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8V9J
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BU of 8v9j by Molmil
Cryo-EM structure of the Mycobacterium smegmatis 70S ribosome in complex with hibernation factor Msmeg1130 (Balon) (Structure 4)
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S14, ...
Authors:Rybak, M.Y, Helena-Bueno, K, Hill, C.H, Melnikov, S.V, Gagnon, M.G.
Deposit date:2023-12-08
Release date:2024-02-07
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:A new family of bacterial ribosome hibernation factors.
Nature, 626, 2024
1ANR
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BU of 1anr by Molmil
CIS-ACTING RNA REGULATORY ELEMENT (HIV-1 TAR), NMR, 20 STRUCTURES
Descriptor: RNA REGULATORY ELEMENT TAR
Authors:Aboul-Ela, F, Varani, G, Karn, J.
Deposit date:1996-07-06
Release date:1997-01-11
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:Structure of HIV-1 TAR RNA in the absence of ligands reveals a novel conformation of the trinucleotide bulge.
Nucleic Acids Res., 24, 1996
5YZ0
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BU of 5yz0 by Molmil
Cryo-EM Structure of human ATR-ATRIP complex
Descriptor: ATR-interacting protein, Serine/threonine-protein kinase ATR
Authors:Rao, Q, Liu, M, Tian, Y, Wu, Z, Wang, H, Wang, J, Xu, Y.
Deposit date:2017-12-11
Release date:2018-01-31
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Cryo-EM structure of human ATR-ATRIP complex.
Cell Res., 28, 2018
6WPW
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BU of 6wpw by Molmil
GCGR-Gs signaling complex bound to a designed glucagon derivative
Descriptor: Glucagon derivative ZP3780, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Hilger, D, Krishna Kumar, K, Hu, H, Mathiesen, J.M, Skiniotis, G, Kobilka, B.K.
Deposit date:2020-04-28
Release date:2020-08-12
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural insights into differences in G protein activation by family A and family B GPCRs.
Science, 369, 2020
8V9K
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BU of 8v9k by Molmil
Cryo-EM structure of the Mycobacterium smegmatis 70S ribosome in complex with hibernation factor Rv2629 (Balon) (Structure 5)
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S2, ...
Authors:Rybak, M.Y, Helena-Bueno, K, Hill, C.H, Melnikov, S.V, Gagnon, M.G.
Deposit date:2023-12-08
Release date:2024-02-07
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:A new family of bacterial ribosome hibernation factors.
Nature, 626, 2024
8V9L
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BU of 8v9l by Molmil
Cryo-EM structure of the Mycobacterium smegmatis 70S ribosome in complex with hibernation factor Msmeg1130 (Balon) and MsmegEF-Tu(GDP) (Composite structure 6)
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S2, ...
Authors:Rybak, M.Y, Helena-Bueno, K, Hill, C.H, Melnikov, S.V, Gagnon, M.G.
Deposit date:2023-12-08
Release date:2024-02-07
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3 Å)
Cite:A new family of bacterial ribosome hibernation factors.
Nature, 626, 2024
6UMH
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BU of 6umh by Molmil
Crystal structure of erenumab Fab-a
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,3-PROPANDIOL, PHOSPHATE ION, ...
Authors:Mohr, C.
Deposit date:2019-10-09
Release date:2020-02-12
Last modified:2020-02-26
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Molecular Insight into Recognition of the CGRPR Complex by Migraine Prevention Therapy Aimovig (Erenumab).
Cell Rep, 30, 2020
6UMG
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BU of 6umg by Molmil
Crystal structure of erenumab Fab bound to the extracellular domain of CGRP receptor
Descriptor: Calcitonin gene-related peptide type 1 receptor, Receptor activity-modifying protein 1, erenumab Fab heavy chain, ...
Authors:Mohr, C.
Deposit date:2019-10-09
Release date:2020-02-12
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular Insight into Recognition of the CGRPR Complex by Migraine Prevention Therapy Aimovig (Erenumab).
Cell Rep, 30, 2020
6UMJ
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BU of 6umj by Molmil
Crystal structure of erenumab Fab-c
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,3-BUTANEDIOL, erenumab Fab heavy chain, ...
Authors:Mohr, C.
Deposit date:2019-10-09
Release date:2020-02-12
Last modified:2020-02-26
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular Insight into Recognition of the CGRPR Complex by Migraine Prevention Therapy Aimovig (Erenumab).
