4IOI
 
 | | Meditope-enabled trastuzumab in complex with CQFDLSTRRLKC | | Descriptor: | Immunoglobulin G-binding protein A, Protein L, Trastuzumab heavy chain, ... | | Authors: | Bzymek, K.P, Zer, C, Avery, K.N, Williams, J.C. | | Deposit date: | 2013-01-07 | | Release date: | 2013-10-09 | | Last modified: | 2013-11-06 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Identification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4GW1
 | | cQFD Meditope | | Descriptor: | Fab heavy chain, Fab light chain, PHOSPHATE ION, ... | | Authors: | Donaldson, J.M, Zer, C, Avery, K.N, Bzymek, K.P, Horne, D.A, Williams, J.C. | | Deposit date: | 2012-08-31 | | Release date: | 2013-10-09 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.24 Å) | | Cite: | Identification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4GW5
 | | cQYN meditope - Cetuximab Fab | | Descriptor: | Fab Heavy Chain, Fab Light Chain, PHOSPHATE ION, ... | | Authors: | Donaldson, J.M, Zer, C, Avery, K.N, Bzymek, K.P, Horne, D.A, Williams, J.C. | | Deposit date: | 2012-08-31 | | Release date: | 2013-10-09 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Identification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4HJG
 | | Meditope-enabled trastuzumab | | Descriptor: | Immunoglobulin G-binding protein A, Protein L fragment, Trastuzumab heavy chain, ... | | Authors: | Donaldson, J.M, Zer, C, Avery, K.N, Bzymek, K.P, Horne, D.A, Williams, J.C. | | Deposit date: | 2012-10-12 | | Release date: | 2013-10-09 | | Last modified: | 2013-11-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Identification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4HKZ
 | | Trastuzumab Fab complexed with Protein L and Protein A fragments | | Descriptor: | CHLORIDE ION, Immunoglobulin G-binding protein A, Protein L fragment, ... | | Authors: | Avery, K.N, Zer, C, Bzymek, K.P, Williams, J.C. | | Deposit date: | 2012-10-15 | | Release date: | 2013-10-09 | | Last modified: | 2017-11-15 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Identification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies.
Proc.Natl.Acad.Sci.USA, 110, 2013
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5EUK
 | | Cetuximab Fab in complex with F3H meditope variant | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cetuximab Fab heavy chain, Cetuximab Fab light chain, ... | | Authors: | Bzymek, K.P, Williams, J.C. | | Deposit date: | 2015-11-18 | | Release date: | 2016-10-26 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Natural and non-natural amino-acid side-chain substitutions: affinity and diffraction studies of meditope-Fab complexes.
Acta Crystallogr F Struct Biol Commun, 72, 2016
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5ESQ
 | | Cetuximab Fab in complex with cyclic beta-alanine-linked meditope | | Descriptor: | Cetuximab Fab heavy chain, Cetuximab Fab light chain, Cyclic beta-alanine-linked meditope, ... | | Authors: | Bzymek, K.P, Williams, J.C. | | Deposit date: | 2015-11-16 | | Release date: | 2016-06-15 | | Last modified: | 2017-12-13 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Cyclization strategies of meditopes: affinity and diffraction studies of meditope-Fab complexes.
Acta Crystallogr F Struct Biol Commun, 72, 2016
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5ETU
 | | Cetuximab Fab in complex with L5E meditope variant | | Descriptor: | Cetuximab Fab heavy chain, Cetuximab Fab light chain, L5E meditope variant, ... | | Authors: | Bzymek, K.P, Williams, J.C. | | Deposit date: | 2015-11-18 | | Release date: | 2016-10-26 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.53 Å) | | Cite: | Natural and non-natural amino-acid side-chain substitutions: affinity and diffraction studies of meditope-Fab complexes.
