7LPI
APE1 phosphorothioate substrate complex with abasic ribonucleotide DNA
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (B, D) | DNA-(apurinic or apyrimidinic site) lyase | polymer | 276 | 31156.5 | 2 | UniProt (P27695) Pfam (PF03372) | Homo sapiens (Human) | APEX1, APEX nuclease,APEN,Apurinic-apyrimidinic endonuclease 1, APE-1, REF-1, Redox factor-1 |
| 2 | B (C) | DNA (5'-D(*GP*GP*AP*TP*CP*CP*GP*TP*CP*GP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3') | polymer | 21 | 6449.2 | 1 | synthetic construct | ||
| 3 | D (E) | DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-R(P*(YA4))-D(P*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3') | polymer | 21 | 6348.1 | 1 | synthetic construct | ||
| 4 | E, F, G, H (B, C, D, E) | water | water | 18.0 | 190 | Chemie (HOH) |
Sequence modifications
B, D: 43 - 318 (UniProt: P27695)
| PDB | External Database | Details |
|---|---|---|
| Ala 138 | Cys 138 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 75110.2 | |
| All* | Total formula weight | 75110.2 |