Cell Rep, 30, 2020
5V3Z
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BU of 5v3z by Molmil
Crystal Structure of the D1607N mutant form of Thioesterase domain of Mtb Pks13
Descriptor: PENTAETHYLENE GLYCOL, Polyketide synthase Pks13 (Termination polyketide synthase), SULFATE ION
Authors:Aggarwal, A, Sacchettini, J.C.
Deposit date:2017-03-08
Release date:2017-07-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.881 Å)
Cite:Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
Cell, 170, 2017
6UMI
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BU of 6umi by Molmil
Crystal structure of erenumab Fab-b
Descriptor: erenumab Fab heavy chain, IgG1, erenumab Fab light chain
Authors:Mohr, C.
Deposit date:2019-10-09
Release date:2020-02-12
Last modified:2020-02-26
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Molecular Insight into Recognition of the CGRPR Complex by Migraine Prevention Therapy Aimovig (Erenumab).
Cell Rep, 30, 2020
5UOS
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BU of 5uos by Molmil
Crystal Structure of CblC (MMACHC) (1-238), a human B12 processing enzyme, complexed with an Antivitamin B12
Descriptor: 1-ethynyl-2,4-difluorobenzene, 2-PHENYLAMINO-ETHANESULFONIC ACID, COBALAMIN, ...
Authors:Shanmuganathan, A, Karasik, A, Ruetz, M, Banerjee, R, Krautler, B, Koutmos, M.
Deposit date:2017-02-01
Release date:2017-06-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Antivitamin B12 Inhibition of the Human B12 -Processing Enzyme CblC: Crystal Structure of an Inactive Ternary Complex with Glutathione as the Cosubstrate.
Angew. Chem. Int. Ed. Engl., 56, 2017
6MCV
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BU of 6mcv by Molmil
Crystal Structure of Holo Retinal-Bound Domain-Swapped Dimer of Wild Type Human Cellular Retinol Binding Protein II
Descriptor: RETINAL, Retinol-binding protein 2
Authors:Ghanbarpour, A, Geiger, J.
Deposit date:2018-09-02
Release date:2019-10-16
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Engineering the hCRBPII Domain-Swapped Dimer into a New Class of Protein Switches.
J.Am.Chem.Soc., 141, 2019
8SF6
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BU of 8sf6 by Molmil
Promiscuous amino acid gamma synthase from Caldicellulosiruptor hydrothermalis in closed conformation
Descriptor: 2-(2-ETHOXYETHOXY)ETHANOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ...
Authors:Buller, A.R, Zmich, A.P, Bingman, C.A.
Deposit date:2023-04-10
Release date:2023-12-27
Method:X-RAY DIFFRACTION (1.702 Å)
Cite:Multiplexed Assessment of Promiscuous Non-Canonical Amino Acid Synthase Activity in a Pyridoxal Phosphate-Dependent Protein Family.
Acs Catalysis, 13, 2023
8SF5
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BU of 8sf5 by Molmil
Promiscuous amino acid gamma synthase from Caldicellulosiruptor hydrothermalis in open conformation
Descriptor: O-acetylhomoserine/O-acetylserine sulfhydrylase
Authors:Buller, A.R, Zmich, A.P, Bingman, C.A.
Deposit date:2023-04-10
Release date:2023-12-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Multiplexed Assessment of Promiscuous Non-Canonical Amino Acid Synthase Activity in a Pyridoxal Phosphate-Dependent Protein Family.
Acs Catalysis, 13, 2023
8ELO
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BU of 8elo by Molmil
Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with antibody CC12.1 Fab and nanobody Nb-C4-225
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CC12.1 Fab heavy chain, CC12.1 Fab light chain, ...
Authors:Liu, H, Wilson, I.A.
Deposit date:2022-09-26
Release date:2023-07-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.72 Å)
Cite:Fully synthetic platform to rapidly generate tetravalent bispecific nanobody-based immunoglobulins.
Proc.Natl.Acad.Sci.USA, 120, 2023
8ELQ
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BU of 8elq by Molmil
Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with antibody CC12.1 Fab and nanobody Nb-C4-255
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CC12.1 Fab heavy chain, CC12.1 Fab light chain, ...
Authors:Liu, H, Wilson, I.A.
Deposit date:2022-09-26
Release date:2023-07-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Fully synthetic platform to rapidly generate tetravalent bispecific nanobody-based immunoglobulins.
