6DFC
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![BU of 6dfc by Molmil](/molmil-images/mine/6dfc) | Kaiso (ZBTB33) zinc finger DNA binding domain in complex with the specific Kaiso binding sequence (KBS) with a T-to-U substitution | Descriptor: | CHLORIDE ION, DNA (5'-D(*CP*GP*TP*TP*AP*TP*TP*GP*GP*CP*AP*AP*GP*AP*AP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*TP*TP*CP*UP*TP*GP*CP*CP*AP*AP*TP*AP*AP*CP*G)-3'), ... | Authors: | Nikolova, E.N, Stanfield, R.L, Dyson, H.J, Wright, P.E. | Deposit date: | 2018-05-14 | Release date: | 2019-05-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | A conformational switch in the zinc finger protein Kaiso mediates differential readout of specific and methylated DNA sequences. Biochemistry, 2020
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5W3Q
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![BU of 5w3q by Molmil](/molmil-images/mine/5w3q) | L28F E.coli DHFR in complex with NADPH | Descriptor: | CALCIUM ION, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Oyen, D, Wright, P.E, Wilson, I.A. | Deposit date: | 2017-06-08 | Release date: | 2017-08-09 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.401 Å) | Cite: | Defining the Structural Basis for Allosteric Product Release from E. coli Dihydrofolate Reductase Using NMR Relaxation Dispersion. J. Am. Chem. Soc., 139, 2017
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5VMV
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![BU of 5vmv by Molmil](/molmil-images/mine/5vmv) | Kaiso (ZBTB33) zinc finger DNA binding domain in complex with its double CpG-methylated DNA consensus binding site | Descriptor: | CHLORIDE ION, DNA (5'-D(*TP*GP*CP*TP*TP*CP*TP*(5CM)P*GP*(5CM)P*GP*AP*GP*AP*AP*GP*CP*A)-3'), Transcriptional regulator Kaiso, ... | Authors: | Nikolova, E.N, Stanfield, R.L, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E. | Deposit date: | 2017-04-28 | Release date: | 2018-04-04 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.313 Å) | Cite: | CH···O Hydrogen Bonds Mediate Highly Specific Recognition of Methylated CpG Sites by the Zinc Finger Protein Kaiso. Biochemistry, 57, 2018
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5VMX
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![BU of 5vmx by Molmil](/molmil-images/mine/5vmx) | Kaiso (ZBTB33) zinc finger DNA binding domain in complex with a hemi CpG-methylated DNA resembling the specific Kaiso binding sequence (KBS) | Descriptor: | CHLORIDE ION, DNA (5'-D(*CP*GP*TP*TP*AP*TP*TP*CP*GP*CP*GP*GP*GP*AP*AP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*TP*TP*CP*CP*(5CM)P*GP*(5CM)P*GP*AP*AP*TP*AP*AP*CP*G)-3'), ... | Authors: | Nikolova, E.N, Stanfield, R.L, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E. | Deposit date: | 2017-04-28 | Release date: | 2018-04-04 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | CH···O Hydrogen Bonds Mediate Highly Specific Recognition of Methylated CpG Sites by the Zinc Finger Protein Kaiso. Biochemistry, 57, 2018
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1RGO
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![BU of 1rgo by Molmil](/molmil-images/mine/1rgo) | Structural Basis for Recognition of the mRNA Class II AU-Rich Element by the Tandem Zinc Finger Domain of TIS11d | Descriptor: | Butyrate response factor 2, RNA (5'-R(*UP*UP*AP*UP*UP*UP*AP*UP*U)-3'), ZINC ION | Authors: | Hudson, B.P, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E. | Deposit date: | 2003-11-12 | Release date: | 2004-03-02 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d. NAT.STRUCT.MOL.BIOL., 11, 2004
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1R8U
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![BU of 1r8u by Molmil](/molmil-images/mine/1r8u) | NMR structure of CBP TAZ1/CITED2 complex | Descriptor: | CREB-binding protein, Cbp/p300-interacting transactivator 2, ZINC ION | Authors: | De Guzman, R.N, Martinez-Yamout, M, Dyson, H.J, Wright, P.E. | Deposit date: | 2003-10-28 | Release date: | 2004-03-23 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Interaction of the TAZ1 domain of the CREB-binding protein with the activation domain of CITED2: regulation by competition between intrinsically unstructured ligands for non-identical binding sites. J.Biol.Chem., 279, 2004
