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3Q3Y

Complex structure of HEVB EV93 main protease 3C with Compound 1 (AG7404)

Summary for 3Q3Y
Entry DOI10.2210/pdb3q3y/pdb
Related3Q3X
DescriptorHEVB EV93 3C protease, ethyl (4R)-4-({(2S)-2-[3-{[(5-methyl-1,2-oxazol-3-yl)carbonyl]amino}-2-oxopyridin-1(2H)-yl]pent-4-ynoyl}amino)-5-[(3S)-2-oxopyrrolidin-3-yl]pentanoate, 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywordscysteine trypsin-like protease, 3c cysteine protease (picornain 3c), antiviral compound 1 (ag7404), hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHuman enterovirus B
Total number of polymer chains2
Total formula weight44662.69
Authors
Costenaro, L.,Kaczmarska, Z.,Arnan, C.,Sola, M.,Coutard, B.,Norder, H.,Canard, B.,Coll, M. (deposition date: 2010-12-22, release date: 2011-09-07, Last modification date: 2023-09-13)
Primary citationCostenaro, L.,Kaczmarska, Z.,Arnan, C.,Janowski, R.,Coutard, B.,Sola, M.,Gorbalenya, A.E.,Norder, H.,Canard, B.,Coll, M.
Structural Basis for Antiviral Inhibition of the Main Protease, 3C, from Human Enterovirus 93.
J.Virol., 85:10764-10773, 2011
Cited by
PubMed: 21835784
DOI: 10.1128/JVI.05062-11
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.32 Å)
Structure validation

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