7FCH
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![BU of 7fch by Molmil](/molmil-images/mine/7fch) | IL-18Rbeta TIR domain | Descriptor: | Interleukin-18 receptor accessory protein | Authors: | Wang, X, Zhou, J. | Deposit date: | 2021-07-14 | Release date: | 2022-07-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.883 Å) | Cite: | Structural basis of the IL-1 receptor TIR domain-mediated IL-1 signaling Iscience, 25, 2022
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7FD3
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![BU of 7fd3 by Molmil](/molmil-images/mine/7fd3) | IL-1RAPL2 TIR domain | Descriptor: | X-linked interleukin-1 receptor accessory protein-like 2 | Authors: | Wang, X, Zhou, J. | Deposit date: | 2021-07-15 | Release date: | 2022-07-20 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | Structural basis of the IL-1 receptor TIR domain-mediated IL-1 signaling Iscience, 25, 2022
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7FCL
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![BU of 7fcl by Molmil](/molmil-images/mine/7fcl) | Zebrafish SIGIRR TIR domain | Descriptor: | SIGIRR protein | Authors: | Wang, X, Zhou, J. | Deposit date: | 2021-07-15 | Release date: | 2022-07-27 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.04 Å) | Cite: | Structural basis of the IL-1 receptor TIR domain-mediated IL-1 signaling Iscience, 25, 2022
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8JAY
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![BU of 8jay by Molmil](/molmil-images/mine/8jay) | CrtSPARTA Octamer bound with guide-target | Descriptor: | DNA (25-MER), MAGNESIUM ION, Piwi domain-containing protein, ... | Authors: | Guo, L.J, Huang, P.P, Li, Z.X, Xiao, Y.B, Chen, M.R. | Deposit date: | 2023-05-07 | Release date: | 2024-03-20 | Last modified: | 2024-04-10 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system. Nat.Chem.Biol., 20, 2024
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6XFN
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![BU of 6xfn by Molmil](/molmil-images/mine/6xfn) | Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with UAW243 | Descriptor: | 3C-like proteinase, GLYCEROL, UAW243 | Authors: | Sacco, M, Ma, C, Wang, J, Chen, Y. | Deposit date: | 2020-06-15 | Release date: | 2020-06-24 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L. Sci Adv, 6, 2020
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6XBI
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![BU of 6xbi by Molmil](/molmil-images/mine/6xbi) | Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with inhibitor UAW248 | Descriptor: | 3C-like proteinase, DIMETHYL SULFOXIDE, GLYCEROL, ... | Authors: | Sacco, M, Ma, C, Wang, J, Chen, Y. | Deposit date: | 2020-06-06 | Release date: | 2020-06-17 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L. Sci Adv, 6, 2020
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6XA4
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![BU of 6xa4 by Molmil](/molmil-images/mine/6xa4) | Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with UAW241 | Descriptor: | 3C-like proteinase, GLYCEROL, inhibitor UAW241 | Authors: | Sacco, M, Ma, C, Wang, J, Chen, Y. | Deposit date: | 2020-06-03 | Release date: | 2020-06-17 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L. Sci Adv, 6, 2020
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6XBH
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![BU of 6xbh by Molmil](/molmil-images/mine/6xbh) | Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with inhibitor UAW247 | Descriptor: | 3C-like proteinase, GLYCEROL, SODIUM ION, ... | Authors: | Sacco, M, Ma, C, Wang, J, Chen, Y. | Deposit date: | 2020-06-06 | Release date: | 2020-06-17 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L. Sci Adv, 6, 2020
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6XBG
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![BU of 6xbg by Molmil](/molmil-images/mine/6xbg) | Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with inhibitor UAW246 | Descriptor: | 3C-like proteinase, GLYCEROL, SODIUM ION, ... | Authors: | Sacco, M, Ma, C, Wang, J, Chen, Y. | Deposit date: | 2020-06-05 | Release date: | 2020-06-17 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structure and inhibition of the SARS-CoV-2 main protease reveal strategy for developing dual inhibitors against M pro and cathepsin L. Sci Adv, 6, 2020