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1RXR
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![BU of 1rxr by Molmil](/molmil-images/mine/1rxr) | HIGH RESOLUTION SOLUTION STRUCTURE OF THE RETINOID X RECEPTOR DNA BINDING DOMAIN, NMR, 20 STRUCTURE | Descriptor: | RETINOIC ACID RECEPTOR-ALPHA, ZINC ION | Authors: | Holmbeck, S.M.A, Foster, M.P, Casimiro, D.R, Sem, D.S, Dyson, H.J, Wright, P.E. | Deposit date: | 1998-06-12 | Release date: | 1998-11-11 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | High-resolution solution structure of the retinoid X receptor DNA-binding domain. J.Mol.Biol., 281, 1998
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1POU
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![BU of 1pou by Molmil](/molmil-images/mine/1pou) | THE SOLUTION STRUCTURE OF THE OCT-1 POU-SPECIFIC DOMAIN REVEALS A STRIKING SIMILARITY TO THE BACTERIOPHAGE LAMBDA REPRESSOR DNA-BINDING DOMAIN | Descriptor: | OCT-1 | Authors: | Assa-Munt, N, Mortishire-Smith, R.J, Aurora, R, Herr, W, Wright, P.E. | Deposit date: | 1993-06-14 | Release date: | 1994-10-15 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The solution structure of the Oct-1 POU-specific domain reveals a striking similarity to the bacteriophage lambda repressor DNA-binding domain. Cell(Cambridge,Mass.), 73, 1993
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5VMU
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![BU of 5vmu by Molmil](/molmil-images/mine/5vmu) | Kaiso (ZBTB33) zinc finger DNA binding domain in complex with a double CpG-methylated DNA resembling the specific Kaiso binding sequence (KBS) | Descriptor: | CHLORIDE ION, DNA (5'-D(*CP*GP*TP*TP*AP*TP*TP*(5CM)P*GP*(5CM)P*GP*GP*GP*AP*AP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*TP*TP*CP*CP*(5CM)P*GP*(5CM)P*GP*AP*AP*TP*AP*AP*CP*G)-3'), ... | Authors: | Nikolova, E.N, Stanfield, R.L, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E. | Deposit date: | 2017-04-28 | Release date: | 2018-04-04 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.346 Å) | Cite: | CH···O Hydrogen Bonds Mediate Highly Specific Recognition of Methylated CpG Sites by the Zinc Finger Protein Kaiso. Biochemistry, 57, 2018
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5VMZ
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![BU of 5vmz by Molmil](/molmil-images/mine/5vmz) | Kaiso (ZBTB33) E535Q mutant zinc finger DNA binding domain in complex with a double CpG-methylated DNA resembling the specific Kaiso binding sequence (KBS) | Descriptor: | CHLORIDE ION, DNA (5'-D(*CP*GP*TP*TP*AP*TP*TP*(5CM)P*GP*(5CM)P*GP*GP*GP*AP*AP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*TP*TP*CP*CP*(5CM)P*GP*(5CM)P*GP*AP*AP*TP*AP*AP*CP*G)-3'), ... | Authors: | Nikolova, E.N, Stanfield, R.L, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E. | Deposit date: | 2017-04-28 | Release date: | 2018-04-04 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.319 Å) | Cite: | CH···O Hydrogen Bonds Mediate Highly Specific Recognition of Methylated CpG Sites by the Zinc Finger Protein Kaiso. Biochemistry, 57, 2018
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5VMY
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![BU of 5vmy by Molmil](/molmil-images/mine/5vmy) | Kaiso (ZBTB33) zinc finger DNA binding domain in complex with a hemi CpG-methylated DNA resembling the specific Kaiso binding sequence (KBS) | Descriptor: | CHLORIDE ION, DNA (5'-D(*CP*GP*TP*TP*AP*TP*TP*CP*GP*CP*GP*GP*GP*AP*AP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*TP*TP*CP*CP*(5CM)P*GP*(5CM)P*GP*AP*AP*TP*AP*AP*CP*G)-3'), ... | Authors: | Nikolova, E.N, Stanfield, R.L, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E. | Deposit date: | 2017-04-28 | Release date: | 2018-04-04 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.002 Å) | Cite: | CH···O Hydrogen Bonds Mediate Highly Specific Recognition of Methylated CpG Sites by the Zinc Finger Protein Kaiso. Biochemistry, 57, 2018
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5VMW