Acta Crystallogr F Struct Biol Commun, 72, 2016
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3GD1
 | | Structure of an Arrestin/Clathrin complex reveals a novel clathrin binding domain that modulates receptor trafficking | | Descriptor: | Beta-arrestin-1, Clathrin heavy chain 1, clathrin | | Authors: | Kang, D.S, Kern, R.C, Puthenveedu, M.A, von Zastrow, M, Williams, J.C, Benovic, J.L. | | Deposit date: | 2009-02-23 | | Release date: | 2009-08-25 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Structure of an arrestin2-clathrin complex reveals a novel clathrin binding domain that modulates receptor trafficking
J.Biol.Chem., 284, 2009
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5T1K
 | | Cetuximab Fab in complex with CQFDA(Ph)2STRRLKC | | Descriptor: | CETUXIMAB FAB HEAVY CHAIN, CETUXIMAB FAB LIGHT CHAIN, CQFDA(PH)2STRRLKC PEPTIDE, ... | | Authors: | Bzymek, K.P, Williams, J.C. | | Deposit date: | 2016-08-19 | | Release date: | 2016-10-26 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.48 Å) | | Cite: | Natural and non-natural amino-acid side-chain substitutions: affinity and diffraction studies of meditope-Fab complexes.
Acta Crystallogr F Struct Biol Commun, 72, 2016
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5T1M
 | | Cetuximab Fab in complex with CQYDLSTRRLKC | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CETUXIMAB FAB HEAVY CHAIN, CETUXIMAB FAB LIGHT CHAIN, ... | | Authors: | Bzymek, K.P, Williams, J.C. | | Deposit date: | 2016-08-19 | | Release date: | 2016-10-26 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.53 Å) | | Cite: | Natural and non-natural amino-acid side-chain substitutions: affinity and diffraction studies of meditope-Fab complexes.
Acta Crystallogr F Struct Biol Commun, 72, 2016
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5T1L
 | | Cetuximab Fab in complex with CQA(Ph)2DLSTRRLKC peptide | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CETUXIMAB FAB HEAVY CHAIN, CETUXIMAB FAB LIGHT CHAIN, ... | | Authors: | Bzymek, K.P, Williams, J.C. | | Deposit date: | 2016-08-19 | | Release date: | 2016-10-26 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.48 Å) | | Cite: | Natural and non-natural amino-acid side-chain substitutions: affinity and diffraction studies of meditope-Fab complexes.
Acta Crystallogr F Struct Biol Commun, 72, 2016
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5TH2
 | | Cetuximab Fab in complex with L5Q meditope variant | | Descriptor: | L5Q meditope, PHOSPHATE ION, cetuximab Fab, ... | | Authors: | Bzymek, K.P, Williams, J.C. | | Deposit date: | 2016-09-28 | | Release date: | 2016-10-26 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Natural and non-natural amino-acid side-chain substitutions: affinity and diffraction studies of meditope-Fab complexes.
Acta Crystallogr F Struct Biol Commun, 72, 2016
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5U5F
 | | MEDITOPE ENABLED TRASTUZUMAB I83E VARIANT IN COMPLEX WITH (Ac) CQFDA(PH)2STRRLRCGGSK | | Descriptor: | 5-DIPHENYL LONG MEDITOPE, Immunoglobulin G binding protein A, MEMAB TRASTUZUMAB FAB HEAVY CHAIN, ... | | Authors: | Bzymek, K.P, Avery, K.N, Zer, C, Williams, J.C. | | Deposit date: | 2016-12-06 | | Release date: | 2018-03-14 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.81 Å) | | Cite: | Meditope Enabled Trastuzumab I83E Variant In Complex With (Ac)Cqfda(Ph)2Strrlrcggsk
To Be Published
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5U3D
 | | STRUCTURE OF MEDITOPE ENABLED TRASTUZUMAB I83E VARIANT | | Descriptor: | Immunoglobulin G binding protein A, MEMAB TRASTUZUMAB FAB HEAVY CHAIN, MEMAB TRASTUZUMAB FAB LIGHT CHAIN I83E, ... | | Authors: | Bzymek, K.P, Avery, K.N, Zer, C, Williams, J.C. | | Deposit date: | 2016-12-01 | | Release date: | 2018-03-14 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Meditope Enabled Trastuzumab I83E Variant
To Be Published
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7JKM
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5C39
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1QDS
 | | SUPERSTABLE E65Q MUTANT OF LEISHMANIA MEXICANA TRIOSEPHOSPHATE ISOMERASE (TIM) | | Descriptor: | 2-PHOSPHOGLYCOLIC ACID, TRIOSEPHOSPHATE ISOMERASE | | Authors: | Lambeir, A.M, Backmann, J, Ruiz-Sanz, J, Filimonov, V, Nielsen, J.E, Vriend, G, Kursula, I, Norledge, B.V, Wierenga, R.K. | | Deposit date: | 1999-07-10 | | Release date: | 2000-12-13 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The ionization of a buried glutamic acid is thermodynamically linked to the stability of Leishmania mexicana triose phosphate isomerase.
