3OY8
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3OYW
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2NMO
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2NMN
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6BFZ
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![BU of 6bfz by Molmil](/molmil-images/mine/6bfz) | Crystal structure of enolase from E. coli with a mixture of apo form, substrate, and product form | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-PHOSPHOGLYCERIC ACID, Enolase, ... | Authors: | Erlandsen, H, Wright, D, Krucinska, J. | Deposit date: | 2017-10-27 | Release date: | 2018-10-31 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | Structural and Functional Studies of Bacterial Enolase, a Potential Target against Gram-Negative Pathogens. Biochemistry, 58, 2019
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6BFY
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![BU of 6bfy by Molmil](/molmil-images/mine/6bfy) | Crystal structure of enolase from Escherichia coli with bound 2-phosphoglycerate substrate | Descriptor: | 2-PHOSPHOGLYCERIC ACID, Enolase, GLYCEROL, ... | Authors: | Erlandsen, H, Wright, D, Krucinska, J. | Deposit date: | 2017-10-27 | Release date: | 2018-10-31 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Structural and Functional Studies of Bacterial Enolase, a Potential Target against Gram-Negative Pathogens. Biochemistry, 58, 2019
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1PAH
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6NPF
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![BU of 6npf by Molmil](/molmil-images/mine/6npf) | Structure of E.coli enolase in complex with an analog of the natural product SF-2312 metabolite. | Descriptor: | Enolase, GLYCEROL, L(+)-TARTARIC ACID, ... | Authors: | Erlandsen, H, Krucinska, J, Lombardo, M, Wright, D. | Deposit date: | 2019-01-17 | Release date: | 2019-11-27 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | Functional and structural basis of E. coli enolase inhibition by SF2312: a mimic of the carbanion intermediate. Sci Rep, 9, 2019
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6D3L
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![BU of 6d3l by Molmil](/molmil-images/mine/6d3l) | Crystal structure of unphosphorylated human PKR | Descriptor: | Interferon-induced, double-stranded RNA-activated protein kinase | Authors: | Erlandsen, H, Mayo, C, Robinson, V.L, Cole, J.L. | Deposit date: | 2018-04-16 | Release date: | 2019-07-10 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural Basis of Protein Kinase R Autophosphorylation. Biochemistry, 58, 2019
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6D3Q
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![BU of 6d3q by Molmil](/molmil-images/mine/6d3q) | Crystal structure of Escherichia coli enolase complexed with a natural inhibitor SF2312. | Descriptor: | Enolase, GLYCEROL, MAGNESIUM ION, ... | Authors: | Erlandsen, H, Krucinska, J, Hazeen, A, Wright, D. | Deposit date: | 2018-04-16 | Release date: | 2019-11-27 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.24 Å) | Cite: | Functional and structural basis of E. coli enolase inhibition by SF2312: a mimic of the carbanion intermediate. Sci Rep, 9, 2019
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6D3K
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![BU of 6d3k by Molmil](/molmil-images/mine/6d3k) | Crystal structure of unphosphorylated human PKR kinase domain in complex with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Interferon-induced, double-stranded RNA-activated protein kinase, ... | Authors: | Erlandsen, H, Mayo, C.B, Robinson, V.L, Cole, J.L. | Deposit date: | 2018-04-16 | Release date: | 2019-07-10 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural Basis of Protein Kinase R Autophosphorylation. Biochemistry, 58, 2019
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5VWG
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3T1M
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3T2T
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3T1L
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4KAP
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![BU of 4kap by Molmil](/molmil-images/mine/4kap) | The Binding of Benzoarylsulfonamide Ligands to Human Carbonic Anhydrase is Insensitive to Formal Fluorination of the Ligand | Descriptor: | 4,5,6,7-tetrafluoro-1,3-benzothiazole-2-sulfonamide, Carbonic anhydrase 2, ZINC ION | Authors: | Lange, H, Lockett, M.R, Breiten, B, Heroux, A, Sherman, W, Rappoport, D, Yau, P.O, Snyder, P.W, Whitesides, G.M. | Deposit date: | 2013-04-22 | Release date: | 2013-07-10 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | The Binding of Benzoarylsulfonamide Ligands to Human Carbonic Anhydrase is Insensitive to Formal Fluorination of the Ligand. Angew.Chem.Int.Ed.Engl., 52, 2013
