6FI4
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![BU of 6fi4 by Molmil](/molmil-images/mine/6fi4) | Crystal structure of C-terminal modified Tau peptide-hybrid 3.2e with 14-3-3sigma | Descriptor: | (2~{S})-2-(diphenylmethyl)pyrrolidine, 14-3-3 protein sigma, CALCIUM ION, ... | Authors: | Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G. | Deposit date: | 2018-01-17 | Release date: | 2018-05-16 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes. ACS Chem Neurosci, 9, 2018
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6FAV
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![BU of 6fav by Molmil](/molmil-images/mine/6fav) | Crystal structure of C-terminal modified Tau peptide-hybrid 4.2f-I with 14-3-3sigma | Descriptor: | (2~{R})-2-[(~{R})-(3-methoxyphenyl)-phenyl-methyl]pyrrolidine, 14-3-3 protein sigma, ACE-ARG-THR-PRO-SEP-LEU-PRO-GLY, ... | Authors: | Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G. | Deposit date: | 2017-12-18 | Release date: | 2018-05-16 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes. ACS Chem Neurosci, 9, 2018
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6FBY
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![BU of 6fby by Molmil](/molmil-images/mine/6fby) | Crystal structure of C-terminal modified Tau peptide-hybrid 4.2b with 14-3-3sigma | Descriptor: | (2~{R})-2-[(~{S})-(3-methylphenyl)-phenyl-methyl]pyrrolidine, 14-3-3 protein sigma, ACE-ARG-THR-PRO-SEP-LEU-PRO-GLY, ... | Authors: | Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G. | Deposit date: | 2017-12-20 | Release date: | 2018-05-16 | Last modified: | 2019-02-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes. ACS Chem Neurosci, 9, 2018
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6FI5
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![BU of 6fi5 by Molmil](/molmil-images/mine/6fi5) | Crystal structure of C-terminal modified Tau peptide-hybrid 3.2d with 14-3-3sigma | Descriptor: | (2~{S})-2-(diphenylmethyl)pyrrolidine, 14-3-3 protein sigma, CHLORIDE ION, ... | Authors: | Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G. | Deposit date: | 2018-01-17 | Release date: | 2018-05-16 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes. ACS Chem Neurosci, 9, 2018
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6FAW
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![BU of 6faw by Molmil](/molmil-images/mine/6faw) | Crystal structure of C-terminal modified Tau peptide-hybrid 4.2c-I with 14-3-3sigma | Descriptor: | (2~{R})-2-[(~{R})-[2-(2-methoxyethoxy)phenyl]-phenyl-methyl]pyrrolidine, 14-3-3 protein sigma, ACE-ARG-THR-PRO-SEP-LEU-PRO-GLY, ... | Authors: | Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G. | Deposit date: | 2017-12-18 | Release date: | 2018-05-16 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes. ACS Chem Neurosci, 9, 2018
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6FBW
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![BU of 6fbw by Molmil](/molmil-images/mine/6fbw) | Crystal structure of C-terminal modified Tau peptide-hybrid 4.2f-II with 14-3-3sigma | Descriptor: | (2~{R})-2-[(~{S})-(3-methoxyphenyl)-phenyl-methyl]pyrrolidine, 14-3-3 protein sigma, ARG-THR-PRO-SEP-LEU-PRO-GLY, ... | Authors: | Andrei, S.A, Meijer, F.A, Ottmann, C, Milroy, L.G. | Deposit date: | 2017-12-20 | Release date: | 2018-05-16 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Inhibition of 14-3-3/Tau by Hybrid Small-Molecule Peptides Operating via Two Different Binding Modes. ACS Chem Neurosci, 9, 2018
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5L9V
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![BU of 5l9v by Molmil](/molmil-images/mine/5l9v) | |
5LAS
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![BU of 5las by Molmil](/molmil-images/mine/5las) | |
5LB6
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![BU of 5lb6 by Molmil](/molmil-images/mine/5lb6) | |
5LBE
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![BU of 5lbe by Molmil](/molmil-images/mine/5lbe) | |
5LBC
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![BU of 5lbc by Molmil](/molmil-images/mine/5lbc) | |
5LBB
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![BU of 5lbb by Molmil](/molmil-images/mine/5lbb) | |
5L9B
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![BU of 5l9b by Molmil](/molmil-images/mine/5l9b) | |
5LA9
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![BU of 5la9 by Molmil](/molmil-images/mine/5la9) | |
5L9R
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![BU of 5l9r by Molmil](/molmil-images/mine/5l9r) | |
5LBF
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![BU of 5lbf by Molmil](/molmil-images/mine/5lbf) | |
5LAT
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![BU of 5lat by Molmil](/molmil-images/mine/5lat) | |
6YW1
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![BU of 6yw1 by Molmil](/molmil-images/mine/6yw1) | |
6YW3
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![BU of 6yw3 by Molmil](/molmil-images/mine/6yw3) | |
6YW4
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![BU of 6yw4 by Molmil](/molmil-images/mine/6yw4) | |
6YW2
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![BU of 6yw2 by Molmil](/molmil-images/mine/6yw2) | |
6QHL
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![BU of 6qhl by Molmil](/molmil-images/mine/6qhl) | 14-3-3 sigma with RelA/p65 binding site pS45 | Descriptor: | 14-3-3 protein sigma, GLYCEROL, Transcription factor p65 | Authors: | Wolter, M, Ottmann, C. | Deposit date: | 2019-01-16 | Release date: | 2020-05-13 | Last modified: | 2020-12-30 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products. J.Am.Chem.Soc., 142, 2020
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6RK8
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![BU of 6rk8 by Molmil](/molmil-images/mine/6rk8) | Fragment AZ-014 binding at the p53pT387/14-3-3 sigma interface | Descriptor: | 14-3-3 protein sigma, 7-(3-azanyl-4-methyl-pyrazol-1-yl)-1-benzothiophene-2-carboximidamide, CHLORIDE ION, ... | Authors: | Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Patel, J, Castaldi, P, Ottmann, C. | Deposit date: | 2019-04-30 | Release date: | 2020-06-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.602 Å) | Cite: | Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
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6RL3
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![BU of 6rl3 by Molmil](/molmil-images/mine/6rl3) | Fragment AZ-003 binding at the p53pT387/14-3-3 sigma interface | Descriptor: | 14-3-3 protein sigma, 5-azanyl-4-phenyl-thiophene-2-carboximidamide, CHLORIDE ION, ... | Authors: | Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Patel, J, Castaldi, P, Ottmann, C. | Deposit date: | 2019-05-01 | Release date: | 2020-06-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
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6RL6
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![BU of 6rl6 by Molmil](/molmil-images/mine/6rl6) | Fragment AZ-024 binding at the p53pT387/14-3-3 sigma interface | Descriptor: | 14-3-3 protein sigma, CHLORIDE ION, Cellular tumor antigen p53, ... | Authors: | Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Patel, J, Castaldi, P, Ottmann, C. | Deposit date: | 2019-05-01 | Release date: | 2020-06-17 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
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