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5FON
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BU of 5fon by Molmil
Crystal structure of the Cryptosporidium muris cytosolic leucyl-tRNA synthetase editing domain (apo structure)
Descriptor: LEUCYL-TRNA SYNTHETASE
Authors:Palencia, A, Liu, R.J, Lukarska, M, Gut, J, Bougdour, A, Touquet, B, Wang, E.D, Alley, M.R.K, Rosenthal, P.J, Hakimi, M.A, Cusack, S.
Deposit date:2015-11-24
Release date:2016-08-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Cryptosporidium and Toxoplasma Parasites are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
6YEL
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BU of 6yel by Molmil
Stromal interaction molecule 1 coiled-coil 1 fragment
Descriptor: Stromal interaction molecule 1
Authors:Rathner, P, Cerofolini, L, Ravera, E, Bechmann, M, Grabmayr, H, Fahrner, M, Fragai, M, Romanin, C, Luchinat, C, Mueller, N.
Deposit date:2020-03-25
Release date:2020-09-02
Last modified:2024-06-19
Method:SOLUTION NMR
Cite:Interhelical interactions within the STIM1 CC1 domain modulate CRAC channel activation.
Nat.Chem.Biol., 17, 2021
4UX9
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BU of 4ux9 by Molmil
Crystal structure of JNK1 bound to a MKK7 docking motif
Descriptor: DUAL SPECIFICITY MITOGEN-ACTIVATED PROTEIN KINASE KINASE 7, MITOGEN-ACTIVATED PROTEIN KINASE 8, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Kragelj, J, Palencia, A, Nanao, M.H, Maurin, D, Bouvignies, G, Blackledge, M, Ringkjobing-Jensen, M.
Deposit date:2014-08-20
Release date:2015-03-25
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Structure and Dynamics of the Mkk7-Jnk Signaling Complex.
Proc.Natl.Acad.Sci.USA, 112, 2015
5FGG
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BU of 5fgg by Molmil
Yeast 20S proteasome beta5-L(-49S)_D17N double mutant in complex with Carfilzomib
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Huber, E.M, Groll, M.
Deposit date:2015-12-20
Release date:2016-03-23
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome.
Nat Commun, 7, 2016
5FOG
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BU of 5fog by Molmil
Crystal structure of hte Cryptosporidium muris cytosolic leucyl-tRNA synthetase editing domain complex with a post-transfer editing analogue of norvaline (Nv2AA)
Descriptor: 1,2-ETHANEDIOL, 2'-(L-NORVALYL)AMINO-2'-DEOXYADENOSINE, LEUCYL-TRNA SYNTHETASE, ...
Authors:Palencia, A, Liu, R.J, Lukarska, M, Gut, J, Bougdour, A, Touquet, B, Wang, E.D, Alley, M.R.K, Rosenthal, P.J, Hakimi, M.A, Cusack, S.
Deposit date:2015-11-20
Release date:2016-08-03
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Cryptosporidium and Toxoplasma Parasites are Inhibited by a Benzoxaborole Targeting Leucyl-tRNA Synthetase.
Antimicrob.Agents Chemother., 60, 2016
4V2T
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BU of 4v2t by Molmil
Membrane embedded pleurotolysin pore with 13 fold symmetry
Descriptor: PLEUROTOLYSIN A, PLEUROTOLYSIN B
Authors:Lukoyanova, N, Kondos, S.C, Farabella, I, Law, R.H.P, Reboul, C.F, Caradoc-Davies, T.T, Spicer, B.A, Kleifeld, O, Perugini, M, Ekkel, S, Hatfaludi, T, Oliver, K, Hotze, E.M, Tweten, R.K, Whisstock, J.C, Topf, M, Dunstone, M.A, Saibil, H.R.
Deposit date:2014-10-15
Release date:2015-02-18
Last modified:2024-05-08
Method:ELECTRON MICROSCOPY (11 Å)
Cite:Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin.
Plos Biol., 13, 2015
6T0Q
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BU of 6t0q by Molmil
Pleurotus Ostreatus Lectin (POL), apo form
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Destefanis, L, Perduca, M, Bovi, M, Monaco, H.L, Capaldi, S.
Deposit date:2019-10-03
Release date:2020-02-19
Last modified:2022-12-07
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure and properties of the oyster mushroom (Pleurotus ostreatus) lectin.
Glycobiology, 30, 2020
6T1D
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BU of 6t1d by Molmil
Pleurotus Ostreatus Lectin (POL), compelx with melibiose
Descriptor: CALCIUM ION, Lectin, alpha-D-galactopyranose-(1-6)-alpha-D-glucopyranose
Authors:Destefanis, L, Perduca, M, Bovi, M, Monaco, H.L, Capaldi, S.
Deposit date:2019-10-04
Release date:2020-02-19
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and properties of the oyster mushroom (Pleurotus ostreatus) lectin.
Glycobiology, 30, 2020
6CJ0
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BU of 6cj0 by Molmil
Chromosomal trehalose-6-phosphate phosphatase from P. aeruginosa
Descriptor: CARBONATE ION, MAGNESIUM ION, Trehalose phosphatase
Authors:Hofmann, A, Cross, M, Park, S.-Y.
