2XYR
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![BU of 2xyr by Molmil](/molmil-images/mine/2xyr) | Crystal structure of the nsp16 nsp10 SARS coronavirus complex | Descriptor: | CHLORIDE ION, MAGNESIUM ION, NON-STRUCTURAL PROTEIN 10, ... | Authors: | Decroly, E, Debarnot, C, Ferron, F, Bouvet, M, Coutard, B, Imbert, I, Gluais, L, Papageorgiou, N, Ortiz-Lombardia, M, Lescar, J, Canard, B. | Deposit date: | 2010-11-18 | Release date: | 2011-10-26 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal Structure and Functional Analysis of the Sars-Coronavirus RNA CAP 2'-O-Methyltransferase Nsp10/Nsp16 Complex. Plos Pathog., 7, 2011
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2XYQ
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![BU of 2xyq by Molmil](/molmil-images/mine/2xyq) | Crystal structure of the nsp16 nsp10 SARS coronavirus complex | Descriptor: | CHLORIDE ION, MAGNESIUM ION, NON-STRUCTURAL PROTEIN 10, ... | Authors: | Decroly, E, Debarnot, C, Ferron, F, Bouvet, M, Coutard, B, Imbert, I, Gluais, L, Papageorgiou, N, Ortiz-Lombardia, M, Lescar, J, Canard, B. | Deposit date: | 2010-11-18 | Release date: | 2011-10-19 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structure and Functional Analysis of the Sars-Coronavirus RNA CAP 2'-O-Methyltransferase Nsp10/Nsp16 Complex. Plos Pathog., 7, 2011
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4CP5
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![BU of 4cp5 by Molmil](/molmil-images/mine/4cp5) | ndpK in complex with (Rp)-SPMPApp | Descriptor: | NUCLEOSIDE DIPHOSPHATE KINASE, CYTOSOLIC, [[(2R)-1-(6-aminopurin-9-yl)propan-2-yl]oxymethyl-sulfanyl-phosphoryl] phosphono hydrogen phosphate | Authors: | Priet, S, Ferron, F, Alvarez, K, Verron, M, Canard, B. | Deposit date: | 2014-01-31 | Release date: | 2015-02-11 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | Enzymatic Synthesis of Acyclic Nucleoside Thiophosphonate Diphosphates: Effect of the Alpha-Phosphorus Configuration on HIV-1 RT Activity. Antiviral Res., 117, 2015
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4C6A
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![BU of 4c6a by Molmil](/molmil-images/mine/4c6a) | High Resolution Structure of the Nucleoside diphosphate kinase | Descriptor: | DI(HYDROXYETHYL)ETHER, NUCLEOSIDE DIPHOSPHATE KINASE, CYTOSOLIC | Authors: | Priet, S, Ferron, F, Alvarez, K, Verron, M, Canard, B. | Deposit date: | 2013-09-18 | Release date: | 2013-11-20 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Enzymatic Synthesis of Acyclic Nucleoside Thiophosphonate Diphosphates: Effect of the Alpha-Phosphorus Configuration on HIV-1 RT Activity. Antiviral Res., 117, 2015
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2V6I
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![BU of 2v6i by Molmil](/molmil-images/mine/2v6i) | Kokobera Virus Helicase | Descriptor: | PYROPHOSPHATE 2-, RNA HELICASE | Authors: | Speroni, S, De Colibus, L, Coutard, B, Canard, B, Mattevi, A. | Deposit date: | 2007-07-18 | Release date: | 2008-03-25 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure and Biochemical Analysis of Kokobera Virus Helicase Proteins: Struct., Funct., Bioinf., 70, 2008
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2V6J
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![BU of 2v6j by Molmil](/molmil-images/mine/2v6j) | Kokobera Virus Helicase: Mutant Met47Thr | Descriptor: | RNA HELICASE | Authors: | Speroni, S, De Colibus, L, Coutard, B, Canard, B, Mattevi, A. | Deposit date: | 2007-07-18 | Release date: | 2008-03-25 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure and Biochemical Analysis of Kokobera Virus Helicase Proteins: Struct., Funct., Bioinf., 70, 2008
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2W5E
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![BU of 2w5e by Molmil](/molmil-images/mine/2w5e) | Structural and biochemical analysis of human pathogenic astrovirus serine protease at 2.0 Angstrom resolution | Descriptor: | CADMIUM ION, CHLORIDE ION, PUTATIVE SERINE PROTEASE | Authors: | Speroni, S, Rohayem, J, Nenci, S, Bonivento, D, Robel, I, Barthel, J, Coutard, B, Canard, B, Mattevi, A. | Deposit date: | 2008-12-10 | Release date: | 2009-03-10 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural and Biochemical Analysis of Human Pathogenic Astrovirus Serine Protease at 2.0 A Resolution. J.Mol.Biol., 387, 2009
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3CDU
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![BU of 3cdu by Molmil](/molmil-images/mine/3cdu) | Crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase (3Dpol) in complex with a pyrophosphate | Descriptor: | ACETATE ION, CHLORIDE ION, GLYCEROL, ... | Authors: | Gruez, A, Selisko, B, Roberts, M, Bricogne, G, Bussetta, C, Canard, B. | Deposit date: | 2008-02-27 | Release date: | 2008-07-22 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on Picornaviridae polymerases J.Virol., 82, 2008
