2L43
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2l43 by Molmil](/molmil-images/mine/2l43) | Structural basis for histone code recognition by BRPF2-PHD1 finger | Descriptor: | Histone H3.3,LINKER,Bromodomain-containing protein 1, ZINC ION | Authors: | Qin, S, Zhang, J, Wu, J, Shi, Y. | Deposit date: | 2010-10-01 | Release date: | 2011-08-31 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Recognition of unmodified histone H3 by the first PHD finger of Bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases MOZ and MORF To be Published
|
|
6IYC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6iyc by Molmil](/molmil-images/mine/6iyc) | Recognition of the Amyloid Precursor Protein by Human gamma-secretase | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Zhou, R, Yang, G, Guo, X, Zhou, Q, Lei, J, Shi, Y. | Deposit date: | 2018-12-14 | Release date: | 2019-01-23 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Recognition of the amyloid precursor protein by human gamma-secretase. Science, 363, 2019
|
|
2LNW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2lnw by Molmil](/molmil-images/mine/2lnw) | Identification and structural basis for a novel interaction between Vav2 and Arap3 | Descriptor: | Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3, Guanine nucleotide exchange factor VAV2 | Authors: | Wu, B, Zhang, J, Wu, J, Shi, Y. | Deposit date: | 2012-01-05 | Release date: | 2012-11-21 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Identification and structural basis for a novel interaction between Vav2 and Arap3. J.Struct.Biol., 180, 2012
|
|
2LKZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2lkz by Molmil](/molmil-images/mine/2lkz) | Solution structure of the second RRM domain of RBM5 | Descriptor: | RNA-binding protein 5 | Authors: | Song, Z, Wu, P, Zhang, J, Wu, J, Shi, Y. | Deposit date: | 2011-10-23 | Release date: | 2012-08-08 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the second RRM domain of RBM5 and its unusual binding characters for different RNA targets Biochemistry, 2012
|
|
2LNX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2lnx by Molmil](/molmil-images/mine/2lnx) | Solution structure of Vav2 SH2 domain | Descriptor: | Guanine nucleotide exchange factor VAV2 | Authors: | Wu, B, Zhang, J, Wu, J, Shi, Y. | Deposit date: | 2012-01-05 | Release date: | 2012-11-21 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Identification and structural basis for a novel interaction between Vav2 and Arap3. J.Struct.Biol., 180, 2012
|
|
2LUY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2luy by Molmil](/molmil-images/mine/2luy) | Solution structure of the tandem zinc finger domain of fission yeast Stc1 | Descriptor: | Meiotic chromosome segregation protein P8B7.28c, ZINC ION | Authors: | He, C, Shi, Y, Bayne, E, Wu, J. | Deposit date: | 2012-06-22 | Release date: | 2013-05-08 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structural analysis of Stc1 provides insights into the coupling of RNAi and chromatin modification. Proc.Natl.Acad.Sci.USA, 110, 2013
|
|
6KZ1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6kz1 by Molmil](/molmil-images/mine/6kz1) | Complex structure of Whirlin and Myosin XVa | Descriptor: | Myosin XVa, Whirlin | Authors: | Lin, L, Wang, M, Shi, Y, Zhu, J, Zhang, R. | Deposit date: | 2019-09-22 | Release date: | 2020-09-23 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.694 Å) | Cite: | Phase separation-mediated condensation of Whirlin-Myo15-Eps8 stereocilia tip complex. Cell Rep, 34, 2021
|
|
2NRF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2nrf by Molmil](/molmil-images/mine/2nrf) | Crystal Structure of GlpG, a Rhomboid family intramembrane protease | Descriptor: | Protein GlpG | Authors: | Wu, Z, Yan, N, Feng, L, Yan, H, Gu, L, Shi, Y. | Deposit date: | 2006-11-02 | Release date: | 2006-11-14 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural analysis of a rhomboid family intramembrane protease reveals a gating mechanism for substrate entry. Nat.Struct.Mol.Biol., 13, 2006
|
|
