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7QE3
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BU of 7qe3 by Molmil
Se-M variant of B-trefoil lectin from Salpingoeca rosetta in complex with GalNAc
Descriptor: (2S)-hexane-1,2,6-triol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-galactopyranose, ...
Authors:Notova, S, Varrot, A.
Deposit date:2021-12-01
Release date:2022-09-14
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The choanoflagellate pore-forming lectin SaroL-1 punches holes in cancer cells by targeting the tumor-related glycosphingolipid Gb3.
Commun Biol, 5, 2022
7QE4
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BU of 7qe4 by Molmil
B-trefoil lectin from Salpingoeca rosetta in complex with GalNAc
Descriptor: 2-acetamido-2-deoxy-alpha-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-galactopyranose, CHLORIDE ION, ...
Authors:Notova, S, Varrot, A.
Deposit date:2021-12-01
Release date:2022-09-14
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:The choanoflagellate pore-forming lectin SaroL-1 punches holes in cancer cells by targeting the tumor-related glycosphingolipid Gb3.
Commun Biol, 5, 2022
7R55
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BU of 7r55 by Molmil
B-trefoil lectin from Salpingoeca rosetta in complex with Gb3
Descriptor: 1,2-ETHANEDIOL, Sarol-1, alpha-D-galactopyranose-(1-4)-beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose
Authors:Notova, S, Varrot, A.
Deposit date:2022-02-10
Release date:2022-09-14
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:The choanoflagellate pore-forming lectin SaroL-1 punches holes in cancer cells by targeting the tumor-related glycosphingolipid Gb3.
Commun Biol, 5, 2022
5A6Y
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BU of 5a6y by Molmil
Structure of the LecB lectin from Pseudomonas aeruginosa strain PA14 in complex with mannose-alpha1,3mannoside
Descriptor: CALCIUM ION, FUCOSE-BINDING LECTIN PA-IIL, GLYCEROL, ...
Authors:Sommer, R, Wagner, S, Varrot, A, Khaledi, A, Haussler, S, Imberty, A, Titz, A.
Deposit date:2015-07-02
Release date:2016-05-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The virulence factor LecB varies in clinical isolates: consequences for ligand binding and drug discovery.
Chem Sci, 7, 2016
5A70
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BU of 5a70 by Molmil
Structure of the LecB lectin from Pseudomonas aeruginosa strain PA14 in complex with lewis x tetrasaccharide
Descriptor: CALCIUM ION, LECB, SULFATE ION, ...
Authors:Sommer, R, Wagner, S, Varrot, A, Khaledi, A, Haussler, S, Imberty, A, Titz, A.
Deposit date:2015-07-02
Release date:2016-07-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Induction of rare conformation of oligosaccharide by binding to calcium-dependent bacterial lectin: X-ray crystallography and modelling study.
Eur.J.Med.Chem., 177, 2019
4UOU
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BU of 4uou by Molmil
Crystal Structure of Fucose binding lectin from Aspergillus Fumigatus (AFL) - apo-form
Descriptor: DI(HYDROXYETHYL)ETHER, FUCOSE-SPECIFIC LECTIN FLEA
Authors:Houser, J, Komarek, J, Cioci, G, Varrot, A, Imberty, A, Wimmerova, M.
Deposit date:2014-06-10
Release date:2015-03-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Insights Into Aspergillus Fumigatus Lectin Specificity: Afl Binding Sites are Functionally Non-Equivalent.
Acta Crystallogr.,Sect.D, 71, 2015
8QK1
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BU of 8qk1 by Molmil
Crystal structure of Trichuris suis beta-N-acetyl-D-hexosaminidase - HEX-2 in apo form
Descriptor: ZINC ION, beta-N-acetylhexosaminidase
Authors:Dutkiewicz, Z, Varrot, A.
Deposit date:2023-09-14
Release date:2024-06-26
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Nematode hexosaminidases, a new biochemical tool for glycan analysis
To be published
8AIJ
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BU of 8aij by Molmil
STRUCTURE OF THE LECB LECTIN FROM PSEUDOMONAS AERUGINOSA STRAIN PAO1 IN COMPLEX WITH N-(alpha-L-Fucopyranosyl)benzamide (6)
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, Fucose-binding lectin PA-IIL, ...
Authors:Meiers, J, Mala, P, Varrot, A, Siebs, E, Imberty, A, Titz, A.
Deposit date:2022-07-26
Release date:2022-11-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Discovery of N -beta-l-Fucosyl Amides as High-Affinity Ligands for the Pseudomonas aeruginosa Lectin LecB.
J.Med.Chem., 65, 2022
8AIY
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BU of 8aiy by Molmil
STRUCTURE OF THE LECB LECTIN FROM PSEUDOMONAS AERUGINOSA STRAIN PAO1 IN COMPLEX WITH N-(beta-L-Fucopyranosyl)-biphenyl-3-carboxamide (4i)
Descriptor: CALCIUM ION, Fucose-binding lectin PA-IIL, N-(beta-L-Fucopyranosyl)-biphenyl-3-carboxamide, ...
