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8RMQ
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BU of 8rmq by Molmil
Influenza polymerase A/H7N9-4M (ENDO(R) | Core2)
Descriptor: MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:Arragain, B, Cusack, S.
Deposit date:2024-01-08
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (2.54 Å)
Cite:Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase.
Nat Commun, 15, 2024
8RMR
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BU of 8rmr by Molmil
Influenza polymerase A/H7N9-4M replication complex, an asymmetric polymerase dimer bound to human ANP32A
Descriptor: Acidic leucine-rich nuclear phosphoprotein 32 family member A, MAGNESIUM ION, Polymerase acidic protein, ...
Authors:Arragain, B, Cusack, S.
Deposit date:2024-01-08
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase.
Nat Commun, 15, 2024
8RN7
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BU of 8rn7 by Molmil
Pseudo-symmetrical influenza B polymerase apo-dimer, core-only moeity (from "Influenza B polymerase pseudo-symmetrical dimer" | Local refinement)
Descriptor: MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:Arragain, B, Cusack, S.
Deposit date:2024-01-09
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (3.09 Å)
Cite:Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase.
Nat Commun, 15, 2024
8RNB
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BU of 8rnb by Molmil
Influenza B polymerase, encapsidase plus 627(R) / human ANP32A (from "Influenza B polymerase apo-trimer" | Local refinement)
Descriptor: Acidic leucine-rich nuclear phosphoprotein 32 family member A, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:Arragain, B, Cusack, S.
Deposit date:2024-01-09
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (3.31 Å)
Cite:Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase.
Nat Commun, 15, 2024
5AMQ
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BU of 5amq by Molmil
Structure of the La Crosse Bunyavirus polymerase in complex with the 3' and 5' viral RNA
Descriptor: RNA, RNA POLYMERASE L
Authors:Reguera, J, Gerlach, P, Cusack, S.
Deposit date:2015-03-12
Release date:2015-06-03
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Insights Into Bunyavirus Replication and its Regulation by the Vrna Promoter.
Cell, 161, 2015
5AMR
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BU of 5amr by Molmil
Structure of the La Crosse Bunyavirus polymerase in complex with the 3' viral RNA
Descriptor: RNA, RNA POLYMERASE L
Authors:Reguera, J, Gerlach, P, Cusack, S.
Deposit date:2015-03-12
Release date:2015-06-03
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Structural Insights Into Bunyavirus Replication and its Regulation by the Vrna Promoter.
Cell(Cambridge,Mass.), 161, 2015
8RNC
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BU of 8rnc by Molmil
Influenza B polymerase, replication complex, an asymmetric polymerase dimer bound to human ANP32A (from "Influenza B polymerase apo-trimer" | Local refinement)
Descriptor: Acidic leucine-rich nuclear phosphoprotein 32 family member A, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:Arragain, B, Cusack, S.
Deposit date:2024-01-09
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (3.52 Å)
Cite:Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase.
Nat Commun, 15, 2024
8RMS
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BU of 8rms by Molmil
Influenza polymerase A/H7N9-4M replicase minus 627(R) (from "Influenza polymerase A/H7N9-4M replication complex" | Local refinement)
Descriptor: MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:Arragain, B, Cusack, S.
Deposit date:2024-01-08
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase.
Nat Commun, 15, 2024
8RN0
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BU of 8rn0 by Molmil
Influenza polymerase A/H7N9-4M encapsidase plus 627(R) / human ANP32A (from "Influenza polymerase A/H7N9-4M replication complex" | Local refinement)
Descriptor: Acidic leucine-rich nuclear phosphoprotein 32 family member A, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:Arragain, B, Cusack, S.
Deposit date:2024-01-09
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase.
Nat Commun, 15, 2024
8RN1
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BU of 8rn1 by Molmil
Influenza B polymerase, monomeric encapsidase with 5' cRNA hook bound
Descriptor: 5' cRNA hook (1-12), Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:Arragain, B, Cusack, S.
Deposit date:2024-01-09
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (3.64 Å)
Cite:Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase.
Nat Commun, 15, 2024
8RN2
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BU of 8rn2 by Molmil
Monomeric apo-influenza B polymerase, encapsidase conformation
Descriptor: Polymerase acidic protein, Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit
Authors:Arragain, B, Cusack, S.