Deposit date:2018-02-25
Release date:2018-05-09
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Trehalose 6-phosphate phosphatases of Pseudomonas aeruginosa.
FASEB J., 32, 2018
8AW0
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BU of 8aw0 by Molmil
Crystal structure of PksD, the trans-acting acyl hydrolase domain from the bacillaene trans-AT PKS (native)
Descriptor: Polyketide biosynthesis acyltransferase homolog PksD, ZINC ION
Authors:Fage, C.D, Challis, G.L, Lewandowski, J, Jenner, M.
Deposit date:2022-08-28
Release date:2023-08-09
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis for acyl hydrolysis in trans-AT polyketide synthases
To Be Published
5FSB
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BU of 5fsb by Molmil
Structure of tectonin 2 from laccaria bicolor in complex with 2-o-methyl-methyl-seleno-beta-l-fucopyranoside
Descriptor: BORIC ACID, MAGNESIUM ION, SULFATE ION, ...
Authors:Sommer, R, Bleuer, S, Titz, A, Kunzler, M, Varrot, A.
Deposit date:2016-01-04
Release date:2017-03-29
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal Structures of Fungal Tectonin in Complex with O-Methylated Glycans Suggest Key Role in Innate Immune Defense.
Structure, 26, 2018
8AVZ
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BU of 8avz by Molmil
Crystal structure of PksD, the trans-acting acyl hydrolase domain from the bacillaene trans-AT PKS (SeMet derivative)
Descriptor: Polyketide biosynthesis acyltransferase homolog PksD, ZINC ION
Authors:Fage, C.D, Challis, G.L, Lewandowski, J, Jenner, M.
Deposit date:2022-08-28
Release date:2023-08-09
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Structural basis for acyl hydrolysis in trans-AT polyketide synthases
To Be Published
6CIJ
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BU of 6cij by Molmil
Cryo-EM structure of mouse RAG1/2 HFC complex containing partial HMGB1 linker(3.9 A)
Descriptor: CALCIUM ION, DNA (30-MER), DNA (41-MER), ...
Authors:Chen, X, Kim, M, Chuenchor, W, Cui, Y, Zhang, X, Zhou, Z.H, Gellert, M, Yang, W.
Deposit date:2018-02-24
Release date:2018-04-25
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cracking the DNA Code for V(D)J Recombination.
Mol. Cell, 70, 2018
7O6U
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BU of 7o6u by Molmil
Crystal structure of the VIN3 VEL polymerising domain (R554A R556D mutant)
Descriptor: Protein VERNALIZATION INSENSITIVE 3
Authors:Fiedler, M, Franco-Echevarria, E, Dean, C, Bienz, M.
Deposit date:2021-04-12
Release date:2022-11-09
Last modified:2022-11-23
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Head-to-tail polymerization by VEL proteins underpins cold-induced Polycomb silencing in flowering control.
Cell Rep, 41, 2022
7O6T
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BU of 7o6t by Molmil
Crystal structure of the polymerising VEL domain of VIN3 (R556D I575D mutant)
Descriptor: MAGNESIUM ION, Protein VERNALIZATION INSENSITIVE 3
Authors:Fiedler, M, Franco-Echevarria, E, Dean, C, Bienz, M.
Deposit date:2021-04-12
Release date:2022-11-09
Last modified:2022-11-23
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Head-to-tail polymerization by VEL proteins underpins cold-induced Polycomb silencing in flowering control.
Cell Rep, 41, 2022
7O6V
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BU of 7o6v by Molmil
Crystal structure of the VEL1 VEL polymerising domain (R643A K645D I664D mutant)
Descriptor: VIN3-like protein 2
Authors:Fiedler, M, Franco-Echevarria, E, Dean, C, Bienz, M.
Deposit date:2021-04-12
Release date:2022-11-09
Last modified:2022-11-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Head-to-tail polymerization by VEL proteins underpins cold-induced Polycomb silencing in flowering control.
Cell Rep, 41, 2022
7O6W
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BU of 7o6w by Molmil
Crystal structure of (the) VEL1 VEL polymerising domain (I664D mutant)
Descriptor: PHOSPHATE ION, VIN3-like protein 2
Authors:Fiedler, M, Franco-Echevarria, E, Dean, C, Bienz, M.
Deposit date:2021-04-12
Release date:2022-11-09
Last modified:2024-06-19
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Head-to-tail polymerization by VEL proteins underpins cold-induced Polycomb silencing in flowering control.
Cell Rep, 41, 2022
6ZG0
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BU of 6zg0 by Molmil
SARM1 SAM1-2 domains
Descriptor: 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, DI(HYDROXYETHYL)ETHER, ...
Authors:Sporny, M, Guez-Haddad, J, Khazma, T, Yaron, A, Dessau, M, Mim, C, Isupov, M.N, Zalk, R, Hons, M, Opatowsky, Y.
Deposit date:2020-06-18
Release date:2020-11-11
Last modified:2020-12-09
Method:ELECTRON MICROSCOPY (7.7 Å)
Cite:Structural basis for SARM1 inhibition and activation under energetic stress.
