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4IOI

Meditope-enabled trastuzumab in complex with CQFDLSTRRLKC

Summary for 4IOI
Entry DOI10.2210/pdb4ioi/pdb
Related4HJG
DescriptorTrastuzumab light chain, Trastuzumab heavy chain, Immunoglobulin G-binding protein A, ... (6 entities in total)
Functional Keywordsmonoclonal antibody, immune system, cancer immunotherapy
Biological sourceHomo sapiens
More
Cellular locationSecreted, cell wall; Peptidoglycan-anchor (Potential): P0A015
Total number of polymer chains5
Total formula weight61868.75
Authors
Bzymek, K.P.,Zer, C.,Avery, K.N.,Williams, J.C. (deposition date: 2013-01-07, release date: 2013-10-09, Last modification date: 2013-11-06)
Primary citationDonaldson, J.M.,Zer, C.,Avery, K.N.,Bzymek, K.P.,Horne, D.A.,Williams, J.C.
Identification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies.
Proc.Natl.Acad.Sci.USA, 110:17456-17461, 2013
Cited by
PubMed: 24101516
DOI: 10.1073/pnas.1307309110
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.95 Å)
Structure validation

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