8K13
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![BU of 8k13 by Molmil](/molmil-images/mine/8k13) | SID1 transmembrane family member 1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, SID1 transmembrane family member 1 | Authors: | Guo, H, Qi, C, Lu, Y, Yang, H, Zhu, Y, Sun, F, Ji, X. | Deposit date: | 2023-07-10 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.33 Å) | Cite: | Cryo-EM structures of human SID-1 transmembrane family proteins and implications for their low-pH-dependent RNA transport activity. Cell Res., 34, 2024
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8K1D
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![BU of 8k1d by Molmil](/molmil-images/mine/8k1d) | SID1 transmembrane family member 1 | Descriptor: | SID1 transmembrane family member 1 | Authors: | Guo, H, Qi, C, Lu, Y, Yang, H, Zhu, Y, Sun, F, Ji, X. | Deposit date: | 2023-07-10 | Release date: | 2024-07-10 | Method: | ELECTRON MICROSCOPY (3.53 Å) | Cite: | Cryo-EM structures of human SID-1 transmembrane family proteins and implications for their low-pH-dependent RNA transport activity. Cell Res., 34, 2024
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2MFQ
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![BU of 2mfq by Molmil](/molmil-images/mine/2mfq) | |
5TCZ
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![BU of 5tcz by Molmil](/molmil-images/mine/5tcz) | |
3HR5
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![BU of 3hr5 by Molmil](/molmil-images/mine/3hr5) | |
3C8G
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![BU of 3c8g by Molmil](/molmil-images/mine/3c8g) | Crystal structure of a possible transciptional regulator YggD from Shigella flexneri 2a str. 2457T | Descriptor: | ACETATE ION, Putative transcriptional regulator | Authors: | Tan, K, Borovilos, M, Clancy, S, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2008-02-12 | Release date: | 2008-02-19 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The mannitol operon repressor MtlR belongs to a new class of transcription regulators in bacteria. J.Biol.Chem., 284, 2009
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5TZT
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![BU of 5tzt by Molmil](/molmil-images/mine/5tzt) | Crystal structure of human CD47 ECD bound to Fab of C47B161 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Heavy Chain of Fab C47B161, ... | Authors: | Cardoso, R.M.F. | Deposit date: | 2016-11-22 | Release date: | 2017-03-15 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Anti-leukemic activity and tolerability of anti-human CD47 monoclonal antibodies. Blood Cancer J, 7, 2017
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5TZU
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![BU of 5tzu by Molmil](/molmil-images/mine/5tzu) | Crystal structure of human CD47 ECD bound to Fab of B6H12.2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ... | Authors: | Cardoso, R.M.F. | Deposit date: | 2016-11-22 | Release date: | 2017-03-15 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Anti-leukemic activity and tolerability of anti-human CD47 monoclonal antibodies. Blood Cancer J, 7, 2017
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7MDN
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![BU of 7mdn by Molmil](/molmil-images/mine/7mdn) | Histone-lysine N-methyltransferase NSD2-PWWP1 with compound MRT10241866a | Descriptor: | Histone-lysine N-methyltransferase NSD2, UNKNOWN ATOM OR ION, ~{N}-cyclopropyl-3-oxidanylidene-~{N}-(thiophen-2-ylmethyl)-4~{H}-1,4-benzoxazine-7-carboxamide | Authors: | Lei, M, Freitas, R.F, Dong, A, Schapira, M, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2021-04-05 | Release date: | 2021-05-05 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization. Nat.Chem.Biol., 18, 2022
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3DWH
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5TZ2
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![BU of 5tz2 by Molmil](/molmil-images/mine/5tz2) | Crystal structure of human CD47 ECD bound to Fab of C47B222 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C47B222 Fab Heavy Chain, ... | Authors: | Cardoso, R.M.F. | Deposit date: | 2016-11-21 | Release date: | 2017-03-15 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.302 Å) | Cite: | Anti-leukemic activity and tolerability of anti-human CD47 monoclonal antibodies. Blood Cancer J, 7, 2017
