1L6Y
 
 | | Crystal Structure of Porphobilinogen Synthase Complexed with the Inhibitor 4-Oxosebacic Acid | | Descriptor: | 4-OXODECANEDIOIC ACID, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Jaffe, E.K, Kervinen, J, Martins, J, Stauffer, F, Neier, R, Wlodawer, A, Zdanov, A. | | Deposit date: | 2002-03-14 | | Release date: | 2002-04-17 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Species-Specific Inhibition of Porphobilinogen Synthase by 4-Oxosebacic Acid
J.Biol.Chem., 277, 2002
|
|
1UNC
 | | Solution structure of the human villin C-terminal headpiece subdomain | | Descriptor: | VILLIN 1 | | Authors: | Vermeulen, W, Van Troys, M, Vanhaesebrouck, P, Verschueren, M, Fant, F, Ampe, C, Martins, J, Borremans, F. | | Deposit date: | 2003-09-09 | | Release date: | 2004-07-15 | | Last modified: | 2011-07-13 | | Method: | SOLUTION NMR | | Cite: | Solution Structures of the C-Terminal Headpiece Subdomains of Human Villin and Advillin, Evaluation of Headpiece F-Actin-Binding Requirements
Protein Sci., 13, 2004
|
|
1UND
 | | Solution structure of the human advillin C-terminal headpiece subdomain | | Descriptor: | ADVILLIN | | Authors: | Vermeulen, W, Van Troys, M, Vanhaesebrouck, P, Verschueren, M, Fant, F, Ampe, C, Martins, J, Borremans, F. | | Deposit date: | 2003-09-09 | | Release date: | 2004-07-15 | | Last modified: | 2024-10-16 | | Method: | SOLUTION NMR | | Cite: | Solution Structures of the C-Terminal Headpiece Subdomains of Human Villin and Advillin, Evaluation of Headpiece F-Actin-Binding Requirements
Protein Sci., 13, 2004
|
|
6ZK7
 | | Crystal Structure of human PYROXD1/FAD complex | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Pyridine nucleotide-disulfide oxidoreductase domain-containing protein 1 | | Authors: | Meinhart, A, Asanovic, I, Martinez, J, Clausen, T. | | Deposit date: | 2020-06-30 | | Release date: | 2021-05-12 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | The oxidoreductase PYROXD1 uses NAD(P) + as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response.
Mol.Cell, 81, 2021
|
|
3KEP
 | | Crystal structure of the autoproteolytic domain from the nuclear pore complex component NUP145 from Saccharomyces cerevisiae | | Descriptor: | 1,2-ETHANEDIOL, Nucleoporin NUP145 | | Authors: | Sampathkumar, P, Ozyurt, S.A, Do, J, Bain, K, Dickey, M, Gheyi, T, Sali, A, Kim, S.J, Phillips, J, Pieper, U, Fernandez-Martinez, J, Franke, J.D, Atwell, S, Thompson, D.A, Emtage, J.S, Wasserman, S, Rout, M, Sauder, J.M, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | | Deposit date: | 2009-10-26 | | Release date: | 2009-12-22 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Structures of the autoproteolytic domain from the Saccharomyces cerevisiae nuclear pore complex component, Nup145.
Proteins, 78, 2010
|
|
5LPY
 | |
5LPB
 | |
5LPZ
 | |
5TVZ
 | | Solution NMR structure of Saccharomyces cerevisiae Pom152 Ig-like repeat, residues 718-820 | | Descriptor: | Nucleoporin POM152 | | Authors: | Dutta, K, Sampathkumar, P, Cowburn, D, Almo, S.C, Rout, M.P, Fernandez-Martinez, J. | | Deposit date: | 2016-11-10 | | Release date: | 2017-02-22 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | Molecular Architecture of the Major Membrane Ring Component of the Nuclear Pore Complex.
Structure, 25, 2017
|
|
8RXR
 | | Crystal structure of VPS34 in complex with inhibitor SB02024 | | Descriptor: | 4-[(3R)-3-methylmorpholin-4-yl]-2-[(2R)-2-(trifluoromethyl)piperidin-1-yl]-3H-pyridin-6-one, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | | Authors: | Tresaugues, L, Yu, Y, Bogdan, M, Parpal, S, Silvander, C, Lindstrom, J, Simeon, J, Timson, M.J, Al-Hashimi, H, Smith, B.D, Flynn, D.L, Viklund, J, Martinsson, J, De Milito, A, Andersson, M. | | Deposit date: | 2024-02-07 | | Release date: | 2024-03-20 | | Last modified: | 2024-08-21 | | Method: | X-RAY DIFFRACTION (2.06 Å) | | Cite: | Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy.
Mol Oncol, 18, 2024
|
|
5LPV
 | |
6ETJ
 | | HUMAN PFKFB3 IN COMPLEX WITH KAN0438241 | | Descriptor: | 4-[[3-(5-fluoranyl-2-oxidanyl-phenyl)phenyl]sulfonylamino]-2-oxidanyl-benzoic acid, 6-O-phosphono-beta-D-fructofuranose, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, ... | | Authors: | Gustafsson, N.M.S, Lundback, T, Farnegardh, K, Groth, P, Wiitta, E, Jonsson, M, Hallberg, K, Pennisi, R, Huguet Ninou, A, Martinsson, J, Norstrom, C, Schultz, J, Andersson, M, Markova, N, Marttila, P, Norin, M, Olin, T, Helleday, T. | | Deposit date: | 2017-10-26 | | Release date: | 2018-11-07 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Targeting PFKFB3 radiosensitizes cancer cells and suppresses homologous recombination.
