7LPI
APE1 phosphorothioate substrate complex with abasic ribonucleotide DNA
Summary for 7LPI
Entry DOI | 10.2210/pdb7lpi/pdb |
Descriptor | DNA-(apurinic or apyrimidinic site) lyase, DNA (5'-D(*GP*GP*AP*TP*CP*CP*GP*TP*CP*GP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-R(P*(YA4))-D(P*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3'), ... (4 entities in total) |
Functional Keywords | dna repair, abasic ribonucleotide, ap-endonuclease, lyase, lyase-dna complex, lyase/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 4 |
Total formula weight | 75110.23 |
Authors | Freudenthal, B.D.,Hoitsma, N.M. (deposition date: 2021-02-11, release date: 2021-08-04, Last modification date: 2023-10-18) |
Primary citation | Hoitsma, N.M.,Click, T.H.,Agarwal, P.K.,Freudenthal, B.D. Altered APE1 activity on abasic ribonucleotides is mediated by changes in the nucleoside sugar pucker. Comput Struct Biotechnol J, 19:3293-3302, 2021 Cited by PubMed: 34188778DOI: 10.1016/j.csbj.2021.05.035 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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