6X70
 
 | | Rev1-DNA Binary Complex | | Descriptor: | DNA (5'-D(*CP*AP*TP*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*GP*TP*GP*TP*GP*GP*TP*AP*G)-3'), DNA repair protein REV1, ... | | Authors: | Weaver, T.M, Freudenthal, B.D. | | Deposit date: | 2020-05-29 | | Release date: | 2020-09-30 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Visualizing Rev1 catalyze protein-template DNA synthesis.
Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6X77
 | | Rev1 R518A Ternary Complex with dCTP and Ca2+ | | Descriptor: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(P*AP*TP*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3'), ... | | Authors: | Weaver, T.M, Freudenthal, B.D. | | Deposit date: | 2020-05-29 | | Release date: | 2020-09-30 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.64 Å) | | Cite: | Visualizing Rev1 catalyze protein-template DNA synthesis.
Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
6X74
 | | Rev1 Mg2+-facilitated Product Complex with no monophosphates | | Descriptor: | CHLORIDE ION, DNA (5'-D(*GP*GP*GP*GP*TP*GP*TP*GP*GP*TP*AP*GP*C*)-3'), DNA (5'-D(P*AP*TP*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3'), ... | | Authors: | Weaver, T.M, Freudenthal, B.D. | | Deposit date: | 2020-05-29 | | Release date: | 2020-09-30 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Visualizing Rev1 catalyze protein-template DNA synthesis.
Proc.Natl.Acad.Sci.USA, 117, 2020
|
|
5HM4
 | | Crystal structure of oligopeptide ABC transporter, periplasmic oligopeptide-binding protein (TM1226) from THERMOTOGA MARITIMA at 2.0 A resolution | | Descriptor: | CALCIUM ION, Mannoside ABC transport system, sugar-binding protein | | Authors: | Lu, X, Ghimire-Rijal, S, Myles, D.A.A, Cuneo, M.J. | | Deposit date: | 2016-01-15 | | Release date: | 2016-11-23 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Periplasmic Binding Protein Dimer Has a Second Allosteric Event Tied to Ligand Binding.
Biochemistry, 56, 2017
|
|
6MV6
 | | Crystal structure of RNAse 6 | | Descriptor: | PHOSPHATE ION, Ribonuclease K6 | | Authors: | Couture, J.-F, Doucet, N. | | Deposit date: | 2018-10-24 | | Release date: | 2019-11-13 | | Last modified: | 2020-05-27 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Insights into Structural and Dynamical Changes Experienced by Human RNase 6 upon Ligand Binding.
Biochemistry, 59, 2020
|
|
6MV7
 | | Crystal structure of RNAse 6 | | Descriptor: | ADENOSINE MONOPHOSPHATE, Ribonuclease K6 | | Authors: | Couture, J.-F, Doucet, N. | | Deposit date: | 2018-10-24 | | Release date: | 2019-11-13 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.59 Å) | | Cite: | Insights into Structural and Dynamical Changes Experienced by Human RNase 6 upon Ligand Binding.
Biochemistry, 59, 2020
|
|
6NP4
 | | AAC-VIa bound to Tobramycin | | Descriptor: | Aminoglycoside N(3)-acetyltransferase, MAGNESIUM ION, TOBRAMYCIN | | Authors: | Kumar, P, Cuneo, M.J. | | Deposit date: | 2019-01-17 | | Release date: | 2019-09-25 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.151 Å) | | Cite: | Low-Barrier and Canonical Hydrogen Bonds Modulate Activity and Specificity of a Catalytic Triad.
Angew.Chem.Int.Ed.Engl., 58, 2019
|
|
6NP1
 | |
6NP3
 | | AAC-VIa bound to Gentamicin | | Descriptor: | (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL, Aminoglycoside N(3)-acetyltransferase, MAGNESIUM ION | | Authors: | Kumar, P, Cuneo, M.J. | | Deposit date: | 2019-01-17 | | Release date: | 2019-09-25 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.15 Å) | | Cite: | Low-Barrier and Canonical Hydrogen Bonds Modulate Activity and Specificity of a Catalytic Triad.
