2OPY

Smac mimic bound to BIR3-XIAP

Summary for 2OPY

• Entry DOI: 10.2210/pdb2opy/pdb
• Related: 1G3F 1G73 2I3H 2OPZ
• Descriptor: Baculoviral IAP repeat-containing protein 4, ZINC ION, 1-({2-[(1S)-1-AMINOETHYL]-1,3-OXAZOL-4-YL}CARBONYL)-L-PROLYL-L-TRYPTOPHAN, ... (4 entities in total)
• Functional Keywords: peptide mimic, bir3, apoptosis activator
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P98170
• Total number of polymer chains: 1
• Total formula weight: 12777.61

Authors

Wist, A.D.,Lu, G.,Riedl, S.J.,Shi, Y.,McLendon, G.L. (deposition date: 2007-01-30, release date: 2007-02-20, Last modification date: 2023-12-27)

• Primary citation: Wist, A.D.,Gu, L.,Riedl, S.J.,Shi, Y.,McLendon, G.L.; Structure-activity based study of the Smac-binding pocket within the BIR3 domain of XIAP.; Bioorg.Med.Chem., 15:2935-2943, 2007; PubMed: 17336535; DOI: 10.1016/j.bmc.2007.02.010

Experimental method

X-RAY DIFFRACTION (2.8 Å)