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![BU of 5vmw by Molmil](/molmil-images/mine/5vmw) | Kaiso (ZBTB33) zinc finger DNA binding domain in complex with a double CpG-methylated DNA resembling the specific Kaiso binding sequence (KBS) | Descriptor: | CHLORIDE ION, DNA (5'-D(*CP*GP*TP*TP*AP*TP*TP*(5CM)P*GP*(5CM)P*GP*GP*GP*AP*AP*GP*CP*A)-3'), DNA (5'-D(*TP*GP*CP*TP*TP*CP*CP*(5CM)P*GP*(5CM)P*GP*AP*AP*TP*AP*AP*CP*G)-3'), ... | Authors: | Nikolova, E.N, Stanfield, R.L, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E. | Deposit date: | 2017-04-28 | Release date: | 2018-04-04 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.397 Å) | Cite: | CH···O Hydrogen Bonds Mediate Highly Specific Recognition of Methylated CpG Sites by the Zinc Finger Protein Kaiso. Biochemistry, 57, 2018
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1SB0
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![BU of 1sb0 by Molmil](/molmil-images/mine/1sb0) | Solution structure of the KIX domain of CBP bound to the transactivation domain of c-Myb | Descriptor: | protein CBP, protein c-Myb | Authors: | Zor, T, De Guzman, R.N, Dyson, H.J, Wright, P.E. | Deposit date: | 2004-02-09 | Release date: | 2004-04-13 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution Structure of the KIX Domain of CBP Bound to the Transactivation
Domain of c-Myb J.Mol.Biol., 337, 2004
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5HP0
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![BU of 5hp0 by Molmil](/molmil-images/mine/5hp0) | Solution Structure of TAZ2-p53AD2 | Descriptor: | CREB-binding protein,Cellular tumor antigen p53 fusion protein, ZINC ION | Authors: | Krois, A.S, Ferreon, J.C, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E. | Deposit date: | 2016-01-19 | Release date: | 2016-03-16 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein. Proc.Natl.Acad.Sci.USA, 113, 2016
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5HPD
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![BU of 5hpd by Molmil](/molmil-images/mine/5hpd) | Solution Structure of TAZ2-p53TAD | Descriptor: | CREB-binding protein,Cellular tumor antigen p53 fusion protein, ZINC ION | Authors: | Krois, A.S, Ferreon, J.C, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E. | Deposit date: | 2016-01-20 | Release date: | 2016-03-16 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein. Proc.Natl.Acad.Sci.USA, 113, 2016
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5HOU
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![BU of 5hou by Molmil](/molmil-images/mine/5hou) | Solution Structure of p53TAD-TAZ1 | Descriptor: | Cellular tumor antigen p53,CREB-binding protein fusion protein, ZINC ION | Authors: | Krois, A.S, Ferreon, J.C, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E. | Deposit date: | 2016-01-19 | Release date: | 2016-03-16 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Recognition of the disordered p53 transactivation domain by the transcriptional adapter zinc finger domains of CREB-binding protein. Proc.Natl.Acad.Sci.USA, 113, 2016
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1ZU1
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![BU of 1zu1 by Molmil](/molmil-images/mine/1zu1) | Solution Structure of the N-terminal Zinc Fingers of the Xenopus laevis double stranded RNA binding protein ZFa | Descriptor: | RNA binding protein ZFa, ZINC ION | Authors: | Moller, H.M, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E. | Deposit date: | 2005-05-29 | Release date: | 2005-09-20 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution structure of the N-terminal zinc fingers of the Xenopus laevis double-stranded RNA-binding protein ZFa J.Mol.Biol., 351, 2005
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2AGH
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![BU of 2agh by Molmil](/molmil-images/mine/2agh) | Structural basis for cooperative transcription factor binding to the CBP coactivator | Descriptor: | Crebbp protein, Myb proto-oncogene protein, Zinc finger protein HRX | Authors: | De Guzman, R.N, Goto, N.K, Dyson, H.J, Wright, P.E. | Deposit date: | 2005-07-26 | Release date: | 2005-11-22 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structural Basis for Cooperative Transcription Factor Binding to the CBP Coactivator J.Mol.Biol., 355, 2006
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2AVX