Angew.Chem.Int.Ed.Engl., 58, 2019
|
|
6NP5
 | | AAC-VIa bound to Kanamycin B | | Descriptor: | (1R,2S,3S,4R,6S)-4,6-DIAMINO-3-[(3-AMINO-3-DEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-2-HYDROXYCYCLOHEXYL 2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSIDE, Aminoglycoside N(3)-acetyltransferase, MAGNESIUM ION | | Authors: | Kumar, P, Cuneo, M.J. | | Deposit date: | 2019-01-17 | | Release date: | 2019-09-25 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.353 Å) | | Cite: | Low-Barrier and Canonical Hydrogen Bonds Modulate Activity and Specificity of a Catalytic Triad.
Angew.Chem.Int.Ed.Engl., 58, 2019
|
|
6NTJ
 | | Neutron/X-ray crystal structure of AAC-VIa bound to gentamicin C1A | | Descriptor: | (2R,3R,4R,5R)-2-((1S,2S,3R,4S,6R)-4,6-DIAMINO-3-((2R,3R,6S)-3-AMINO-6-(AMINOMETHYL)-TETRAHYDRO-2H-PYRAN-2-YLOXY)-2-HYDR OXYCYCLOHEXYLOXY)-5-METHYL-4-(METHYLAMINO)-TETRAHYDRO-2H-PYRAN-3,5-DIOL, Aminoglycoside N(3)-acetyltransferase, MAGNESIUM ION | | Authors: | Cuneo, M.J, Kumar, P. | | Deposit date: | 2019-01-29 | | Release date: | 2019-09-25 | | Last modified: | 2024-04-03 | | Method: | NEUTRON DIFFRACTION (1.9 Å), X-RAY DIFFRACTION | | Cite: | Low-Barrier and Canonical Hydrogen Bonds Modulate Activity and Specificity of a Catalytic Triad.
Angew.Chem.Int.Ed.Engl., 58, 2019
|
|
6NP2
 | | AAC-VIa bound to Sisomicin | | Descriptor: | (1S,2S,3R,4S,6R)-4,6-diamino-3-{[(2S,3R)-3-amino-6-(aminomethyl)-3,4-dihydro-2H-pyran-2-yl]oxy}-2-hydroxycyclohexyl 3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranoside, Aminoglycoside N(3)-acetyltransferase, MAGNESIUM ION | | Authors: | Kumar, P, Cuneo, M.J. | | Deposit date: | 2019-01-17 | | Release date: | 2019-09-25 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | Low-Barrier and Canonical Hydrogen Bonds Modulate Activity and Specificity of a Catalytic Triad.
Angew.Chem.Int.Ed.Engl., 58, 2019
|
|
6NTI
 | | Neutron/X-ray crystal structure of AAC-VIa bound to kanamycin b | | Descriptor: | (1R,2S,3S,4R,6S)-4,6-DIAMINO-3-[(3-AMINO-3-DEOXY-ALPHA-D-GLUCOPYRANOSYL)OXY]-2-HYDROXYCYCLOHEXYL 2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSIDE, Aminoglycoside N(3)-acetyltransferase, MAGNESIUM ION | | Authors: | Cuneo, M.J, Kumar, P. | | Deposit date: | 2019-01-29 | | Release date: | 2019-09-25 | | Last modified: | 2024-04-03 | | Method: | NEUTRON DIFFRACTION (2.3 Å), X-RAY DIFFRACTION | | Cite: | Low-Barrier and Canonical Hydrogen Bonds Modulate Activity and Specificity of a Catalytic Triad.