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5VC8
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![BU of 5vc8 by Molmil](/molmil-images/mine/5vc8) | Crystal structure of the WHSC1 PWWP1 domain | Descriptor: | DNA (5'-D(P*CP*TP*(DN))-3'), Histone-lysine N-methyltransferase NSD2, UNKNOWN ATOM OR ION, ... | Authors: | Qin, S, Tempel, W, Dong, A, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2017-03-31 | Release date: | 2017-06-28 | Last modified: | 2021-08-04 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Histone and DNA binding ability studies of the NSD subfamily of PWWP domains. Biochem.Biophys.Res.Commun., 569, 2021
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6XCG
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![BU of 6xcg by Molmil](/molmil-images/mine/6xcg) | Histone-lysine N-methyltransferase NSD2-PWWP1 with compound UNC6934 | Descriptor: | Histone-lysine N-methyltransferase NSD2, N-cyclopropyl-3-oxo-N-({4-[(pyrimidin-4-yl)carbamoyl]phenyl}methyl)-3,4-dihydro-2H-1,4-benzoxazine-7-carboxamide, UNKNOWN ATOM OR ION | Authors: | Zhou, M.Q, Dong, A, Ingerman, L.A, Hanley, R.P, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | Deposit date: | 2020-06-08 | Release date: | 2020-07-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization. Nat.Chem.Biol., 18, 2022
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8AYV
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![BU of 8ayv by Molmil](/molmil-images/mine/8ayv) | |
5GMZ
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![BU of 5gmz by Molmil](/molmil-images/mine/5gmz) | Hepatitis B virus core protein Y132A mutant in complex with 4-methyl heteroaryldihydropyrimidine | Descriptor: | (2S)-4,4-difluoro-1-[[(4S)-4-(4-fluorophenyl)-5-methoxycarbonyl-4-methyl-2-(1,3-thiazol-2-yl)-1H-pyrimidin-6-yl]methyl]pyrrolidine-2-carboxylic acid, CHLORIDE ION, Core protein, ... | Authors: | Xu, Z.H, Zhou, Z. | Deposit date: | 2016-07-18 | Release date: | 2016-08-10 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Design and Synthesis of Orally Bioavailable 4-Methyl Heteroaryldihydropyrimidine Based Hepatitis B Virus (HBV) Capsid Inhibitors J.Med.Chem., 59, 2016
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4FZ7
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![BU of 4fz7 by Molmil](/molmil-images/mine/4fz7) | |
2NDF
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![BU of 2ndf by Molmil](/molmil-images/mine/2ndf) | |
2NDG
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![BU of 2ndg by Molmil](/molmil-images/mine/2ndg) | |
2ND0
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![BU of 2nd0 by Molmil](/molmil-images/mine/2nd0) | |
4GFG
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![BU of 4gfg by Molmil](/molmil-images/mine/4gfg) | Crystal structure of spleen tyrosine kinase complexed with r9021 | Descriptor: | 6-{[(1R,2S)-2-aminocyclohexyl]amino}-4-[(5,6-dimethylpyridin-2-yl)amino]pyridazine-3-carboxamide, Tyrosine-protein kinase SYK | Authors: | Lukacs, C, Slade, M. | Deposit date: | 2012-08-03 | Release date: | 2013-08-14 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | A specific SYK inhibitor blocks B Cell Receptor, Fc Receptor, and Toll-like Receptor 9 pathways for the treatment of inflammatory diseases. To be Published
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2NCZ
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2ND1
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![BU of 2nd1 by Molmil](/molmil-images/mine/2nd1) | |
2LMZ
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![BU of 2lmz by Molmil](/molmil-images/mine/2lmz) | |
4B2T
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![BU of 4b2t by Molmil](/molmil-images/mine/4b2t) | The crystal structures of the eukaryotic chaperonin CCT reveal its functional partitioning | Descriptor: | T-COMPLEX PROTEIN 1 SUBUNIT ALPHA, T-COMPLEX PROTEIN 1 SUBUNIT BETA, T-COMPLEX PROTEIN 1 SUBUNIT DELTA, ... | Authors: | Kalisman, N, Schroeder, G.F, Levitt, M. | Deposit date: | 2012-07-17 | Release date: | 2013-03-20 | Last modified: | 2019-11-06 | Method: | X-RAY DIFFRACTION (5.5 Å) | Cite: | The Crystal Structures of the Eukaryotic Chaperonin Cct Reveal its Functional Partitioning Structure, 21, 2013
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4I0S
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![BU of 4i0s by Molmil](/molmil-images/mine/4i0s) | |