7VB4
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6LR1
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8KG5
| Prefusion RSV F Bound to Lonafarnib and D25 Fab | Descriptor: | 4-{2-[4-(3,10-DIBROMO-8-CHLORO-6,11-DIHYDRO-5H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDIN-11-YL)PIPERIDIN-1-YL]-2-OXOETHYL}PIPERIDINE-1-CARBOXAMIDE, D25 heavy chain, D25 light chain, ... | Authors: | Yang, Q, Xue, B, Liu, F, Peng, W, Chen, X. | Deposit date: | 2023-08-17 | Release date: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.17 Å) | Cite: | Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein. Signal Transduct Target Ther, 9, 2024
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7WRO
| Local structure of BD55-3372 and delta spike | Descriptor: | 3372H, 3372L, Spike protein S1 | Authors: | Liu, P.L. | Deposit date: | 2022-01-27 | Release date: | 2022-06-22 | Last modified: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection. Nature, 608, 2022
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7WR8
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7WRL
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7WRZ
| Local resolution of BD55-5840 Fab and SARS-COV2 Omicron RBD | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BD55-5840H, BD55-5840L, ... | Authors: | Zhang, Z.Z, Xiao, J.J. | Deposit date: | 2022-01-28 | Release date: | 2022-06-22 | Last modified: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (3.26 Å) | Cite: | BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection. Nature, 608, 2022
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7XNS
| SARS-CoV-2 Omicron BA.2.12.1 variant spike | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | Authors: | Wang, X, Wang, L. | Deposit date: | 2022-04-29 | Release date: | 2022-07-13 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.48 Å) | Cite: | BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection. Nature, 608, 2022
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7XIX
| SARS-CoV-2 Omicron BA.2 variant spike (state 2) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | Authors: | Wang, X, Wang, L. | Deposit date: | 2022-04-14 | Release date: | 2022-07-13 | Last modified: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection. Nature, 608, 2022
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7XIY
| SARS-CoV-2 Omicron BA.3 variant spike | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | Authors: | Wang, X, Wang, L. | Deposit date: | 2022-04-14 | Release date: | 2022-07-13 | Last modified: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection. Nature, 608, 2022
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7XNQ
| SARS-CoV-2 Omicron BA.4 variant spike | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | Authors: | Wang, X, Wang, L. | Deposit date: | 2022-04-29 | Release date: | 2022-07-13 | Last modified: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (3.52 Å) | Cite: | BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection. Nature, 608, 2022
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7XIW
| SARS-CoV-2 Omicron BA.2 variant spike (state 1) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | Authors: | Wang, X, Wang, L. | Deposit date: | 2022-04-14 | Release date: | 2022-07-13 | Last modified: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (3.62 Å) | Cite: | BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection. Nature, 608, 2022
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7XIZ
| SARS-CoV-2 Omicron BA.3 variant spike (local) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1 | Authors: | Wang, X, Wang, L. | Deposit date: | 2022-04-14 | Release date: | 2022-07-13 | Last modified: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (3.74 Å) | Cite: | BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection. Nature, 608, 2022
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7XNR
| SARS-CoV-2 Omicron BA.2.13 variant spike | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | Authors: | Wang, X, Wang, L. | Deposit date: | 2022-04-29 | Release date: | 2022-07-13 | Last modified: | 2022-08-31 | Method: | ELECTRON MICROSCOPY (3.49 Å) | Cite: | BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection. Nature, 608, 2022
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7X6A
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5E2O
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5E2P
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8JWL
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8JWO
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8JWM
| Crystal structure of AKRtyl-NADP-tylosin complex | Descriptor: | Aldo/keto reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TYLOSIN | Authors: | Lin, S, Dai, S, Xiao, Z. | Deposit date: | 2023-06-29 | Release date: | 2024-04-10 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | A three-level regulatory mechanism of the aldo-keto reductase subfamily AKR12D. Nat Commun, 15, 2024
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8JWK
| The second purified state crystal structure of AKRtyl | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Aldo/keto reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Lin, S, Dai, S, Xiao, Z. | Deposit date: | 2023-06-29 | Release date: | 2024-04-10 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | A three-level regulatory mechanism of the aldo-keto reductase subfamily AKR12D. Nat Commun, 15, 2024
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8JWN
| Crystal structure of AKRtyl-NADPH complex | Descriptor: | Aldo/keto reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | Authors: | Lin, S, Dai, S, Xiao, Z. | Deposit date: | 2023-06-29 | Release date: | 2024-04-10 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | A three-level regulatory mechanism of the aldo-keto reductase subfamily AKR12D. Nat Commun, 15, 2024
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8HJ2
| GPR21 wt with G15 complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Chen, B, Lin, X, Xu, F. | Deposit date: | 2022-11-22 | Release date: | 2023-03-15 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Cryo-EM structures of orphan GPR21 signaling complexes. Nat Commun, 14, 2023
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8HJ0
| GPR21(m5) and G15 complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Chen, B, Lin, X. | Deposit date: | 2022-11-22 | Release date: | 2023-03-15 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Cryo-EM structures of orphan GPR21 signaling complexes. Nat Commun, 14, 2023
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8HIX
| Cryo-EM structure of GPR21_m5_Gs | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | Authors: | Chen, B, Lin, X, Xu, F. | Deposit date: | 2022-11-22 | Release date: | 2023-03-15 | Last modified: | 2023-03-22 | Method: | ELECTRON MICROSCOPY (3.12 Å) | Cite: | Cryo-EM structures of orphan GPR21 signaling complexes. Nat Commun, 14, 2023
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