Deposit date:2024-01-09
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (2.89 Å)
Cite:Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase.
Nat Commun, 15, 2024
8RN4
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BU of 8rn4 by Molmil
Pseudo-symmetrical influenza B polymerase apo-dimer, ENDO(T) moiety (from "Influenza B polymerase pseudo-symmetrical dimer" | Local refinement)
Descriptor: MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:Arragain, B, Cusack, S.
Deposit date:2024-01-09
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (2.87 Å)
Cite:Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase.
Nat Commun, 15, 2024
8RN6
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BU of 8rn6 by Molmil
Pseudo-symmetrical influenza B polymerase apo-dimer, ENDO(E) moiety (from "Influenza B polymerase pseudo-symmetrical dimer" | Local refinement)
Descriptor: Polymerase acidic protein, Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit
Authors:Arragain, B, Cusack, S.
Deposit date:2024-01-09
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (2.82 Å)
Cite:Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase.
Nat Commun, 15, 2024
8RN9
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BU of 8rn9 by Molmil
Influenza B polymerase, replicase (from "Influenza B polymerase apo-trimer" | Local refinement)
Descriptor: Polymerase acidic protein, Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit
Authors:Arragain, B, Cusack, S.
Deposit date:2024-01-09
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (3.31 Å)
Cite:Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase.
Nat Commun, 15, 2024
8RNA
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BU of 8rna by Molmil
Influenza B polymerase apo-trimer
Descriptor: Acidic leucine-rich nuclear phosphoprotein 32 family member A, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:Arragain, B, Cusack, S.
Deposit date:2024-01-09
Release date:2024-09-11
Method:ELECTRON MICROSCOPY (3.57 Å)
Cite:Structures of influenza A and B replication complexes give insight into avian to human host adaptation and reveal a role of ANP32 as an electrostatic chaperone for the apo-polymerase.
Nat Commun, 15, 2024
5D98
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BU of 5d98 by Molmil
Influenza C Virus RNA-dependent RNA Polymerase - Space group P43212
Descriptor: MAGNESIUM ION, Polymerase acidic protein, Polymerase basic protein 2, ...
Authors:Hengrung, N, El Omari, K, Serna Martin, I, Vreede, F.T, Cusack, S, Rambo, R.P, Vonrhein, C, Bricogne, G, Stuart, D.I, Grimes, J.M, Fodor, E.
Deposit date:2015-08-18
Release date:2015-10-21
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Crystal structure of the RNA-dependent RNA polymerase from influenza C virus.
Nature, 527, 2015
5D9A
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BU of 5d9a by Molmil
Influenza C Virus RNA-dependent RNA Polymerase - Space group P212121
Descriptor: Polymerase acidic protein, Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit
Authors:Hengrung, N, El Omari, K, Serna Martin, I, Vreede, F.T, Cusack, S, Rambo, R.P, Vonrhein, C, Bricogne, G, Stuart, D.I, Grimes, J.M, Fodor, E.
Deposit date:2015-08-18
Release date:2015-10-21
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:Crystal structure of the RNA-dependent RNA polymerase from influenza C virus.
Nature, 527, 2015
3ZGZ
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BU of 3zgz by Molmil
Ternary complex of E. coli leucyl-tRNA synthetase, tRNA(leu) and toxic moiety from agrocin 84 (TM84) in aminoacylation-like conformation
Descriptor: LEUCINE--TRNA LIGASE, MAGNESIUM ION, TRNA-LEU UAA ISOACCEPTOR, ...
Authors:Chopra, S, Palencia, A, Virus, C, Tripathy, A, Temple, B.R, Velazquez-Campoy, A, Cusack, S, Reader, J.S.
Deposit date:2012-12-19
Release date:2013-01-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Plant Tumour Biocontrol Agent Employs a tRNA-Dependent Mechanism to Inhibit Leucyl-tRNA Synthetase
Nat.Commun., 4, 2013
4CB7
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BU of 4cb7 by Molmil
Structure of Influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 8e)
Descriptor: 5-[2-(2-azanyl-7-methyl-6-oxidanylidene-1H-purin-9-ium-9-yl)ethanoyl]-2-oxidanyl-benzoic acid, GLYCEROL, POLYMERASE BASIC SUBUNIT 2
Authors:Pautus, S, Sehr, P, Lewis, J, Fortune, A, Wolkerstorfer, A, Szolar, O, Gulligay, D, Lunardi, T, Decout, J.L, Cusack, S.