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3CDW
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![BU of 3cdw by Molmil](/molmil-images/mine/3cdw) | Crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase (3Dpol) in complex with protein primer VPg and a pyrophosphate | Descriptor: | ACETATE ION, CHLORIDE ION, GLYCEROL, ... | Authors: | Gruez, A, Selisko, B, Roberts, M, Bricogne, G, Bussetta, C, Canard, B. | Deposit date: | 2008-02-27 | Release date: | 2008-07-22 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on Picornaviridae polymerases J.Virol., 82, 2008
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8PTS
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![BU of 8pts by Molmil](/molmil-images/mine/8pts) | human GUK1 in complex with compound AT8001 | Descriptor: | GLYCEROL, Guanylate kinase, [(2~{R},3~{R},4~{R},5~{R})-5-(2-azanyl-6-oxidanylidene-1~{H}-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methyl dihydrogen phosphate | Authors: | Zimberger, C, Canard, B, Ferron, F. | Deposit date: | 2023-07-14 | Release date: | 2024-07-24 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Structural and functional basis for metabolic activation of the antiviral drug Bemnifosbuvir To Be Published
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4TU0
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![BU of 4tu0 by Molmil](/molmil-images/mine/4tu0) | CRYSTAL STRUCTURE OF CHIKUNGUNYA VIRUS NSP3 MACRO DOMAIN IN COMPLEX WITH A 2'-5' OLIGOADENYLATE TRIMER | Descriptor: | 2'-5' OLIGOADENYLATE TRIMER, DI(HYDROXYETHYL)ETHER, Non-structural polyprotein 3 | Authors: | Morin, B, Ferron, f.p, Malet, h, Coutard, b, Canard, b. | Deposit date: | 2014-06-23 | Release date: | 2014-07-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | CRYSTAL STRUCTURE OF CHIKUNGUNYA VIRUS NSP3 MACRO DOMAIN IN COMPLEX WITH A 2'-5' OLIGOADENYLATE TRIMER TO BE PUBLISHED
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3OUO
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![BU of 3ouo by Molmil](/molmil-images/mine/3ouo) | Structure of the Nucleoprotein from Rift Valley Fever Virus | Descriptor: | NITRITE ION, Nucleoprotein | Authors: | Ferron, F, Danek, E.I, Li, Z, Luo, D, Wong, Y.H, Coutard, B, Lantez, V, Charrel, R, Canard, B, Walz, T, Lescar, J. | Deposit date: | 2010-09-15 | Release date: | 2011-05-25 | Last modified: | 2013-08-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes Plos Pathog., 7, 2011
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3Q3Y
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![BU of 3q3y by Molmil](/molmil-images/mine/3q3y) | Complex structure of HEVB EV93 main protease 3C with Compound 1 (AG7404) | Descriptor: | 1,2-ETHANEDIOL, AMMONIUM ION, HEVB EV93 3C protease, ... | Authors: | Costenaro, L, Kaczmarska, Z, Arnan, C, Sola, M, Coutard, B, Norder, H, Canard, B, Coll, M. | Deposit date: | 2010-12-22 | Release date: | 2011-09-07 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | Structural Basis for Antiviral Inhibition of the Main Protease, 3C, from Human Enterovirus 93. J.Virol., 85, 2011
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3OV9
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![BU of 3ov9 by Molmil](/molmil-images/mine/3ov9) | Structure of the Nucleoprotein from Rift Valley Fever Virus | Descriptor: | NITRITE ION, Nucleoprotein, SODIUM ION | Authors: | Ferron, F, Danek, E.I, Li, Z, Luo, D, Wong, Y.H, Coutard, B, Lantez, V, Charrel, R, Canard, B, Walz, T, Lescar, J. | Deposit date: | 2010-09-16 | Release date: | 2011-05-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | The hexamer structure of Rift Valley fever virus nucleoprotein suggests a mechanism for its assembly into ribonucleoprotein complexes Plos Pathog., 7, 2011
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3Q3X
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![BU of 3q3x by Molmil](/molmil-images/mine/3q3x) | Crystal structure of the main protease (3C) from human enterovirus B EV93 | Descriptor: | GLYCEROL, HEVB EV93 3C protease, MAGNESIUM ION | Authors: | Costenaro, L, Sola, M, Coutard, B, Norder, H, Canard, B, Coll, M. | Deposit date: | 2010-12-22 | Release date: | 2011-09-07 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural Basis for Antiviral Inhibition of the Main Protease, 3C, from Human Enterovirus 93. J.Virol., 85, 2011
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3RUO
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![BU of 3ruo by Molmil](/molmil-images/mine/3ruo) | Complex structure of HevB EV93 main protease 3C with Rupintrivir (AG7088) | Descriptor: | 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER, CHLORIDE ION, HEVB EV93 3C PROTEASE, ... | Authors: | Kaczmarska, Z, Janowski, R, Costenaro, L, Coutard, B, Norder, H, Canard, B, Coll, M. | Deposit date: | 2011-05-05 | Release date: | 2011-09-07 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural Basis for Antiviral Inhibition of the Main Protease, 3C, from Human Enterovirus 93. J.Virol., 85, 2011
