3RUO
 
 | | Complex structure of HevB EV93 main protease 3C with Rupintrivir (AG7088) | | Descriptor: | 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER, CHLORIDE ION, HEVB EV93 3C PROTEASE, ... | | Authors: | Kaczmarska, Z, Janowski, R, Costenaro, L, Coutard, B, Norder, H, Canard, B, Coll, M. | | Deposit date: | 2011-05-05 | | Release date: | 2011-09-07 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Structural Basis for Antiviral Inhibition of the Main Protease, 3C, from Human Enterovirus 93.
J.Virol., 85, 2011
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5NFY
 | | SARS-CoV nsp10/nsp14 dynamic complex | | Descriptor: | DI(HYDROXYETHYL)ETHER, Polyprotein 1ab, ZINC ION | | Authors: | Ferron, F, Gluais, L, Vonrhein, C, Bricogne, G, Canard, B, Imbert, I. | | Deposit date: | 2017-03-16 | | Release date: | 2018-01-10 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (3.382 Å) | | Cite: | Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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3GQE
 | | Crystal structure of macro domain of Venezuelan Equine Encephalitis virus | | Descriptor: | BICINE, Non-structural protein 3 | | Authors: | Jamal, S, Malet, H, Coutard, B, Canard, B. | | Deposit date: | 2009-03-24 | | Release date: | 2009-07-21 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket
J.Virol., 83, 2009
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3GQO
 | | Crystal structure of macro domain of Venezuelan Equine Encephalitis virus in complex with ADP-ribose | | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, Non-structural protein 3 | | Authors: | Malet, H, Jamal, S, Coutard, B, Ferron, F, Canard, B. | | Deposit date: | 2009-03-24 | | Release date: | 2009-07-21 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket
J.Virol., 83, 2009
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3GPQ
 | | Crystal structure of macro domain of Chikungunya virus in complex with RNA | | Descriptor: | Non-structural protein 3, RNA (5'-R(*AP*AP*A)-3') | | Authors: | Malet, H, Jamal, S, Coutard, B, Canard, B. | | Deposit date: | 2009-03-23 | | Release date: | 2009-07-21 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket
J.Virol., 83, 2009
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3GPO
 | | Crystal structure of macro domain of Chikungunya virus in complex with ADP-ribose | | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, Non-structural protein 3 | | Authors: | Malet, H, Jamal, S, Coutard, B, Canard, B. | | Deposit date: | 2009-03-23 | | Release date: | 2009-07-21 | | Last modified: | 2024-11-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket
J.Virol., 83, 2009
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3GPG
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5LS4
 | | Mopeia virus exonuclease domain complexed with Calcium | | Descriptor: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, Nucleoprotein, ... | | Authors: | Yekwa, E.L, Canard, B, Ferron, F. | | Deposit date: | 2016-08-22 | | Release date: | 2017-07-05 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.469 Å) | | Cite: | Activity inhibition and crystal polymorphism induced by active-site metal swapping.
Acta Crystallogr D Struct Biol, 73, 2017
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5LTN
 | | Crystal structure of Lymphocytic choriomeningitis mammarenavirus endonuclease complexed with DPBA | | Descriptor: | 2-4-DIOXO-4-PHENYLBUTANOIC ACID, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Saez-Ayala, M, Yekwa, E.L, Canard, B, Alvarez, K, Ferron, F. | | Deposit date: | 2016-09-07 | | Release date: | 2017-09-13 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Crystal structures of Lymphocytic choriomeningitis virusendonuclease domain complexed with diketo-acid ligands.
Iucrj, 5, 2018
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5LTF
 | | Crystal structure of Lymphocytic choriomeningitis mammarenavirus endonuclease complexed with catalytic ions | | Descriptor: | MAGNESIUM ION, RNA-directed RNA polymerase L | | Authors: | Saez-Ayala, M, Yekwa, E.L, Canard, B, Ferron, F. | | Deposit date: | 2016-09-06 | | Release date: | 2017-09-13 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.43 Å) | | Cite: | Crystal structures ofLymphocytic choriomeningitis virusendonuclease domain complexed with diketo-acid ligands.
IUCrJ, 5, 2018
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5LRP
 | | Mopeia Virus Exonuclease domain complexed with Magnesium | | Descriptor: | MAGNESIUM ION, Nucleoprotein, ZINC ION | | Authors: | Yekwa, E.L, Khourieh, J, Canard, B, Ferron, F. | | Deposit date: | 2016-08-19 | | Release date: | 2017-07-05 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.941 Å) | | Cite: | Activity inhibition and crystal polymorphism induced by active-site metal swapping.
Acta Crystallogr D Struct Biol, 73, 2017
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5LTS
 | | Crystal structure of Lymphocytic choriomeningitis mammarenavirus endonuclease Mutant D118A | | Descriptor: | CHLORIDE ION, GLYCEROL, RNA-directed RNA polymerase L, ... | | Authors: | Saez-Ayala, M, Yekwa, E.L, Canard, B, Alvarez, K, Ferron, F. | | Deposit date: | 2016-09-07 | | Release date: | 2017-09-13 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.51 Å) | | Cite: | Crystal structures ofLymphocytic choriomeningitis virusendonuclease domain complexed with diketo-acid ligands.