Deposit date:2013-10-10
Release date:2013-10-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:New 7-Methyl-Guanosine Derivatives Targeting the Influenza Polymerase Pb2 CAP-Binding Domain
J.Med.Chem., 56, 2013
4CB5
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BU of 4cb5 by Molmil
Structure of Influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 8f)
Descriptor: 9-N-(3-CARBOXY-4-HYDROXYPHENYL)KETOMETHYL-7-N-METHYLGUANINE, CHLORIDE ION, POLYMERASE BASIC SUBUNIT 2
Authors:Pautus, S, Sehr, P, Lewis, J, Fortune, A, Wolkerstorfer, A, Szolar, O, Gulligay, D, Lunardi, T, Decout, J.L, Cusack, S.
Deposit date:2013-10-10
Release date:2013-10-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:New 7-Methyl-Guanosine Derivatives Targeting the Influenza Polymerase Pb2 CAP-Binding Domain
J.Med.Chem., 56, 2013
4CB6
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BU of 4cb6 by Molmil
Structure of Influenza A H5N1 PB2 cap-binding domain with bound cap analogue (compound 11)
Descriptor: 2,9-N,N-DI(4-CARBOXYBUTYL)-7-N-METHYLGUANINE, IODIDE ION, POLYMERASE BASIC SUBUNIT 2
Authors:Pautus, S, Sehr, P, Lewis, J, Fortune, A, Wolkerstorfer, A, Szolar, O, Gulligay, D, Lunardi, T, Decout, J.L, Cusack, S.
Deposit date:2013-10-10
Release date:2013-10-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:New 7-Methyl-Guanosine Derivatives Targeting the Influenza Polymerase Pb2 CAP-Binding Domain
J.Med.Chem., 56, 2013
4CB4
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BU of 4cb4 by Molmil
Structure of Influenza A H5N1 PB2 cap-binding domain with bound m7GTP
Descriptor: 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, POLYMERASE BASIC SUBUNIT 2
Authors:Pautus, S, Sehr, P, Lewis, J, Fortune, A, Wolkerstorfer, A, Szolar, O, Gulligay, D, Lunardi, T, Decout, J.L, Cusack, S.
Deposit date:2013-10-10
Release date:2013-10-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:New 7-Methyl-Guanosine Derivatives Targeting the Influenza Polymerase Pb2 CAP-Binding Domain
J.Med.Chem., 56, 2013
1H7Z
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BU of 1h7z by Molmil
Adenovirus Ad3 fibre head
Descriptor: ADENOVIRUS FIBRE PROTEIN, SULFATE ION
Authors:Durmort, C, Stehlin, C, Schoehn, G, Mitraki, A, Drouet, E, Cusack, S, Burmeister, W.P.
Deposit date:2001-01-21
Release date:2001-07-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structure of the Fiber Head of Ad3, a Non-Car-Binding Serotype of Adenovirus
Virology, 285, 2001
1H6K
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BU of 1h6k by Molmil
nuclear Cap Binding Complex
Descriptor: 20 KDA NUCLEAR CAP BINDING PROTEIN, CBP80
Authors:Mazza, C, Ohno, M, Segref, A, Mattaj, I.W, Cusack, S.
Deposit date:2001-06-18
Release date:2001-09-13
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the Human Nuclear CAP Binding Complex
Mol.Cell, 8, 2001
1F5W
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BU of 1f5w by Molmil
DIMERIC STRUCTURE OF THE COXSACKIE VIRUS AND ADENOVIRUS RECEPTOR D1 DOMAIN
Descriptor: COXSACKIE VIRUS AND ADENOVIRUS RECEPTOR, SULFATE ION
Authors:van Raaij, M.J, Chouin, E, van der Zandt, H, Bergelson, J.M, Cusack, S.
Deposit date:2000-06-18
Release date:2000-11-08
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Dimeric structure of the coxsackievirus and adenovirus receptor D1 domain at 1.7 A resolution.
Structure Fold.Des., 8, 2000

238895

數據於2025-07-16公開中

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