6ID1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6id1 by Molmil](/molmil-images/mine/6id1) | Cryo-EM structure of a human intron lariat spliceosome after Prp43 loaded (ILS2 complex) at 2.9 angstrom resolution | Descriptor: | 116 kDa U5 small nuclear ribonucleoprotein component, CWF19-like protein 2, Cell division cycle 5-like protein, ... | Authors: | Zhang, X, Zhan, X, Yan, C, Shi, Y. | Deposit date: | 2018-09-07 | Release date: | 2019-03-13 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Structures of the human spliceosomes before and after release of the ligated exon. Cell Res., 29, 2019
|
|
2NWM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2nwm by Molmil](/molmil-images/mine/2nwm) | |
6J6H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6j6h by Molmil](/molmil-images/mine/6j6h) | Cryo-EM structure of the yeast B*-a1 complex at an average resolution of 3.6 angstrom | Descriptor: | ACT1 pre-mRNA, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. | Deposit date: | 2019-01-15 | Release date: | 2019-04-24 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching. Cell, 177, 2019
|
|
6J6N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6j6n by Molmil](/molmil-images/mine/6j6n) | Cryo-EM structure of the yeast B*-b1 complex at an average resolution of 3.86 angstrom | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... | Authors: | Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. | Deposit date: | 2019-01-15 | Release date: | 2019-04-24 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3.86 Å) | Cite: | Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching. Cell, 177, 2019
|
|
6J6Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6j6q by Molmil](/molmil-images/mine/6j6q) | Cryo-EM structure of the yeast B*-b2 complex at an average resolution of 3.7 angstrom | Descriptor: | GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... | Authors: | Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. | Deposit date: | 2019-01-15 | Release date: | 2019-04-24 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching. Cell, 177, 2019
|
|
6JCG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6jcg by Molmil](/molmil-images/mine/6jcg) | Room temperature structure of HIV-1 Integrase catalytic core domain by serial femtosecond crystallography. | Descriptor: | CACODYLATE ION, Integrase | Authors: | Park, J.H, Shi, Y, Han, J, Li, X, Kim, T.H, Yun, J.H. | Deposit date: | 2019-01-28 | Release date: | 2019-07-17 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Non-Cryogenic Structure and Dynamics of HIV-1 Integrase Catalytic Core Domain by X-ray Free-Electron Lasers. Int J Mol Sci, 20, 2019
|
|
6LR4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6lr4 by Molmil](/molmil-images/mine/6lr4) | Molecular basis for inhibition of human gamma-secretase by small molecule | Descriptor: | (2S)-2-hydroxy-3-methyl-N-[(2S)-1-[[(5S)-3-methyl-4-oxo-2,5-dihydro-1H-3-benzazepin-5-yl]amino]-1-oxopropan-2-yl]butanamide, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yang, G, Zhou, R, Guo, X, Lei, J, Shi, Y. | Deposit date: | 2020-01-15 | Release date: | 2021-01-27 | Last modified: | 2021-02-03 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural basis of gamma-secretase inhibition and modulation by small molecule drugs. Cell, 184, 2021
|
|
6LQG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6lqg by Molmil](/molmil-images/mine/6lqg) | Human gamma-secretase in complex with small molecule Avagacestat | Descriptor: | (2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoranyl-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-tris(fluoranyl)pentanamide, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Yang, G, Zhou, R, Guo, X, Lei, J, Shi, Y. | Deposit date: | 2020-01-13 | Release date: | 2021-01-27 | Last modified: | 2021-02-03 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural basis of gamma-secretase inhibition and modulation by small molecule drugs. Cell, 184, 2021
|
|
2OPY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2opy by Molmil](/molmil-images/mine/2opy) | Smac mimic bound to BIR3-XIAP | Descriptor: | 1-({2-[(1S)-1-AMINOETHYL]-1,3-OXAZOL-4-YL}CARBONYL)-L-PROLYL-L-TRYPTOPHAN, Baculoviral IAP repeat-containing protein 4, ZINC ION | Authors: | Wist, A.D, Lu, G, Riedl, S.J, Shi, Y, McLendon, G.L. | Deposit date: | 2007-01-30 | Release date: | 2007-02-20 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structure-activity based study of the Smac-binding pocket within the BIR3 domain of XIAP. Bioorg.Med.Chem., 15, 2007
