6XCG

Histone-lysine N-methyltransferase NSD2-PWWP1 with compound UNC6934

Summary for 6XCG

• Entry DOI: 10.2210/pdb6xcg/pdb
• Descriptor: Histone-lysine N-methyltransferase NSD2, N-cyclopropyl-3-oxo-N-({4-[(pyrimidin-4-yl)carbamoyl]phenyl}methyl)-3,4-dihydro-2H-1,4-benzoxazine-7-carboxamide, UNKNOWN ATOM OR ION, ... (4 entities in total)
• Functional Keywords: nsd2-pwwp, structural genomics, structural genomics consortium, sgc, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 3
• Total formula weight: 49770.30

Authors

Zhou, M.Q.,Dong, A.,Ingerman, L.A.,Hanley, R.P.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Min, J.,Structural Genomics Consortium (SGC) (deposition date: 2020-06-08, release date: 2020-07-22, Last modification date: 2023-10-18)

• Primary citation: Dilworth, D.,Hanley, R.P.,Ferreira de Freitas, R.,Allali-Hassani, A.,Zhou, M.,Mehta, N.,Marunde, M.R.,Ackloo, S.,Carvalho Machado, R.A.,Khalili Yazdi, A.,Owens, D.D.G.,Vu, V.,Nie, D.Y.,Alqazzaz, M.,Marcon, E.,Li, F.,Chau, I.,Bolotokova, A.,Qin, S.,Lei, M.,Liu, Y.,Szewczyk, M.M.,Dong, A.,Kazemzadeh, S.,Abramyan, T.,Popova, I.K.,Hall, N.W.,Meiners, M.J.,Cheek, M.A.,Gibson, E.,Kireev, D.,Greenblatt, J.F.,Keogh, M.C.,Min, J.,Brown, P.J.,Vedadi, M.,Arrowsmith, C.H.,Barsyte-Lovejoy, D.,James, L.I.,Schapira, M.; A chemical probe targeting the PWWP domain alters NSD2 nucleolar localization.; Nat.Chem.Biol., 18:56-63, 2022; PubMed: 34782742; DOI: 10.1038/s41589-021-00898-0

Experimental method

X-RAY DIFFRACTION (1.64 Å)