Angew.Chem.Int.Ed.Engl., 58, 2019
|
|
6W4T
 | | APE1 Y269A phosphorothioate substrate complex with abasic DNA | | Descriptor: | DNA (5'-D(*GP*GP*AP*TP*CP*CP*GP*TP*CP*GP*GP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(P*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*(48Z)P*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3'), DNA-(apurinic or apyrimidinic site) lyase | | Authors: | Freudenthal, B.D, Hoitsma, N.M. | | Deposit date: | 2020-03-11 | | Release date: | 2020-06-17 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.77 Å) | | Cite: | AP-endonuclease 1 sculpts DNA through an anchoring tyrosine residue on the DNA intercalating loop.
Nucleic Acids Res., 48, 2020
|
|
6W4I
 | | APE1 Y269A product complex with abasic DNA | | Descriptor: | DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), DNA (5'-D(P*(3DR)P*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3'), DNA (5'-D(P*GP*GP*AP*TP*CP*CP*GP*TP*CP*GP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... | | Authors: | Freudenthal, B.D, Hoitsma, N.M. | | Deposit date: | 2020-03-10 | | Release date: | 2020-06-17 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | AP-endonuclease 1 sculpts DNA through an anchoring tyrosine residue on the DNA intercalating loop.
Nucleic Acids Res., 48, 2020
|
|
5EJ3
 | | Crystal structure of XlnB2 | | Descriptor: | Endo-1,4-beta-xylanase B | | Authors: | Couture, J.-F. | | Deposit date: | 2015-11-01 | | Release date: | 2016-09-07 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.314 Å) | | Cite: | Ligand Binding Enhances Millisecond Conformational Exchange in Xylanase B2 from Streptomyces lividans.
Biochemistry, 55, 2016
|
|
7T1B
 | | Rev1 Ternary Complex with rCTP and Ca2+ | | Descriptor: | CALCIUM ION, CYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*AP*TP*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3'), ... | | Authors: | Freudenthal, B.D, Weaver, T.M. | | Deposit date: | 2021-12-01 | | Release date: | 2022-05-25 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1.
Nat Commun, 13, 2022
|
|
7T1A
 | | Rev1 Ternary Complex with dATP and Ca2+ | | Descriptor: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*AP*TP*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3'), ... | | Authors: | Freudenthal, B.D, Weaver, T.M. | | Deposit date: | 2021-12-01 | | Release date: | 2022-05-25 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.81 Å) | | Cite: | Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1.
Nat Commun, 13, 2022
|
|
7T19
 | | Rev1 Ternary Complex with dGTP and Ca2+ | | Descriptor: | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*CP*AP*TP*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3'), ... | | Authors: | Freudenthal, B.D, Weaver, T.M. | | Deposit date: | 2021-12-01 | | Release date: | 2022-05-25 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1.
Nat Commun, 13, 2022
|
|
7T18
 | | Rev1 Ternary Complex with dTTP and Ca2+ | | Descriptor: | CALCIUM ION, DNA (5'-D(*AP*TP*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3'), DNA (5'-D(P*GP*GP*GP*GP*TP*GP*TP*GP*GP*TP*AP*G)-3'), ... | | Authors: | Freudenthal, B.D, Weaver, T.M. | | Deposit date: | 2021-12-01 | | Release date: | 2022-05-25 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Mechanism of nucleotide discrimination by the translesion synthesis polymerase Rev1.
Nat Commun, 13, 2022
|
|
7T5C
 | |
7T5D
 | |
7T5E
 | |
7TY1
 | | Crystal structure of apo eosinophil cationic protein (ribonuclease 3) from Macaca fascicularis (MfECP) | | Descriptor: | CITRIC ACID, DI(HYDROXYETHYL)ETHER, Eosinophil cationic protein, ... | | Authors: | Tran, T.T.Q, Pham, N.T.H, Calmettes, C, Doucet, N. | | Deposit date: | 2022-02-11 | | Release date: | 2023-08-16 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Ancestral sequence reconstruction dissects structural and functional differences among eosinophil ribonucleases.
J.Biol.Chem., 300, 2024
|
|
5TKI
 | |