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8K4F
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![BU of 8k4f by Molmil](/molmil-images/mine/8k4f) | DHODH in complex with compound A0 | Descriptor: | 5-cyclopropyl-2-[1-[(2-fluorophenyl)methyl]pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-4-amine, 6-[bis(oxidanyl)methyl]-5~{H}-pyrimidine-2,4-dione, ACETATE ION, ... | Authors: | Jian, L, Sun, Q. | Deposit date: | 2023-07-18 | Release date: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Discovery and Optimization of Novel h DHODH Inhibitors for the Treatment of Inflammatory Bowel Disease. J.Med.Chem., 66, 2023
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8CIJ
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![BU of 8cij by Molmil](/molmil-images/mine/8cij) | CRYSTAL STRUCTURE OF HUMAN HPK1 (MAP4K1) COMPLEX WITH 2-[8-Amino-7-fluoro-6-(8-methyl-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-7-yl)-isoquinolin-3-ylamino]-6-isopropyl-5,6-dihydro-4H-1,6,8a-triaza-azulen-7-one | Descriptor: | 2-[[8-azanyl-7-fluoranyl-6-(8-methyl-2,3-dihydro-1~{H}-pyrido[2,3-b][1,4]oxazin-7-yl)isoquinolin-3-yl]amino]-6-propan-2-yl-5,8-dihydro-4~{H}-pyrazolo[1,5-d][1,4]diazepin-7-one, Mitogen-activated protein kinase kinase kinase kinase 1 | Authors: | Musil, D, Toure, M. | Deposit date: | 2023-02-09 | Release date: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.821 Å) | Cite: | Discovery of quinazoline HPK1 inhibitors with high cellular potency. Bioorg.Med.Chem., 92, 2023
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8CDW
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![BU of 8cdw by Molmil](/molmil-images/mine/8cdw) | |
1KKX
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![BU of 1kkx by Molmil](/molmil-images/mine/1kkx) | Solution structure of the DNA-binding domain of ADR6 | Descriptor: | Transcription regulatory protein ADR6 | Authors: | Tu, X, Wu, J, Xu, Y, Shi, Y. | Deposit date: | 2001-12-10 | Release date: | 2002-07-17 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | 1H, 13C and 15N resonance assignments and secondary structure of ADR6 DNA-binding domain. J.Biomol.Nmr, 21, 2001
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6J19
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![BU of 6j19 by Molmil](/molmil-images/mine/6j19) | ATPase | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ESAT-6-like protein EsxB, ESX-1 secretion system protein EccCb1, ... | Authors: | Wang, S.H, Li, J, Rao, Z.H. | Deposit date: | 2018-12-28 | Release date: | 2019-12-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.978 Å) | Cite: | Structural insights into substrate recognition by the type VII secretion system. Protein Cell, 11, 2020
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6J18
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![BU of 6j18 by Molmil](/molmil-images/mine/6j18) | ATPase | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ESX-5 secretion system protein EccC5, MAGNESIUM ION | Authors: | Wang, S.H, Li, J, Rao, Z.H. | Deposit date: | 2018-12-28 | Release date: | 2019-12-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural insights into substrate recognition by the type VII secretion system. Protein Cell, 11, 2020
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6JD5
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![BU of 6jd5 by Molmil](/molmil-images/mine/6jd5) | ATPase | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ESX conserved component EccC2. ESX-2 type VII secretion system protein. Possible membrane protein, MAGNESIUM ION | Authors: | Wang, S.H, Li, J, Rao, Z.H. | Deposit date: | 2019-01-31 | Release date: | 2019-12-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural insights into substrate recognition by the type VII secretion system. Protein Cell, 11, 2020
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6J2P
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![BU of 6j2p by Molmil](/molmil-images/mine/6j2p) | |
6J17
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![BU of 6j17 by Molmil](/molmil-images/mine/6j17) | ATPase | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, ESX-3 secretion system protein EccC3, MAGNESIUM ION | Authors: | Wang, S.H, Li, J, Rao, Z.H. | Deposit date: | 2018-12-28 | Release date: | 2019-12-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.975 Å) | Cite: | Structural insights into substrate recognition by the type VII secretion system. Protein Cell, 11, 2020
