8AW0

Crystal structure of PksD, the trans-acting acyl hydrolase domain from the bacillaene trans-AT PKS (native)

Summary for 8AW0

• Entry DOI: 10.2210/pdb8aw0/pdb
• Related: 8AVZ
• Descriptor: Polyketide biosynthesis acyltransferase homolog PksD, ZINC ION (3 entities in total)
• Functional Keywords: alpha/beta-hydrolase, acyltransferase, polyketide synthase, biosynthesis, hydrolase
• Biological source: Bacillus subtilis subsp. subtilis str. 168
• Total number of polymer chains: 8
• Total formula weight: 297353.29

Authors

Fage, C.D.,Challis, G.L.,Lewandowski, J.,Jenner, M. (deposition date: 2022-08-28, release date: 2023-08-09, Last modification date: 2025-02-05)

• Primary citation: Fage, C.D.,Passmore, M.,Tatman, B.P.,Smith, H.G.,Jian, X.,Dissanayake, U.C.,Foran, M.E.,Cisneros, G.A.,Challis, G.L.,Lewandowski, J.R.,Jenner, M.; Molecular Basis for Short-Chain Thioester Hydrolysis by Acyl Hydrolases in trans-Acyltransferase Polyketide Synthases; Jacs Au, 2025; DOI: 10.1021/jacsau.4c00837

Experimental method

X-RAY DIFFRACTION (2.2 Å)