7LPH
APE1 Mn-bound product complex with abasic ribonucleotide DNA
Summary for 7LPH
Entry DOI | 10.2210/pdb7lph/pdb |
Descriptor | DNA-(apurinic or apyrimidinic site) lyase, DNA (5'-D(*GP*GP*AP*TP*CP*CP*GP*TP*CP*GP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), ... (6 entities in total) |
Functional Keywords | dna repair, abasic ribonucleotide, ap-endonuclease, lyase, lyase-dna complex, lyase/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 5 |
Total formula weight | 75104.14 |
Authors | Freudenthal, B.D.,Hoitsma, N.M. (deposition date: 2021-02-11, release date: 2021-08-04, Last modification date: 2023-10-18) |
Primary citation | Hoitsma, N.M.,Click, T.H.,Agarwal, P.K.,Freudenthal, B.D. Altered APE1 activity on abasic ribonucleotides is mediated by changes in the nucleoside sugar pucker. Comput Struct Biotechnol J, 19:3293-3302, 2021 Cited by PubMed: 34188778DOI: 10.1016/j.csbj.2021.05.035 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.99 Å) |
Structure validation
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