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6J7J
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![BU of 6j7j by Molmil](/molmil-images/mine/6j7j) | Crystal structure of Pseudomonas aeruginosa Earp | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Pseudomonas aeruginosa Earp | Authors: | He, C, Li, F. | Deposit date: | 2019-01-18 | Release date: | 2019-05-15 | Last modified: | 2019-06-26 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Complex Structure ofPseudomonas aeruginosaArginine Rhamnosyltransferase EarP with Its Acceptor Elongation Factor P. J.Bacteriol., 201, 2019
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6J7K
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![BU of 6j7k by Molmil](/molmil-images/mine/6j7k) | Crystal structure of Pseudomonas aeruginosa Earp in complex with TDP-Rha | Descriptor: | 2'-DEOXY-THYMIDINE-BETA-L-RHAMNOSE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Pseudomonas aeruginosa Earp | Authors: | He, C, Li, F. | Deposit date: | 2019-01-18 | Release date: | 2019-05-15 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Complex Structure ofPseudomonas aeruginosaArginine Rhamnosyltransferase EarP with Its Acceptor Elongation Factor P. J.Bacteriol., 201, 2019
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6J7L
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![BU of 6j7l by Molmil](/molmil-images/mine/6j7l) | Crystal structure of Pseudomonas aeruginosa Earp in complex with TDP | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Pseudomonas aeruginosa Earp, THYMIDINE-5'-DIPHOSPHATE | Authors: | He, C, Li, F. | Deposit date: | 2019-01-18 | Release date: | 2019-05-15 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.851 Å) | Cite: | Complex Structure ofPseudomonas aeruginosaArginine Rhamnosyltransferase EarP with Its Acceptor Elongation Factor P. J.Bacteriol., 201, 2019
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1KN5
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![BU of 1kn5 by Molmil](/molmil-images/mine/1kn5) | SOLUTION STRUCTURE OF ARID DOMAIN OF ADR6 FROM SACCHAROMYCES CEREVISIAE | Descriptor: | Transcription regulatory protein ADR6 | Authors: | Tu, X, Wu, J, Xu, Y, Shi, Y. | Deposit date: | 2001-12-18 | Release date: | 2002-07-17 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | 1H, 13C and 15N resonance assignments and secondary structure of ADR6 DNA-binding domain. J.Biomol.Nmr, 21, 2001
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8J0K
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![BU of 8j0k by Molmil](/molmil-images/mine/8j0k) | Crystal structure of human TFAP2A in complex with DNA | Descriptor: | DNA (5'-D(*CP*TP*GP*CP*CP*TP*CP*GP*GP*GP*CP*AP*C)-3'), DNA (5'-D(*GP*TP*GP*CP*CP*CP*GP*AP*GP*GP*CP*AP*G)-3'), GLYCEROL, ... | Authors: | Liu, K, Xiao, Y.Q, Li, W.F, Min, J.R. | Deposit date: | 2023-04-11 | Release date: | 2023-07-05 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis for specific DNA sequence motif recognition by the TFAP2 transcription factors. Nucleic Acids Res., 51, 2023
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8J0Q
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![BU of 8j0q by Molmil](/molmil-images/mine/8j0q) | Structure of DNA binding domain of human TFAP2B | Descriptor: | GLYCEROL, Transcription factor AP-2-beta | Authors: | Liu, K, Xiao, Y.Q, Li, W.F, Min, J.R. | Deposit date: | 2023-04-11 | Release date: | 2023-07-05 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for specific DNA sequence motif recognition by the TFAP2 transcription factors. Nucleic Acids Res., 51, 2023
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8J0L
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![BU of 8j0l by Molmil](/molmil-images/mine/8j0l) | Structure of DNA binding Domain of Human TFAP2A | Descriptor: | GLYCEROL, Transcription factor AP-2-alpha | Authors: | Liu, K, Xiao, Y.Q, Gan, L.Y, Min, J.R. | Deposit date: | 2023-04-11 | Release date: | 2023-07-05 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | Structural basis for specific DNA sequence motif recognition by the TFAP2 transcription factors. Nucleic Acids Res., 51, 2023
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