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Crystal structure of SARS-CoV-2 spike protein receptor-binding domain complexed with a pre-pandemic antibody S-B8 Fab
Descriptor:	1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, S-B8 Fab heavy chain, ...
Authors:	Liu, H, Zhu, X, Wilson, I.A.
Deposit date:	2020-11-04
Release date:	2021-09-22
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.251 Å)
Cite:	Neutralizing Antibodies to SARS-CoV-2 Selected from a Human Antibody Library Constructed Decades Ago. Adv Sci, 9, 2022

7KN4

Crystal structure of SARS-CoV-2 spike protein receptor-binding domain complexed with a pre-pandemic antibody S-E6 Fab
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, S-E6 Fab heavy chain, S-E6 Fab light chain, ...
Authors:	Liu, H, Wilson, I.A.
Deposit date:	2020-11-04
Release date:	2021-09-22
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Neutralizing Antibodies to SARS-CoV-2 Selected from a Human Antibody Library Constructed Decades Ago. Adv Sci, 9, 2022

1IGF

CRYSTAL STRUCTURES OF AN ANTIBODY TO A PEPTIDE AND ITS COMPLEX WITH PEPTIDE ANTIGEN AT 2.8 ANGSTROMS
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, IGG1-KAPPA B13I2 FAB (HEAVY CHAIN), IGG1-KAPPA B13I2 FAB (LIGHT CHAIN)
Authors:	Stanfield, R.L, Wilson, I.A.
Deposit date:	1991-03-21
Release date:	1992-04-15
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Crystal structures of an antibody to a peptide and its complex with peptide antigen at 2.8 A. Science, 248, 1990

6NHR

Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin HA2 I45F mutant
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, ...
Authors:	Wu, N.C, Wilson, I.A.
Deposit date:	2018-12-23
Release date:	2020-04-15
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Different genetic barriers for resistance to HA stem antibodies in influenza H3 and H1 viruses. Science, 368, 2020

6NHP

Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin HA2 I45T mutant
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, ...
Authors:	Wu, N.C, Wilson, I.A.
Deposit date:	2018-12-23
Release date:	2020-04-15
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.25 Å)
Cite:	Different genetic barriers for resistance to HA stem antibodies in influenza H3 and H1 viruses. Science, 368, 2020

6NHQ

Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin HA2 I45M mutant
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, ...
Authors:	Wu, N.C, Wilson, I.A.
Deposit date:	2018-12-23
Release date:	2020-04-15
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Different genetic barriers for resistance to HA stem antibodies in influenza H3 and H1 viruses. Science, 368, 2020

4FQR

Crystal structure of broadly neutralizing antibody C05 bound to H3 influenza hemagglutinin
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Broadly neutralizing antibody C05, ...
Authors:	Ekiert, D.C, Wilson, I.A.
Deposit date:	2012-06-25
Release date:	2012-09-19
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (4.1 Å)
Cite:	Cross-neutralization of influenza A viruses mediated by a single antibody loop. Nature, 489, 2012

4FNL

Crystal structure of broadly neutralizing antibody C05
Descriptor:	2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Antibody C05, Heavy Chain, ...
Authors:	Ekiert, D.C, Wilson, I.A.
Deposit date:	2012-06-19
Release date:	2012-09-19
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.297 Å)
Cite:	Cross-neutralization of influenza A viruses mediated by a single antibody loop. Nature, 489, 2012

4FNK

Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ...
Authors:	Ekiert, D.C, Wilson, I.A.
Deposit date:	2012-06-19
Release date:	2012-09-19
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (1.901 Å)
Cite:	Cross-neutralization of influenza A viruses mediated by a single antibody loop. Nature, 489, 2012

4FP8

Crystal structure of broadly neutralizing antibody C05 bound to H3 influenza hemagglutinin, HA1 subunit
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody C05, ...
Authors:	Ekiert, D.C, Wilson, I.A.
Deposit date:	2012-06-21
Release date:	2012-09-19
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.947 Å)
Cite:	Cross-neutralization of influenza A viruses mediated by a single antibody loop. Nature, 489, 2012

1FL3

CRYSTAL STRUCTURE OF THE BLUE FLUORESCENT ANTIBODY (19G2) IN COMPLEX WITH STILBENE HAPTEN AT 277K
Descriptor:	4-(4-STYRYL-PHENYLCARBAMOYL)-BUTYRIC ACID, BLUE FLUORESCENT ANTIBODY (19G2)-HEAVY CHAIN, BLUE FLUORESCENT ANTIBODY (19G2)-LIGHT CHAIN
Authors:	Stevens, R.C, Beuscher IV, A.E.
Deposit date:	2000-08-11
Release date:	2000-11-01
Last modified:	2018-01-31
Method:	X-RAY DIFFRACTION (2.45 Å)
Cite:	Blue-fluorescent antibodies. Science, 290, 2000