|
|
2P1L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2p1l by Molmil](/molmil-images/mine/2p1l) | |
6KMS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6kms by Molmil](/molmil-images/mine/6kms) | Crystal structure of human N6amt1-Trm112 in complex with SAM (space group I422) | Descriptor: | Methyltransferase N6AMT1, Multifunctional methyltransferase subunit TRM112-like protein, S-ADENOSYLMETHIONINE | Authors: | Li, W.J, Shi, Y, Zhang, T.L, Ye, J, Ding, J.P. | Deposit date: | 2019-08-01 | Release date: | 2019-09-18 | Last modified: | 2019-11-06 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural insight into human N6amt1-Trm112 complex functioning as a protein methyltransferase. Cell Discov, 5, 2019
|
|
6KMR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6kmr by Molmil](/molmil-images/mine/6kmr) | Crystal structure of human N6amt1-Trm112 in complex with SAM (space group P6122) | Descriptor: | 1,2-ETHANEDIOL, Methyltransferase N6AMT1, Multifunctional methyltransferase subunit TRM112-like protein, ... | Authors: | Li, W.J, Shi, Y, Zhang, T.L, Ye, J, Ding, J.P. | Deposit date: | 2019-08-01 | Release date: | 2019-09-18 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural insight into human N6amt1-Trm112 complex functioning as a protein methyltransferase. Cell Discov, 5, 2019
|
|
6J6G
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6j6g by Molmil](/molmil-images/mine/6j6g) | Cryo-EM structure of the yeast B*-a2 complex at an average resolution of 3.2 angstrom | Descriptor: | ACT1 pre-mRNA, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Wan, R, Bai, R, Yan, C, Lei, J, Shi, Y. | Deposit date: | 2019-01-15 | Release date: | 2019-04-24 | Last modified: | 2020-10-14 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching. Cell, 177, 2019
|
|
2P5B
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2p5b by Molmil](/molmil-images/mine/2p5b) | The complex structure of JMJD2A and trimethylated H3K36 peptide | Descriptor: | FE (II) ION, Histone H3, JmjC domain-containing histone demethylation protein 3A, ... | Authors: | Zhang, G, Chen, Z, Zang, J, Hong, X, Shi, Y. | Deposit date: | 2007-03-14 | Release date: | 2007-06-12 | Last modified: | 2013-11-27 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Structural basis of the recognition of a methylated histone tail by JMJD2A. Proc.Natl.Acad.Sci.USA, 104, 2007
|
|
2PPH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2pph by Molmil](/molmil-images/mine/2pph) | solution structure of human MEKK3 PB1 domain | Descriptor: | Mitogen-activated protein kinase kinase kinase 3 | Authors: | Hu, Q, Zhang, J, Wu, J, Shi, Y. | Deposit date: | 2007-04-30 | Release date: | 2007-05-22 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Insight into the Binding Properties of MEKK3 PB1 to MEK5 PB1 from Its Solution Structure. Biochemistry, 46, 2007
|
|
2PKU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2pku by Molmil](/molmil-images/mine/2pku) | Solution structure of PICK1 PDZ in complex with the carboxyl tail peptide of GluR2 | Descriptor: | PRKCA-binding protein, peptide (GLU)(SER)(VAL)(LYS)(ILE) | Authors: | Pan, L, Wu, H, Shen, C, Shi, Y, Xia, J, Zhang, M. | Deposit date: | 2007-04-18 | Release date: | 2007-11-20 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | Clustering and synaptic targeting of PICK1 requires direct interaction between the PDZ domain and lipid membranes Embo J., 26, 2007
|
|
2Q0O
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2q0o by Molmil](/molmil-images/mine/2q0o) | Crystal structure of an anti-activation complex in bacterial quorum sensing | Descriptor: | 3-OXO-OCTANOIC ACID (2-OXO-TETRAHYDRO-FURAN-3-YL)-AMIDE, Probable transcriptional activator protein traR, Probable transcriptional repressor traM | Authors: | Chen, G, Jeffrey, P.D, Fuqua, C, Shi, Y, Chen, L. | Deposit date: | 2007-05-22 | Release date: | 2007-09-25 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for antiactivation in bacterial quorum sensing. Proc.Natl.Acad.Sci.Usa, 104, 2007
|
|