Nat Commun, 9, 2018
|
|
5LPW
 | |
7N85
 | | Inner ring spoke from the isolated yeast NPC | | Descriptor: | Nucleoporin ASM4, Nucleoporin NIC96, Nucleoporin NSP1, ... | | Authors: | Akey, C.W, Rout, M.P, Ouch, C, Echevarria, I, Fernandez-Martinez, J, Nudelman, I. | | Deposit date: | 2021-06-13 | | Release date: | 2022-01-26 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (7.6 Å) | | Cite: | Comprehensive structure and functional adaptations of the yeast nuclear pore complex.
Cell, 185, 2022
|
|
7N84
 | | Double nuclear outer ring from the isolated yeast NPC | | Descriptor: | Nucleoporin 145c, Nucleoporin NUP120, Nucleoporin NUP133, ... | | Authors: | Akey, C.W, Rout, M.P, Ouch, C, Echevarria, I, Fernandez-Martinez, J, Nudelman, I. | | Deposit date: | 2021-06-13 | | Release date: | 2022-01-26 | | Last modified: | 2024-06-05 | | Method: | ELECTRON MICROSCOPY (11.6 Å) | | Cite: | Comprehensive structure and functional adaptations of the yeast nuclear pore complex.
Cell, 185, 2022
|
|
8T9L
 | | Pom34-Pom152 membrane attachment site yeast NPC | | Descriptor: | Nucleoporin POM152, Nucleoporin POM34 | | Authors: | Akey, C.W, Echeverria, I, Ouch, C, Fernandez-Martinez, J, Rout, M.P. | | Deposit date: | 2023-06-24 | | Release date: | 2023-10-11 | | Method: | ELECTRON MICROSCOPY (7 Å) | | Cite: | Implications of a multiscale structure of the yeast nuclear pore complex.
Mol.Cell, 83, 2023
|
|
8TJ5
 | | Inner spoke ring of the yeast NPC | | Descriptor: | Nucleoporin 59, Nucleoporin NIC96, Nucleoporin NSP1, ... | | Authors: | Akey, C.W, Echeverria, I, Ouch, C, Fernandez-Martinez, J, Rout, M.P. | | Deposit date: | 2023-07-20 | | Release date: | 2023-10-11 | | Method: | ELECTRON MICROSCOPY (6.6 Å) | | Cite: | Implications of a multiscale structure of the yeast nuclear pore complex.
Mol.Cell, 83, 2023
|
|
8TIE
 | | Double nuclear outer ring of Nup84-complexes from the yeast NPC | | Descriptor: | NUP133 isoform 1, NUP145 isoform 1, Nucleoporin NUP120, ... | | Authors: | Akey, C.W, Echeverria, I, Ouch, C, Fernandez-Martinez, J, Rout, M.P. | | Deposit date: | 2023-07-19 | | Release date: | 2023-10-11 | | Method: | ELECTRON MICROSCOPY (8.1 Å) | | Cite: | Implications of a multiscale structure of the yeast nuclear pore complex.
Mol.Cell, 83, 2023
|
|
5C9B
 | | Crystal structure of a retropepsin-like aspartic protease from Rickettsia conorii | | Descriptor: | ApRick protease | | Authors: | Li, M, Gustchina, A, Cruz, R, Simoes, M, Curto, P, Martinez, J, Faro, C, Simoes, I, Wlodawer, A. | | Deposit date: | 2015-06-26 | | Release date: | 2015-10-14 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure of RC1339/APRc from Rickettsia conorii, a retropepsin-like aspartic protease.
Acta Crystallogr. D Biol. Crystallogr., 71, 2015
|
|
5C9D
 | | Crystal structure of a retropepsin-like aspartic protease from Rickettsia conorii | | Descriptor: | ApRick protease, SODIUM ION | | Authors: | Li, M, Gustchina, A, Cruz, R, Simoes, M, Curto, P, Martinez, J, Faro, C, Simoes, I, Wlodawer, A. | | Deposit date: | 2015-06-26 | | Release date: | 2015-10-14 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.59 Å) | | Cite: | Structure of RC1339/APRc from Rickettsia conorii, a retropepsin-like aspartic protease
Acta Crystallogr.,Sect.D, 71, 2015
|
|
5C9F
 | | Crystal structure of a retropepsin-like aspartic protease from Rickettsia conorii | | Descriptor: | ApRick protease, CHLORIDE ION, SODIUM ION | | Authors: | Li, M, Gustchina, A, Cruz, R, Simoes, M, Curto, P, Martinez, J, Faro, C, Simoes, I, Wlodawer, A. | | Deposit date: | 2015-06-26 | | Release date: | 2015-10-14 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of RC1339/APRc from Rickettsia conorii, a retropepsin-like aspartic protease.
Acta Crystallogr. D Biol. Crystallogr., 71, 2015
|
|
8ORJ
 | | Cryo-EM structure of human tRNA ligase RTCB in complex with human PYROXD1. | | Descriptor: | DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, MAGNESIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | | Authors: | Loeff, L, Kroupova, A, Asanovic, I, Boneberg, F, Pfleiderer, M.M, Ferdigg, A, Ackle, F, Martinez, J, Jinek, M. | | Deposit date: | 2023-04-14 | | Release date: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Mechanistic basis for oxidative stress protection of the human tRNA ligase complex by the oxidoreductase PYROXD1
BioRxiv, 2023
|
|
7Z67
 | |
7Z66
 | |
3OG9
 | | Structure of YahD with Malic acid | | Descriptor: | D-MALATE, protein yahD a copper inducible hydrolase | | Authors: | Martinez Font, J, Mancini, S, Tauberger, E, Moniot, S. | | Deposit date: | 2010-08-16 | | Release date: | 2010-12-15 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Regulation and structure of YahD, a copper inducible alpha/beta hydrolase of Lactococcus lactis IL1403
Fems Microbiol.Lett., 314, 2011
|
|