1AXT

IMMUNE VERSUS NATURAL SELECTION: ANTIBODY ALDOLASES WITH THE RATES OF NATURAL ENZYMES
Descriptor:	IMMUNOGLOBULIN IGG2A
Authors:	Heine, A, Wilson, I.A.
Deposit date:	1997-10-20
Release date:	1998-10-28
Last modified:	2023-08-02
Method:	X-RAY DIFFRACTION (2.15 Å)
Cite:	Immune versus natural selection: antibody aldolases with enzymic rates but broader scope. Science, 278, 1997

6BKQ

Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin E190D mutant in complex with 6'-SLN
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ...
Authors:	Wu, N.C, Wilson, I.A.
Deposit date:	2017-11-09
Release date:	2018-02-28
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.25 Å)
Cite:	A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site. Nat Commun, 9, 2018

6BKO

Crystal structure of the A/Wyoming/3/2003 (H3N2) influenza virus hemagglutinin D190E mutant apo form
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ...
Authors:	Wu, N.C, Wilson, I.A.
Deposit date:	2017-11-09
Release date:	2018-02-28
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site. Nat Commun, 9, 2018

6BKP

Crystal structure of the A/Michigan/15/2014 (H3N2) influenza virus hemagglutinin apo form
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ...
Authors:	Wu, N.C, Wilson, I.A.
Deposit date:	2017-11-09
Release date:	2018-02-28
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site. Nat Commun, 9, 2018

6BKN

Crystal structure of the A/Wyoming/3/2003 (H3N2) influenza virus hemagglutinin apo form
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ...
Authors:	Wu, N.C, Wilson, I.A.
Deposit date:	2017-11-09
Release date:	2018-02-28
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site. Nat Commun, 9, 2018

6BKR

Crystal structure of the A/Wyoming/3/2003 (H3N2) influenza virus hemagglutinin in complex with 6'-SLN
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, ...
Authors:	Wu, N.C, Wilson, I.A.
Deposit date:	2017-11-09
Release date:	2018-02-28
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (1.76 Å)
Cite:	A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site. Nat Commun, 9, 2018

6BKM

Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin E190D mutant apo form
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ...
Authors:	Wu, N.C, Wilson, I.A.
Deposit date:	2017-11-09
Release date:	2018-02-28
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site. Nat Commun, 9, 2018

6BKS

Crystal structure of the A/Wyoming/3/2003 (H3N2) influenza virus hemagglutinin D190E mutant in complex with 6'-SLN
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ...
Authors:	Wu, N.C, Wilson, I.A.
Deposit date:	2017-11-09
Release date:	2018-02-28
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site. Nat Commun, 9, 2018

6BKT

Crystal structure of the A/Michigan/15/2014 (H3N2) influenza virus hemagglutinin in complex with 6'-SLN
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DI(HYDROXYETHYL)ETHER, ...
Authors:	Wu, N.C, Wilson, I.A.
Deposit date:	2017-11-09
Release date:	2018-02-28
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	A complex epistatic network limits the mutational reversibility in the influenza hemagglutinin receptor-binding site. Nat Commun, 9, 2018

1T4K

Crystal Structure of Unliganded Aldolase Antibody 93F3 Fab
Descriptor:	IMMUNOGLOBULIN IGG1, HEAVY CHAIN, KAPPA LIGHT CHAIN, ...
Authors:	Zhu, X, Wilson, I.A.
Deposit date:	2004-04-29
Release date:	2004-11-02
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	The Origin of Enantioselectivity in Aldolase Antibodies: Crystal Structure, Site-directed Mutagenesis, and Computational Analysis J.Mol.Biol., 343, 2004

5UMN

Crystal structure of C05 VPGSGW mutant bound to H3 influenza hemagglutinin, HA1 subunit
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody C05 VPGSGW mutant, heavy chain, ...
Authors:	Wu, N.C, Wilson, I.A.
Deposit date:	2017-01-27
Release date:	2017-05-24
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (1.97 Å)
Cite:	In vitro evolution of an influenza broadly neutralizing antibody is modulated by hemagglutinin receptor specificity. Nat Commun, 8, 2017

5VTR

Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225L/L226S mutant in complex with 6'-SLN
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, ...
Authors:	Wu, N.C, Wilson, I.A.
Deposit date:	2017-05-18
Release date:	2017-06-28
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin. Cell Host Microbe, 21, 2017

5VU4

Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225Q/L226A mutant in complex with 6'-SLN
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, ...
Authors:	Wu, N.C, Wilson, I.A.
Deposit date:	2017-05-18
Release date:	2017-06-28
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.25 Å)
Cite:	Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin. Cell Host Microbe, 21, 2017

5VTW

Crystal structure of the A/Hong Kong/1/1968 (H3N2) influenza virus hemagglutinin G225M/L226T/S228A mutant in complex with 6'-SLN
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin HA1 chain, ...
Authors:	Wu, N.C, Wilson, I.A.
Deposit date:	2017-05-18
Release date:	2017-06-28
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (2.35 Å)
Cite:	Diversity of Functionally Permissive Sequences in the Receptor-Binding Site of Influenza Hemagglutinin. Cell Host Microbe, 21, 2017

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