4Y7N
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![BU of 4y7n by Molmil](/molmil-images/mine/4y7n) | The Structure Insight into 5-Carboxycytosine Recognition by RNA Polymerase II during Transcription Elongation. | Descriptor: | DNA (29-MER), DNA (5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Wang, L, Chong, J, Wang, D. | Deposit date: | 2015-02-15 | Release date: | 2015-07-15 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex. Nature, 523, 2015
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4Y52
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![BU of 4y52 by Molmil](/molmil-images/mine/4y52) | Crystal structure of 5-Carboxycytosine Recognition by RNA Polymerase II during Transcription Elongation. | Descriptor: | DNA (29-MER), DNA (5'-D(*CP*TP*GP*CP*TP*TP*AP*TP*CP*GP*GP*TP*AP*G)-3'), DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Wang, L, Chong, J, Wang, D. | Deposit date: | 2015-02-11 | Release date: | 2015-07-15 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Molecular basis for 5-carboxycytosine recognition by RNA polymerase II elongation complex. Nature, 523, 2015
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3Q4A
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![BU of 3q4a by Molmil](/molmil-images/mine/3q4a) | |
3Q47
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![BU of 3q47 by Molmil](/molmil-images/mine/3q47) | |
3Q49
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![BU of 3q49 by Molmil](/molmil-images/mine/3q49) | |
6VP0
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![BU of 6vp0 by Molmil](/molmil-images/mine/6vp0) | Human Diacylglycerol Acyltransferase 1 in complex with oleoyl-CoA | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Diacylglycerol O-acyltransferase 1, Lauryl Maltose Neopentyl Glycol, ... | Authors: | Wang, L, Qian, H, Han, Y, Nian, Y, Ren, Z, Zhang, H, Hu, L, Prasad, B.V.V, Yan, N, Zhou, M. | Deposit date: | 2020-02-01 | Release date: | 2020-05-13 | Last modified: | 2023-12-13 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure and mechanism of human diacylglycerol O-acyltransferase 1. Nature, 581, 2020
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3TK9
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![BU of 3tk9 by Molmil](/molmil-images/mine/3tk9) | Crystal structure of human granzyme H | Descriptor: | Granzyme H, SULFATE ION | Authors: | Wang, L, Zhang, K, Wu, L, Tong, L, Sun, F, Fan, Z. | Deposit date: | 2011-08-25 | Release date: | 2011-12-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural insights into the substrate specificity of human granzyme H: the functional roles of a novel RKR motif J.Immunol., 188, 2012
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3TJV
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![BU of 3tjv by Molmil](/molmil-images/mine/3tjv) | Crystal structure of human granzyme H with a peptidyl substrate | Descriptor: | Granzyme H, PTSYAGDDSG, SULFATE ION | Authors: | Wang, L, Zhang, K, Wu, L, Tong, L, Sun, F, Fan, Z. | Deposit date: | 2011-08-25 | Release date: | 2011-12-28 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural insights into the substrate specificity of human granzyme H: the functional roles of a novel RKR motif J.Immunol., 188, 2012
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3TJU
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![BU of 3tju by Molmil](/molmil-images/mine/3tju) | Crystal structure of human granzyme H with an inhibitor | Descriptor: | Ac-PTSY-CMK inhibitor, Granzyme H, SULFATE ION | Authors: | Wang, L, Zhang, K, Wu, L, Tong, L, Sun, F, Fan, Z. | Deposit date: | 2011-08-25 | Release date: | 2011-12-28 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural insights into the substrate specificity of human granzyme H: the functional roles of a novel RKR motif J.Immunol., 188, 2012
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6EGA
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![BU of 6ega by Molmil](/molmil-images/mine/6ega) | IRAK4 in complex with a type II inhibitor | Descriptor: | 3-{2-[(cyclopropanecarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}-N-{4-[(piperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide, COBALT (II) ION, Interleukin-1 receptor-associated kinase 4, ... | Authors: | Wang, L, Wu, H. | Deposit date: | 2018-08-19 | Release date: | 2019-02-20 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.512 Å) | Cite: | Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4). J.Biol.Chem., 294, 2019
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6EG9
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![BU of 6eg9 by Molmil](/molmil-images/mine/6eg9) | IRAK4 in complex with Ponatinib | Descriptor: | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, COBALT (II) ION, Interleukin-1 receptor-associated kinase 4, ... | Authors: | Wang, L, Wu, H. | Deposit date: | 2018-08-19 | Release date: | 2019-02-20 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.414 Å) | Cite: | Conformational flexibility and inhibitor binding to unphosphorylated interleukin-1 receptor-associated kinase 4 (IRAK4). J.Biol.Chem., 294, 2019
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6FXD