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1DVI
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![BU of 1dvi by Molmil](/molmil-images/mine/1dvi) | CALPAIN DOMAIN VI WITH CALCIUM BOUND | Descriptor: | CALCIUM ION, CALPAIN | Authors: | Cygler, M, Blanchard, H, Grochulski, P. | Deposit date: | 1997-05-15 | Release date: | 1998-05-27 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of a calpain Ca(2+)-binding domain reveals a novel EF-hand and Ca(2+)-induced conformational changes. Nat.Struct.Biol., 4, 1997
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3SIS
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3SIT
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1AJ5
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![BU of 1aj5 by Molmil](/molmil-images/mine/1aj5) | CALPAIN DOMAIN VI APO | Descriptor: | CALPAIN | Authors: | Cygler, M, Grochulski, P, Blanchard, H. | Deposit date: | 1997-05-15 | Release date: | 1998-05-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of a calpain Ca(2+)-binding domain reveals a novel EF-hand and Ca(2+)-induced conformational changes. Nat.Struct.Biol., 4, 1997
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1MLW
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![BU of 1mlw by Molmil](/molmil-images/mine/1mlw) | Crystal structure of human tryptophan hydroxylase with bound 7,8-dihydro-L-biopterin cofactor and Fe(III) | Descriptor: | 7,8-DIHYDROBIOPTERIN, FE (III) ION, Tryptophan 5-monooxygenase | Authors: | Wang, L, Erlandsen, H, Haavik, J, Knappskog, P.M, Stevens, R.C. | Deposit date: | 2002-08-31 | Release date: | 2002-12-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin Biochemistry, 41, 2002
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5E89
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![BU of 5e89 by Molmil](/molmil-images/mine/5e89) | Crystal structure of Human galectin-3 CRD in complex with 3-fluophenyl-1,2,3-triazolyl thiodigalactoside inhibitor | Descriptor: | 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-3-[4-(3-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-beta-D-galactopyranoside, CHLORIDE ION, Galectin-3 | Authors: | Collins, P.M, Blanchard, H. | Deposit date: | 2015-10-13 | Release date: | 2016-08-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition. Chembiochem, 17, 2016
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5E8A
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![BU of 5e8a by Molmil](/molmil-images/mine/5e8a) | Crystal structure of Human galectin-3 CRD in complex with 4-fluophenyl-1,2,3-triazolyl thiodigalactoside inhibitor | Descriptor: | 3-deoxy-3-[4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl]-beta-D-galactopyranosyl 3-deoxy-3-[4-(4-fluorophenyl)-1H-1,2,3-triazol-1-yl]-1-thio-beta-D-galactopyranoside, CHLORIDE ION, Galectin-3 | Authors: | Collins, P.M, Blanchard, H. | Deposit date: | 2015-10-13 | Release date: | 2016-08-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Galectin-3-Binding Glycomimetics that Strongly Reduce Bleomycin-Induced Lung Fibrosis and Modulate Intracellular Glycan Recognition. Chembiochem, 17, 2016
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5DUV
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![BU of 5duv by Molmil](/molmil-images/mine/5duv) | Crystal structure of the human galectin-4 N-terminal carbohydrate recognition domain in complex with lactose | Descriptor: | ACETATE ION, CALCIUM ION, Galectin-4, ... | Authors: | Bum-Erdene, K, Blanchard, H. | Deposit date: | 2015-09-21 | Release date: | 2016-02-17 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural characterisation of human galectin-4 N-terminal carbohydrate recognition domain in complex with glycerol, lactose, 3'-sulfo-lactose, and 2'-fucosyllactose. Sci Rep, 6, 2016
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4O2B
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![BU of 4o2b by Molmil](/molmil-images/mine/4o2b) | Tubulin-Colchicine complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | Authors: | Prota, A.E, Franck, D, Bachmann, F, Bargsten, K, Buey, R.M, Pohlmann, J, Reinelt, S, Lane, H, Steinmetz, M.O. | Deposit date: | 2013-12-17 | Release date: | 2014-03-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The Novel Microtubule-Destabilizing Drug BAL27862 Binds to the Colchicine Site of Tubulin with Distinct Effects on Microtubule Organization. J.Mol.Biol., 426, 2014
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