5VC8

Crystal structure of the WHSC1 PWWP1 domain

Summary for 5VC8

• Entry DOI: 10.2210/pdb5vc8/pdb
• Descriptor: Histone-lysine N-methyltransferase NSD2, dodeca-2-deoxy-nucleotide, poorly resolved by electron density, DNA (5'-D(P*CP*TP*(DN))-3'), ... (5 entities in total)
• Functional Keywords: pwwp domain, structural genomics consortium, dna binding protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Nucleus . Isoform 4: Cytoplasm: O96028
• Total number of polymer chains: 6
• Total formula weight: 44130.07

Authors

Qin, S.,Tempel, W.,Dong, A.,Bountra, C.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Min, J.,Structural Genomics Consortium (SGC) (deposition date: 2017-03-31, release date: 2017-06-28, Last modification date: 2021-08-04)

• Primary citation: Zhang, M.,Yang, Y.,Zhou, M.,Dong, A.,Yan, X.,Loppnau, P.,Min, J.,Liu, Y.; Histone and DNA binding ability studies of the NSD subfamily of PWWP domains.; Biochem.Biophys.Res.Commun., 569:199-206, 2021; PubMed: 34271259; DOI: 10.1016/j.bbrc.2021.07.017

Experimental method

X-RAY DIFFRACTION (1.8 Å)