Authors:Meiers, J, Mala, P, Varrot, A, Siebs, E, Imberty, A, Titz, A.
Deposit date:2022-07-27
Release date:2022-11-02
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Discovery of N -beta-l-Fucosyl Amides as High-Affinity Ligands for the Pseudomonas aeruginosa Lectin LecB.
J.Med.Chem., 65, 2022
6GXR
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BU of 6gxr by Molmil
Crystal structure of BP39L lectin from Burkholderia pseudomallei at 1.7 A resolution
Descriptor: BP39L lectin, SULFATE ION
Authors:Sykorova, P, Novotna, J, Demo, G, Pompidor, G, Dubska, E, Komarek, J, Fujdiarova, E, Haronikova, L, Varrot, A, Imberty, A, Shilova, N, Bovin, N, Pokorna, M, Wimmerova, M.
Deposit date:2018-06-27
Release date:2019-12-04
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Characterization of novel lectins from Burkholderia pseudomallei and Chromobacterium violaceum with seven-bladed beta-propeller fold.
Int.J.Biol.Macromol., 152, 2020
4USO
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BU of 4uso by Molmil
X-ray structure of the CCL2 lectin in complex with sialyl lewis X
Descriptor: CCL2 LECTIN, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)]2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Bleuler-Martinez, S, Varrot, A, Schubert, M, Stutz, M, Sieber, R, Hengartner, M, Aebi, M, Kunzler, M.
Deposit date:2014-07-11
Release date:2015-07-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Dimerization of the fungal defense lectin CCL2 is essential for its toxicity against nematodes.
Glycobiology, 27, 2017
4USP
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BU of 4usp by Molmil
X-ray structure of the dimeric CCL2 lectin in native form
Descriptor: CCL2 LECTIN, CHLORIDE ION, PHOSPHATE ION
Authors:Bleuler-Martinez, S, Varrot, A, Schubert, M, Stutz, M, Sieber, R, Hengartner, M, Aebi, M, Kunzler, M.
Deposit date:2014-07-11
Release date:2015-07-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Dimerization of the fungal defense lectin CCL2 is essential for its toxicity against nematodes.
Glycobiology, 27, 2017
6GXS
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BU of 6gxs by Molmil
Crystal structure of CV39L lectin from Chromobacterium violaceum at 1.8 A resolution
Descriptor: 1,2-ETHANEDIOL, CV39L lectin, DI(HYDROXYETHYL)ETHER, ...
Authors:Sykorova, P, Novotna, J, Demo, G, Pompidor, G, Dubska, E, Komarek, J, Fujdiarova, E, Haronikova, L, Varrot, A, Imberty, A, Shilova, N, Bovin, N, Pokorna, M, Wimmerova, M.
Deposit date:2018-06-27
Release date:2019-12-04
Last modified:2024-05-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Characterization of novel lectins from Burkholderia pseudomallei and Chromobacterium violaceum with seven-bladed beta-propeller fold.
Int.J.Biol.Macromol., 152, 2020
1BVO
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BU of 1bvo by Molmil
DORSAL HOMOLOGUE GAMBIF1 BOUND TO DNA
Descriptor: DNA DUPLEX, TRANSCRIPTION FACTOR GAMBIF1
Authors:Cramer, P, Varrot, A, Barillas-Mury, C, Kafatos, F.C, Mueller, C.W.
Deposit date:1998-09-16
Release date:1999-07-12
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of the specificity domain of the Dorsal homologue Gambif1 bound to DNA.
Structure Fold.Des., 7, 1999
8R8A
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BU of 8r8a by Molmil
Structure of the N-terminal domain of CMA in complex with N-acetyllactosamine
Descriptor: CADMIUM ION, Nigrin b-like, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose
Authors:Lundstrom, J, Varrot, A.
Deposit date:2023-11-28
Release date:2023-12-27
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.317 Å)
Cite:Elucidating the glycan-binding specificity and structure of Cucumis melo agglutinin, a new R-type lectin.
Beilstein J Org Chem, 20, 2024
7OLW
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BU of 7olw by Molmil
Structure of the N-terminal domain of BC2L-C lectin (1-131) in complex with a synthetic beta-N-fucoside ligand
Descriptor: 5-(3-aminophenyl)furan-2-carboxamido-(beta-L-fucopyranose), Lectin
Authors:Bermeo, R, Varrot, A.
Deposit date:2021-05-20
Release date:2022-06-01
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.32 Å)
Cite:Targeting a Multidrug-Resistant Pathogen: First Generation Antagonists of Burkholderia cenocepacia 's BC2L-C Lectin.
Acs Chem.Biol., 17, 2022
7OLU
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BU of 7olu by Molmil
Structure of the N-terminal domain of BC2L-C lectin (1-131) in complex with a synthetic beta-C-fucoside ligand
Descriptor: (2-(4-(beta-L-fucopyranosylethynyl)phenyl)-2-methylpropan-1-amine, Lectin
Authors:Bermeo, R, Varrot, A.