Eur.J.Biochem., 267, 2000
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1EAS
 | | NONPEPTIDIC INHIBITORS OF HUMAN LEUKOCYTE ELASTASE. 3. DESIGN, SYNTHESIS, X-RAY CRYSTALLOGRAPHIC ANALYSIS, AND STRUCTURE-ACTIVITY RELATIONSHIPS FOR A SERIES OF ORALLY ACTIVE 3-AMINO-6-PHENYLPYRIDIN-2-ONE TRIFLUOROMETHYL KETONES | | Descriptor: | 3-[[(METHYLAMINO)SULFONYL]AMINO]-2-OXO-6-PHENYL-N-[3,3,3-TRIFLUORO-1-(1-METHYLETHYL)-2-OXOPHENYL]-1(2H)-PYRIDINE ACETAMIDE, PORCINE PANCREATIC ELASTASE, SODIUM ION, ... | | Authors: | Ceccarelli, C. | | Deposit date: | 1994-11-22 | | Release date: | 1995-02-07 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Nonpeptidic inhibitors of human leukocyte elastase. 3. Design, synthesis, X-ray crystallographic analysis, and structure-activity relationships for a series of orally active 3-amino-6-phenylpyridin-2-one trifluoromethyl ketones.
J.Med.Chem., 37, 1994
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1EAU
 | | NONPEPTIDIC INHIBITORS OF HUMAN LEUKOCYTE ELASTASE. 6. DESIGN OF A POTENT, INTRATRACHEALLY ACTIVE, PYRIDONE-BASED TRIFLUOROMETHYL KETONE | | Descriptor: | 2-[5-AMINO-6-OXO-2-(2-THIENYL)-1,6-DIHYDROPYRIMIDIN-1-YL)-N-[3,3-DIFLUORO -1-ISOPROPYL-2-OXO-3-(N-(2-MORPHOLINO ETHYL)CARBAMOYL]PROPYL]ACETAMIDE, PORCINE PANCREATIC ELASTASE, SODIUM ION, ... | | Authors: | Ceccarelli, C. | | Deposit date: | 1994-11-22 | | Release date: | 1995-02-07 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Nonpeptidic inhibitors of human leukocyte elastase. 6. Design of a potent, intratracheally active, pyridone-based trifluoromethyl ketone.
J.Med.Chem., 38, 1995
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1EAT
 | | NONPEPTIDIC INHIBITORS OF HUMAN LEUKOCYTE ELASTASE. 5. DESIGN, SYNTHESIS, AND X-RAY CRYSTALLOGRAPHY OF A SERIES OF ORALLY ACTIVE 5-AMINO-PYRIMIDIN-6-ONE-CONTAINING TRIFLUOROMETHYLKETONES | | Descriptor: | 2-[5-METHANESULFONYLAMINO-2-(4-AMINOPHENYL)-6-OXO-1,6-DIHYDRO-1-PYRIMIDINYL]-N-(3,3,3-TRIFLUORO-1-ISOPROPYL-2-OXOPROPYL)ACETAMIDE, PORCINE PANCREATIC ELASTASE, SODIUM ION, ... | | Authors: | Ceccarelli, C. | | Deposit date: | 1994-11-22 | | Release date: | 1995-02-07 | | Last modified: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Nonpeptidic inhibitors of human leukocyte elastase. 5. Design, synthesis, and X-ray crystallography of a series of orally active 5-aminopyrimidin-6-one-containing trifluoromethyl ketones.
J.Med.Chem., 38, 1995
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2MPX
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1Z9K
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7UZ9
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7UZ8
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