcl-2 family proteins in the mitochondrial pathway of apoptosis. Sci Adv, 6, 2020
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2V5U
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![BU of 2v5u by Molmil](/molmil-images/mine/2v5u) | I92A FLAVODOXIN FROM ANABAENA | Descriptor: | FLAVIN MONONUCLEOTIDE, FLAVODOXIN | Authors: | Martinez-Julvez, M, Herguedas, B, Frago, S, Serrano, A, Molina, R, Hamiaux, C, Schierbeek, B, Medina, M, Hermoso, J.A. | Deposit date: | 2007-07-10 | Release date: | 2007-10-16 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Tuning of the Fmn Binding and Oxido-Reduction Properties by Neighboring Side Chains in Anabaena Flavodoxin. Arch.Biochem.Biophys., 467, 2007
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4XW2
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![BU of 4xw2 by Molmil](/molmil-images/mine/4xw2) | Structural basis for simvastatin competitive antagonism of complement receptor 3 | Descriptor: | Integrin alpha-M, MAGNESIUM ION, Simvastatin acid | Authors: | Bajic, G, Jensen, M.R, Vorup-Jensen, T, Andersen, G.R. | Deposit date: | 2015-01-28 | Release date: | 2016-01-13 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | Structural Basis for Simvastatin Competitive Antagonism of Complement Receptor 3. J.Biol.Chem., 291, 2016
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5O4L
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![BU of 5o4l by Molmil](/molmil-images/mine/5o4l) | Crystal structure of P450 CYP121 in complex with compound 6a. | Descriptor: | 1-[(4-fluorophenyl)methyl]-4-(3-imidazol-1-ylpropyl)piperazin-2-one, Mycocyclosin synthase, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Levy, C.W. | Deposit date: | 2017-05-29 | Release date: | 2018-03-28 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation. J. Med. Chem., 60, 2017
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5O4K
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![BU of 5o4k by Molmil](/molmil-images/mine/5o4k) | Crystal structure of P450 CYP121 in complex with compound 6b. | Descriptor: | 1-[(4-chlorophenyl)methyl]-4-(3-imidazol-1-ylpropyl)piperazin-2-one, Mycocyclosin synthase, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Levy, C.W. | Deposit date: | 2017-05-29 | Release date: | 2018-03-28 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation. J. Med. Chem., 60, 2017
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5O7V
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5O7W
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![BU of 5o7w by Molmil](/molmil-images/mine/5o7w) | Crystal structure of the 4-FLUORO RSL lectin in complex with Lewis x tetrasaccharide | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, Putative fucose-binding lectin protein, ... | Authors: | Varrot, A. | Deposit date: | 2017-06-09 | Release date: | 2018-06-06 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Effect of Noncanonical Amino Acids on Protein-Carbohydrate Interactions: Structure, Dynamics, and Carbohydrate Affinity of a Lectin Engineered with Fluorinated Tryptophan Analogs. ACS Chem. Biol., 13, 2018
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5O7U
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5T4W
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5N5K
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6CKU
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![BU of 6cku by Molmil](/molmil-images/mine/6cku) | Solution structure of the zebrafish granulin AaE | Descriptor: | Granulin-AaE | Authors: | Wang, P, Ni, F. | Deposit date: | 2018-02-28 | Release date: | 2018-06-13 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Structure dissection of zebrafish progranulins identifies a well-folded granulin/epithelin module protein with pro-cell survival activities. Protein Sci., 27, 2018
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5N5J
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![BU of 5n5j by Molmil](/molmil-images/mine/5n5j) | Human MMP12 in complex with 3-(5-(1,2-dithiolan-3-yl)pentanamido)propane-1-sulfonate | Descriptor: | 3-[5-[(3~{S})-1,2-dithiolan-3-yl]pentanoylamino]propane-1-sulfonic acid, ACETOHYDROXAMIC ACID, CALCIUM ION, ... | Authors: | Calderone, V. | Deposit date: | 2017-02-14 | Release date: | 2017-11-01 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Lipoyl-Homotaurine Derivative (ADM_12) Reverts Oxaliplatin-Induced Neuropathy and Reduces Cancer Cells Malignancy by Inhibiting Carbonic Anhydrase IX (CAIX). J. Med. Chem., 60, 2017
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4MVA
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![BU of 4mva by Molmil](/molmil-images/mine/4mva) | 1.43 Angstrom Resolution Crystal Structure of Triosephosphate Isomerase (tpiA) from Escherichia coli in Complex with Acetyl Phosphate. | Descriptor: | 1,2-ETHANEDIOL, ACETYLPHOSPHATE, CHLORIDE ION, ... | Authors: | Minasov, G, Kuhn, M.L, Dubrovska, I, Winsor, J, Shuvalova, L, Grimshaw, S, Kwon, K, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2013-09-23 | Release date: | 2014-04-16 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.43 Å) | Cite: | Structural, kinetic and proteomic characterization of acetyl phosphate-dependent bacterial protein acetylation. Plos One, 9, 2014
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