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![BU of 2avx by Molmil](/molmil-images/mine/2avx) | solution structure of E coli SdiA1-171 | Descriptor: | N-(2-OXOTETRAHYDROFURAN-3-YL)OCTANAMIDE, Regulatory protein sdiA | Authors: | Yao, Y, Martinez-Yamout, M.A, Dickerson, T.J, Brogan, A.P, Wright, P.E, Dyson, H.J. | Deposit date: | 2005-08-30 | Release date: | 2006-06-20 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of the Escherichia coli quorum sensing protein SdiA: activation of the folding switch by acyl homoserine lactones. J.Mol.Biol., 355, 2006
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1LO1
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![BU of 1lo1 by Molmil](/molmil-images/mine/1lo1) | ESTROGEN RELATED RECEPTOR 2 DNA BINDING DOMAIN IN COMPLEX WITH DNA | Descriptor: | 5'-D(*CP*GP*TP*GP*AP*CP*CP*TP*TP*GP*AP*GP*C)-3', 5'-D(*GP*CP*TP*CP*AP*AP*GP*GP*TP*CP*AP*CP*G)-3', Steroid hormone receptor ERR2, ... | Authors: | Gearhart, M.D, Holmbeck, S.M.A, Evans, R.M, Dyson, H.J, Wright, P.E. | Deposit date: | 2002-05-05 | Release date: | 2003-04-22 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Monomeric Complex of Human Orphan Estrogen Related Receptor-2 with DNA: A Pseudo-dimer Interface Mediates Extended Half-site Recognition J.Mol.Biol., 327, 2003
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1KDX
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![BU of 1kdx by Molmil](/molmil-images/mine/1kdx) | KIX DOMAIN OF MOUSE CBP (CREB BINDING PROTEIN) IN COMPLEX WITH PHOSPHORYLATED KINASE INDUCIBLE DOMAIN (PKID) OF RAT CREB (CYCLIC AMP RESPONSE ELEMENT BINDING PROTEIN), NMR 17 STRUCTURES | Descriptor: | CBP, CREB | Authors: | Radhakrishnan, I, Perez-Alvarado, G.C, Dyson, H.J, Wright, P.E. | Deposit date: | 1997-09-16 | Release date: | 1998-11-25 | Last modified: | 2021-11-03 | Method: | SOLUTION NMR | Cite: | Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator:coactivator interactions. Cell(Cambridge,Mass.), 91, 1997
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1L8C
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![BU of 1l8c by Molmil](/molmil-images/mine/1l8c) | STRUCTURAL BASIS FOR HIF-1ALPHA/CBP RECOGNITION IN THE CELLULAR HYPOXIC RESPONSE | Descriptor: | CREB-binding protein, Hypoxia-inducible factor 1 alpha, ZINC ION | Authors: | Dames, S.A, Martinez-Yamout, M, De Guzman, R.N, Dyson, H.J, Wright, P.E. | Deposit date: | 2002-03-19 | Release date: | 2002-04-10 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structural basis for Hif-1 alpha /CBP recognition in the cellular hypoxic response. Proc.Natl.Acad.Sci.USA, 99, 2002
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1NO8
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![BU of 1no8 by Molmil](/molmil-images/mine/1no8) | SOLUTION STRUCTURE OF THE NUCLEAR FACTOR ALY RBD DOMAIN | Descriptor: | ALY | Authors: | Perez-Alvarado, G.C, Martinez-Yamout, M, Allen, M.M, Grosschedl, R, Dyson, H.J, Wright, P.E. | Deposit date: | 2003-01-15 | Release date: | 2003-08-12 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Structure of the Nuclear Factor ALY: Insights into Post-Transcriptional
Regulatory and mRNA Nuclear Export Processes Biochemistry, 42, 2003
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2KA4
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![BU of 2ka4 by Molmil](/molmil-images/mine/2ka4) | NMR structure of the CBP-TAZ1/STAT2-TAD complex | Descriptor: | Crebbp protein, Signal transducer and activator of transcription 2, ZINC ION | Authors: | Wojciak, J.M, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E. | Deposit date: | 2008-10-30 | Release date: | 2009-04-21 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Structural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domains Embo J., 28, 2009
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2KA6
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![BU of 2ka6 by Molmil](/molmil-images/mine/2ka6) | NMR structure of the CBP-TAZ2/STAT1-TAD complex | Descriptor: | CREB-binding protein, Signal transducer and activator of transcription 1-alpha/beta, ZINC ION | Authors: | Wojciak, J.M, Martinez-Yamout, M.A, Dyson, H.J, Wright, P.E. | Deposit date: | 2008-10-30 | Release date: | 2009-04-07 | Last modified: | 2024-05-08 | Method: | SOLUTION NMR | Cite: | Structural basis for recruitment of CBP/p300 coactivators by STAT1 and STAT2 transactivation domains. Embo J., 28, 2009
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