Deposit date:2021-05-20
Release date:2022-06-01
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.793 Å)
Cite:Targeting a Multidrug-Resistant Pathogen: First Generation Antagonists of Burkholderia cenocepacia 's BC2L-C Lectin.
Acs Chem.Biol., 17, 2022
6TT9
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BU of 6tt9 by Molmil
rTBL Recombinant Lectin From Tepary Bean
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, HEXANE, ...
Authors:Martinez Alarcon, D, Varrot, A.
Deposit date:2019-12-26
Release date:2020-05-13
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Recombinant Lectin from Tepary Bean (Phaseolus acutifolius) with Specific Recognition for Cancer-Associated Glycans: Production, Structural Characterization, and Target Identification.
Biomolecules, 10, 2020
6EKE
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BU of 6eke by Molmil
crystal structure of a Pholiota squarrosa lectin unliganded
Descriptor: 1,4-BUTANEDIOL, ACETATE ION, ZINC ION, ...
Authors:Cabanettes, A, Varrot, A.
Deposit date:2017-09-26
Release date:2018-07-11
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Recognition of Complex Core-Fucosylated N-Glycans by a Mini Lectin.
Angew. Chem. Int. Ed. Engl., 57, 2018
6FX2
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BU of 6fx2 by Molmil
crystal structure of Pholiota squarrosa lectin in complex with a decasaccharide
Descriptor: beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]1-azido-beta-N-acetyl-D-glucosamine, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]1-azido-beta-N-acetyl-D-glucosamine, lectin
Authors:Cabanettes, A, Varrot, A.
Deposit date:2018-03-08
Release date:2018-07-11
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Recognition of Complex Core-Fucosylated N-Glycans by a Mini Lectin.
Angew. Chem. Int. Ed. Engl., 57, 2018
6FX1
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BU of 6fx1 by Molmil
Crystal structure of Pholiota squarrosa lectin in complex with an octasaccharide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]1-azido-beta-N-acetyl-D-glucosamine, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]1-azido-beta-N-acetyl-D-glucosamine, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]1-azido-beta-N-acetyl-D-glucosamine, ...
Authors:Cabanettes, A, Varrot, A.
Deposit date:2018-03-08
Release date:2018-07-11
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Recognition of Complex Core-Fucosylated N-Glycans by a Mini Lectin.
Angew. Chem. Int. Ed. Engl., 57, 2018
6FX3
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BU of 6fx3 by Molmil
crystal structure of Pholiota squarrosa lectin in complex with a dodecasaccharide
Descriptor: N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]1-azido-beta-N-acetyl-D-glucosamine, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]1-azido-beta-N-acetyl-D-glucosamine, lectin
Authors:Cabanettes, A, Varrot, A.
Deposit date:2018-03-08
Release date:2018-07-11
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Recognition of Complex Core-Fucosylated N-Glycans by a Mini Lectin.
Angew. Chem. Int. Ed. Engl., 57, 2018
5FSB
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BU of 5fsb by Molmil
Structure of tectonin 2 from laccaria bicolor in complex with 2-o-methyl-methyl-seleno-beta-l-fucopyranoside
Descriptor: BORIC ACID, MAGNESIUM ION, SULFATE ION, ...
Authors:Sommer, R, Bleuer, S, Titz, A, Kunzler, M, Varrot, A.
Deposit date:2016-01-04
Release date:2017-03-29
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal Structures of Fungal Tectonin in Complex with O-Methylated Glycans Suggest Key Role in Innate Immune Defense.
Structure, 26, 2018
5FSC
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BU of 5fsc by Molmil
Structure of tectonin 2 from Laccaria bicolor in complex with allyl- alpha_4-methyl-mannoside
Descriptor: MAGNESIUM ION, TECTONIN 2, prop-2-en-1-yl 4-O-methyl-alpha-D-mannopyranoside
Authors:Sommer, R, Bleuer, S, Titz, A, Kunzler, M, Varrot, A.
Deposit date:2016-01-04
Release date:2017-03-29
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structures of Fungal Tectonin in Complex with O-Methylated Glycans Suggest Key Role in Innate Immune Defense.
Structure, 26, 2018
5FRE
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BU of 5fre by Molmil
Characterization of a novel CBM from Clostridium perfringens
Descriptor: 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, ACETATE ION, CALCIUM ION, ...
Authors:Ribeiro, J, Pau, W, Pifferi, C, Renaudet, O, Varrot, A, Mahal, L.K, Imberty, A.
Deposit date:2015-12-17
Release date:2016-07-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Characterization of a High-Affinity Sialic Acid-Specific Cbm40 from Clostridium Perfringens and Engineering of a Divalent Form.
Biochem.J., 473, 2016

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數據於2024-10-16公開中

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