Elife, 9, 2020
5UJC
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BU of 5ujc by Molmil
Crystal structure of a C.elegans B12-trafficking protein CblC, a human MMACHC homologue
Descriptor: CO-METHYLCOBALAMIN, D(-)-TARTARIC ACID, GLYCEROL, ...
Authors:Li, Z, Shanmuganathan, A, Ruetz, M, Yamada, K, Lesniak, N.A, Krautler, B, Brunold, T.C, Banerjee, R, Koutmos, M.
Deposit date:2017-01-17
Release date:2017-05-03
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Coordination chemistry controls the thiol oxidase activity of the B12-trafficking protein CblC.
J. Biol. Chem., 292, 2017
5MP7
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BU of 5mp7 by Molmil
Crystal structure of phosphoribosylpyrophosphate synthetase from Mycobacterium smegmatis
Descriptor: ACETATE ION, Ribose-phosphate pyrophosphokinase
Authors:Donini, S, Garavaglia, S, Ferraris, D.M, Miggiano, R, Mori, S, Shibayama, K, Rizzi, M.
Deposit date:2016-12-16
Release date:2017-04-26
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Biochemical and structural investigations on phosphoribosylpyrophosphate synthetase from Mycobacterium smegmatis.
PLoS ONE, 12, 2017
6Z9M
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BU of 6z9m by Molmil
Pseudoatomic model of the pre-fusion conformation of glycoprotein B of Herpes simplex virus 1
Descriptor: Envelope glycoprotein B
Authors:Vollmer, B, Prazak, V, Vasishtan, D, Jefferys, E.E, Hernandez-Duran, A, Vallbracht, M, Klupp, B, Mettenleiter, T.C, Backovic, M, Rey, F.A, Topf, M, Gruenewald, K.
Deposit date:2020-06-04
Release date:2020-10-07
Last modified:2020-10-14
Method:ELECTRON MICROSCOPY (9.1 Å)
Cite:The prefusion structure of herpes simplex virus glycoprotein B.
Sci Adv, 6, 2020
5UPU
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BU of 5upu by Molmil
Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis in the presence of TBK6
Descriptor: INOSINIC ACID, Inosine-5'-monophosphate dehydrogenase, ~{N}-(2~{H}-indazol-6-yl)-3,5-dimethyl-1~{H}-pyrazole-4-sulfonamide
Authors:Kim, Y, Makowska-Grzyska, M, Maltseva, N, Mulligan, R, Gu, M, Sacchettini, J, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2017-02-04
Release date:2017-02-22
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.905 Å)
Cite:Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Mycobacterium tuberculosis in the presence of TBK6
To Be Published
6TNB
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BU of 6tnb by Molmil
X-RAY STRUCTURE OF MPS1 IN COMPLEX WITH COMPOUND 41
Descriptor: (2~{R})-2-(4-fluorophenyl)-~{N}-[4-[2-[(2-methoxy-4-methylsulfonyl-phenyl)amino]-[1,2,4]triazolo[1,5-a]pyridin-6-yl]phenyl]propanamide, CHLORIDE ION, Dual specificity protein kinase TTK
Authors:Holton, S.J, Schulze, V.K, Klar, U, Kosemund, D, Siemeister, G, Bader, B, Prechtl, S, Briem, H, Marquardt, T, Schirok, H, Bohlmann, R, Nguyen, D, Fernandez-Montalvan, A, Boemer, U, Eberspaecher, U, Brands, M, Nussbaum, F, Koppitz, M.
Deposit date:2019-12-06
Release date:2020-05-13
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase.
J.Med.Chem., 63, 2020
5UQG
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BU of 5uqg by Molmil
Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Campylobacter jejuni in the complex with inhibitor p200
Descriptor: 1,2-ETHANEDIOL, 3-(2-{[(4-chlorophenyl)carbamoyl]amino}propan-2-yl)-N-hydroxybenzene-1-carboximidamide, INOSINIC ACID, ...
Authors:Kim, Y, Maltseva, N, Makowska-Grzyska, M, Gu, M, Gollapalli, D, Hedstrom, L, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2017-02-08
Release date:2017-03-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Crystal Structure of the Catalytic Domain of the Inosine Monophosphate Dehydrogenase from Campylobacter jejuni in the complex with inhibitor p200
To Be Published
2IDF
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BU of 2idf by Molmil
P. aeruginosa azurin N42C/M64E double mutant, BMME-linked dimer
Descriptor: 1-[PYRROL-1-YL-2,5-DIONE-METHOXYMETHYL]-PYRROLE-2,5-DIONE, Azurin, COPPER (II) ION, ...
Authors:Einsle, O, de Jongh, T.E, Hoffmann, M, Cavazzini, D, Rossi, G.L, Ubbink, M, Canters, G.W.
Deposit date:2006-09-15
Release date:2008-03-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Electron transfer in a crosslinked protein dimer mediated by a hydrogen-bonded network across the dimer interface
To be Published

221716

數據於2024-06-26公開中

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