6NP1
Product state mimicry leads to aminoglycoside discrimination in an antibiotic acetyltransferase
Summary for 6NP1
Entry DOI | 10.2210/pdb6np1/pdb |
Descriptor | Aminoglycoside N(3)-acetyltransferase, MAGNESIUM ION (3 entities in total) |
Functional Keywords | antibiotic modifying enzyme, substrate selectivity, antibiotic, transferase |
Biological source | Enterobacter cloacae |
Total number of polymer chains | 1 |
Total formula weight | 28783.00 |
Authors | Kumar, P.,Cuneo, M.J. (deposition date: 2019-01-17, release date: 2019-09-25, Last modification date: 2023-10-11) |
Primary citation | Kumar, P.,Agarwal, P.K.,Waddell, M.B.,Mittag, T.,Serpersu, E.H.,Cuneo, M.J. Low-Barrier and Canonical Hydrogen Bonds Modulate Activity and Specificity of a Catalytic Triad. Angew.Chem.Int.Ed.Engl., 58:16260-16266, 2019 Cited by PubMed: 31515870DOI: 10.1002/anie.201908535 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.6 Å) |
Structure validation
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