IUCrJ, 5, 2018
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2V6I
 | | Kokobera Virus Helicase | | Descriptor: | PYROPHOSPHATE 2-, RNA HELICASE | | Authors: | Speroni, S, De Colibus, L, Coutard, B, Canard, B, Mattevi, A. | | Deposit date: | 2007-07-18 | | Release date: | 2008-03-25 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure and Biochemical Analysis of Kokobera Virus Helicase
Proteins: Struct., Funct., Bioinf., 70, 2008
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5IQ5
 | | NMR solution structure of Mayaro virus macro domain | | Descriptor: | Macro domain | | Authors: | Melekis, E, Tsika, A.C, Bentrop, D, Papageorgiou, N, Coutard, B, Spyroulias, G.A. | | Deposit date: | 2016-03-10 | | Release date: | 2017-12-20 | | Last modified: | 2024-06-19 | | Method: | SOLUTION NMR | | Cite: | Deciphering the Nucleotide and RNA Binding Selectivity of the Mayaro Virus Macro Domain.
J.Mol.Biol., 431, 2019
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5ISN
 | | NMR solution structure of macro domain from Venezuelan equine encephalitis virus | | Descriptor: | Non-structural polyprotein | | Authors: | Makrynitsa, G.I, Ntonti, D, Marousis, K.D, Tsika, A.C, Papageorgiou, N, Coutard, B, Bentrop, D, Spyroulias, G.A. | | Deposit date: | 2016-03-15 | | Release date: | 2017-11-29 | | Last modified: | 2024-06-19 | | Method: | SOLUTION NMR | | Cite: | Conformational plasticity of the VEEV macro domain is important for binding of ADP-ribose.
J.Struct.Biol., 206, 2019
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8RCQ
 | | Structural flexibility of Nucleoprotein of the Toscana virus in the presence of a nanobody. | | Descriptor: | Nucleoprotein, VHH | | Authors: | Papageorgiou, N, Ferron, F, Coutard, B, Lichiere, J, Baklouti, A. | | Deposit date: | 2023-12-06 | | Release date: | 2024-01-31 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.8 Å) | | Cite: | Structural flexibility of Toscana virus nucleoprotein in the presence of a single-chain camelid antibody.
Acta Crystallogr D Struct Biol, 80, 2024
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6T3W
 | | Coxsackie B3 2C protein in complex with S-Fluoxetine | | Descriptor: | (3S)-N-methyl-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, 2C protein, SODIUM ION, ... | | Authors: | El Kazzi, P, Papageorgiou, N, Ferron, F.P, Bauer, L, van Kuppeveld, F, Coutard, B. | | Deposit date: | 2019-10-11 | | Release date: | 2020-11-18 | | Last modified: | 2024-06-19 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Fluoxetine targets an allosteric site in the enterovirus 2C AAA+ ATPase and stabilizes a ring-shaped hexameric complex.
Sci Adv, 8, 2022
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6T2A
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6T6L
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9EXA
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8PYW
 | | Crystal structure of the human Nucleoside-diphosphate kinase B domain bound to compound diphosphate form of AT-9052-Sp. | | Descriptor: | GLYCEROL, Nucleoside diphosphate kinase B, [[(2R,3R,4R,5R)-5-(2-azanyl-6-oxidanylidene-1H-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methoxy-sulfanyl-phosphoryl] dihydrogen phosphate | | Authors: | Feracci, M, Chazot, A. | | Deposit date: | 2023-07-26 | | Release date: | 2023-12-27 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.553 Å) | | Cite: | An exonuclease-resistant chain-terminating nucleotide analogue targeting the SARS-CoV-2 replicase complex.
Nucleic Acids Res., 52, 2024
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4NZ0
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4NYZ
 | | The EMCV 3Dpol structure with altered motif A conformation at 2.15A resolution | | Descriptor: | GLUTAMINE, GLYCEROL, Genome polyprotein, ... | | Authors: | Vives-adrian, L, Lujan, C, Ferrer-orta, C, Verdaguer, N. | | Deposit date: | 2013-12-11 | | Release date: | 2014-03-19 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | The crystal structure of a cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site
J.Virol., 88, 2014
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4Y2A
 | | Crystal Structure of Coxsackie Virus B3 3D polymerase in complex with GPC-N114 inhibitor | | Descriptor: | 2,2'-[(4-chlorobenzene-1,2-diyl)bis(oxy)]bis(5-nitrobenzonitrile), 3D polymerase, GLYCEROL, ... | | Authors: | Vives-Adrian, L, Ferrer-Orta, C, Verdaguer, N. | | Deposit date: | 2015-02-09 | | Release date: | 2015-04-01 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family.
Plos Pathog., 11, 2015
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4Y34
 | | Crystal Structure of Coxsackievirus B3 3D polymerase in complex with GPC-N143 | | Descriptor: | 2,2'-[(4-fluorobenzene-1,2-diyl)bis(oxy)]bis(5-nitrobenzonitrile), 3D polymerase, GLYCEROL, ... | | Authors: | Vives-Adrian, L, Ferrer-Orta, C, Cerdaguer, N. | | Deposit date: | 2015-02-10 | | Release date: | 2015-04-01 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family.
Plos Pathog., 11, 2015
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