Proc.Natl.Acad.Sci.USA, 120, 2023
8ELP
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BU of 8elp by Molmil
Crystal structure of SARS-CoV-2 spike protein receptor-binding domain in complex with antibody CC12.1 Fab and nanobody Nb-C4-240
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CC12.1 Fab heavy chain, CC12.1 Fab light chain, ...
Authors:Liu, H, Wilson, I.A.
Deposit date:2022-09-26
Release date:2023-07-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:Fully synthetic platform to rapidly generate tetravalent bispecific nanobody-based immunoglobulins.
Proc.Natl.Acad.Sci.USA, 120, 2023
5V42
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BU of 5v42 by Molmil
Crystal Structure of Mtb Pks13 Thioesterase domain in complex with inhibitor TAM3
Descriptor: Polyketide synthase Pks13 (Termination polyketide synthase), ethyl 5-hydroxy-2-phenyl-4-(pyrrolidin-1-ylmethyl)-1-benzofuran-3-carboxylate
Authors:Aggarwal, A, Sacchettini, J.C.
Deposit date:2017-03-08
Release date:2017-07-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.987 Å)
Cite:Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
Cell, 170, 2017
5V3Y
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BU of 5v3y by Molmil
Crystal Structure of Mtb Pks13 Thioesterase domain in complex with inhibitor TAM16
Descriptor: 2-(4-hydroxyphenyl)-~{N}-methyl-5-oxidanyl-4-(piperidin-1-ylmethyl)-1-benzofuran-3-carboxamide, Polyketide synthase Pks13 (Termination polyketide synthase), SULFATE ION
Authors:Aggarwal, A, Sacchettini, J.C.
Deposit date:2017-03-08
Release date:2017-07-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
Cell, 170, 2017
6MCU
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BU of 6mcu by Molmil
Crystal structure of the holo retinal-bound domain-swapped dimer Q108K:T51D:A28H mutant of human Cellular Retinol Binding Protein II
Descriptor: GLYCEROL, RETINAL, Retinol-binding protein 2
Authors:Ghanbarpour, A, Geiger, J.
Deposit date:2018-09-02
Release date:2019-10-16
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.572 Å)
Cite:Engineering the hCRBPII Domain-Swapped Dimer into a New Class of Protein Switches.
J.Am.Chem.Soc., 141, 2019
5V40
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BU of 5v40 by Molmil
Crystal Structure of Mtb Pks13 Thioesterase domain in complex with inhibitor TAM6
Descriptor: Polyketide synthase Pks13 (Termination polyketide synthase), ethyl 4-[(dimethylamino)methyl]-5-hydroxy-2-phenyl-1-benzofuran-3-carboxylate
Authors:Aggarwal, A, Sacchettini, J.C.
Deposit date:2017-03-08
Release date:2017-07-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.991 Å)
Cite:Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
Cell, 170, 2017
6W05
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BU of 6w05 by Molmil
Crystal structure of Fab356 in complex with NPNA2 peptide from circumsporozoite protein
Descriptor: Fab356 heavy chain, Fab356 light chain, NPNA2 peptide
Authors:Pholcharee, T, Oyen, D, Wilson, I.A.
Deposit date:2020-02-29
Release date:2020-07-29
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (2.516 Å)
Cite:Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum.
Nat Commun, 12, 2021
5IV5
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BU of 5iv5 by Molmil
Cryo-electron microscopy structure of the hexagonal pre-attachment T4 baseplate-tail tube complex
Descriptor: Baseplate hub protein gp27, Baseplate tail-tube protein gp48, Baseplate tail-tube protein gp54, ...
Authors:Taylor, N.M.I, Guerrero-Ferreira, R.C, Goldie, K.N, Stahlberg, H, Leiman, P.G.
Deposit date:2016-03-19
Release date:2016-05-18
Last modified:2018-02-07
Method:ELECTRON MICROSCOPY (4.11 Å)
Cite:Structure of the T4 baseplate and its function in triggering sheath contraction.
Nature, 533, 2016
6W00
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BU of 6w00 by Molmil
Crystal structure of Fab239 in complex with NPNA2 peptide from circumsporozoite protein
Descriptor: Fab239 heavy chain, Fab239 light chain, Immunoglobulin G-binding protein G, ...
Authors:Pholcharee, T, Oyen, D, Wilson, I.A.
Deposit date:2020-02-28
Release date:2020-07-29
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.853 Å)
Cite:Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum.
Nat Commun, 12, 2021

221716

數據於2024-06-26公開中

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