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3GQE
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![BU of 3gqe by Molmil](/molmil-images/mine/3gqe) | Crystal structure of macro domain of Venezuelan Equine Encephalitis virus | Descriptor: | BICINE, Non-structural protein 3 | Authors: | Jamal, S, Malet, H, Coutard, B, Canard, B. | Deposit date: | 2009-03-24 | Release date: | 2009-07-21 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket J.Virol., 83, 2009
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3GQO
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![BU of 3gqo by Molmil](/molmil-images/mine/3gqo) | Crystal structure of macro domain of Venezuelan Equine Encephalitis virus in complex with ADP-ribose | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, Non-structural protein 3 | Authors: | Malet, H, Jamal, S, Coutard, B, Ferron, F, Canard, B. | Deposit date: | 2009-03-24 | Release date: | 2009-07-21 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket J.Virol., 83, 2009
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3GPQ
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![BU of 3gpq by Molmil](/molmil-images/mine/3gpq) | Crystal structure of macro domain of Chikungunya virus in complex with RNA | Descriptor: | Non-structural protein 3, RNA (5'-R(*AP*AP*A)-3') | Authors: | Malet, H, Jamal, S, Coutard, B, Canard, B. | Deposit date: | 2009-03-23 | Release date: | 2009-07-21 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket J.Virol., 83, 2009
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4UD1
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![BU of 4ud1 by Molmil](/molmil-images/mine/4ud1) | Structure of the N Terminal domain of the MERS CoV nucleocapsid | Descriptor: | AMMONIUM ION, GLYCEROL, IMIDAZOLE, ... | Authors: | Papageorgiou, N, Lichiere, J, Ferron, F, Canard, B, Coutard, B. | Deposit date: | 2014-12-05 | Release date: | 2015-12-02 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Structural Characterization of the N-Terminal Part of the Mers-Cov Nucleocapsid by X-Ray Diffraction and Small-Angle X-Ray Scattering Acta Crystallogr.,Sect.D, 72, 2016
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3GPO
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![BU of 3gpo by Molmil](/molmil-images/mine/3gpo) | Crystal structure of macro domain of Chikungunya virus in complex with ADP-ribose | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, Non-structural protein 3 | Authors: | Malet, H, Jamal, S, Coutard, B, Canard, B. | Deposit date: | 2009-03-23 | Release date: | 2009-07-21 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The crystal structures of Chikungunya and Venezuelan equine encephalitis virus nsP3 macro domains define a conserved adenosine binding pocket J.Virol., 83, 2009
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3GPG
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![BU of 3gpg by Molmil](/molmil-images/mine/3gpg) | |
5NFY
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![BU of 5nfy by Molmil](/molmil-images/mine/5nfy) | SARS-CoV nsp10/nsp14 dynamic complex | Descriptor: | DI(HYDROXYETHYL)ETHER, Polyprotein 1ab, ZINC ION | Authors: | Ferron, F, Gluais, L, Vonrhein, C, Bricogne, G, Canard, B, Imbert, I. | Deposit date: | 2017-03-16 | Release date: | 2018-01-10 | Last modified: | 2019-02-20 | Method: | X-RAY DIFFRACTION (3.382 Å) | Cite: | Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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5LRP
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![BU of 5lrp by Molmil](/molmil-images/mine/5lrp) | Mopeia Virus Exonuclease domain complexed with Magnesium | Descriptor: | MAGNESIUM ION, Nucleoprotein, ZINC ION | Authors: | Yekwa, E.L, Khourieh, J, Canard, B, Ferron, F. | Deposit date: | 2016-08-19 | Release date: | 2017-07-05 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.941 Å) | Cite: | Activity inhibition and crystal polymorphism induced by active-site metal swapping. Acta Crystallogr D Struct Biol, 73, 2017
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5LTS
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![BU of 5lts by Molmil](/molmil-images/mine/5lts) | Crystal structure of Lymphocytic choriomeningitis mammarenavirus endonuclease Mutant D118A | Descriptor: | CHLORIDE ION, GLYCEROL, RNA-directed RNA polymerase L, ... | Authors: | Saez-Ayala, M, Yekwa, E.L, Canard, B, Alvarez, K, Ferron, F. | Deposit date: | 2016-09-07 | Release date: | 2017-09-13 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Crystal structures ofLymphocytic choriomeningitis virusendonuclease domain complexed with diketo-acid ligands. IUCrJ, 5, 2018
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