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![BU of 6fxd by Molmil](/molmil-images/mine/6fxd) | Crystal structure of MupZ from Pseudomonas fluorescens | Descriptor: | MupZ | Authors: | Wang, L, Parnell, A, Williams, C, Bakar, N.A, van der Kamp, M.W, Simpson, T.J, Race, P.R, Crump, M.P, Willis, C.L. | Deposit date: | 2018-03-08 | Release date: | 2019-03-06 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | A Rieske oxygenase/epoxide hydrolase-catalysed reaction cascade creates oxygen heterocycles in mupirocin biosynthesis Nat Catal, 2018
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6PE0
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![BU of 6pe0 by Molmil](/molmil-images/mine/6pe0) | Msp1 (E214Q)-substrate complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Membrane-spanning ATPase-like protein, ... | Authors: | Wang, L, Myasnikov, A, Pan, X, Walter, P. | Deposit date: | 2019-06-19 | Release date: | 2020-02-12 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction. Elife, 9, 2020
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6PDY
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![BU of 6pdy by Molmil](/molmil-images/mine/6pdy) | Msp1-substrate complex in open conformation | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | Authors: | Wang, L, Myasnikov, A, Pan, X, Walter, P. | Deposit date: | 2019-06-19 | Release date: | 2020-02-12 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction. Elife, 9, 2020
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6PDW
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![BU of 6pdw by Molmil](/molmil-images/mine/6pdw) | Msp1-substrate complex in closed conformation | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, ... | Authors: | Wang, L, Myasnikov, A, Pan, X, Walter, P. | Deposit date: | 2019-06-19 | Release date: | 2020-02-12 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure of the AAA protein Msp1 reveals mechanism of mislocalized membrane protein extraction. Elife, 9, 2020
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5KN9
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![BU of 5kn9 by Molmil](/molmil-images/mine/5kn9) | MutY N-terminal domain in complex with DNA containing an intrahelical oxoG:A base-pair | Descriptor: | Adenine DNA glycosylase, CALCIUM ION, DNA (5'-D(*AP*GP*CP*AP*CP*AP*GP*GP*AP*T)-3'), ... | Authors: | Wang, L, Chakravarthy, S, Verdine, G.L. | Deposit date: | 2016-06-27 | Release date: | 2017-02-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Structural Basis for the Lesion-scanning Mechanism of the MutY DNA Glycosylase. J. Biol. Chem., 292, 2017
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5KN8
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![BU of 5kn8 by Molmil](/molmil-images/mine/5kn8) | MutY N-terminal domain in complex with undamaged DNA | Descriptor: | Adenine DNA glycosylase, CALCIUM ION, DNA (5'-D(*AP*GP*CP*AP*CP*AP*GP*GP*AP*T)-3'), ... | Authors: | Wang, L, Chakravarthy, S, Verdine, G.L. | Deposit date: | 2016-06-27 | Release date: | 2017-02-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.81 Å) | Cite: | Structural Basis for the Lesion-scanning Mechanism of the MutY DNA Glycosylase. J. Biol. Chem., 292, 2017
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6JFI
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![BU of 6jfi by Molmil](/molmil-images/mine/6jfi) | The symmetric-reconstructed cryo-EM structure of Zika virus-FabZK2B10 complex | Descriptor: | FabZK2B10 heavy chain, FabZK2B10 light chain, ZIKV structural protein E, ... | Authors: | Wang, L, Wang, R.K, Wang, L, Ben, H.J, Yu, L, Gao, F, Shi, X.L, Yin, C.B, Zhang, F.C, Xiang, Y, Zhang, L.Q. | Deposit date: | 2019-02-08 | Release date: | 2019-04-10 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (11 Å) | Cite: | Structural Basis for Neutralization and Protection by a Zika Virus-Specific Human Antibody. Cell Rep, 26, 2019
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6JFH
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![BU of 6jfh by Molmil](/molmil-images/mine/6jfh) | The asymmetric-reconstructed cryo-EM structure of Zika virus-FabZK2B10 complex | Descriptor: | FabZK2B10 heavy chain, FabZK2B10 light chain, ZIKV structural E protein, ... | Authors: | Wang, L, Wang, R.K, Wang, L, Ben, H.J, Yu, L, Gao, F, Shi, X.L, Yin, C.B, Zhang, F.C, Xiang, Y, Zhang, L.Q. | Deposit date: | 2019-02-08 | Release date: | 2019-04-10 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (20 Å) | Cite: | Structural Basis for Neutralization and Protection by a Zika Virus-Specific Human Antibody. Cell Rep, 26, 2019
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6JEP
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![BU of 6jep by Molmil](/molmil-images/mine/6jep) | Structure of a neutralizing antibody bound to the Zika envelope protein domain III | Descriptor: | Genome polyprotein, heavy chain of Fab ZK2B10, light chain of Fab ZK2B10 | Authors: | Wang, L, Wang, R.K, Wang, L, Ben, H.J, Yu, L, Gao, F, Shi, X.L, Yin, C.B, Zhang, F.C, Xiang, Y, Zhang, L.Q. | Deposit date: | 2019-02-07 | Release date: | 2019-05-15 | Last modified: | 2019-05-22 | Method: | X-RAY DIFFRACTION (2.316 Å) | Cite: | Structural Basis for Neutralization and Protection by a Zika Virus-Specific Human Antibody. Cell Rep, 26, 2019
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1MLW
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![BU of 1mlw by Molmil](/molmil-images/mine/1mlw) | Crystal structure of human tryptophan hydroxylase with bound 7,8-dihydro-L-biopterin cofactor and Fe(III) | Descriptor: | 7,8-DIHYDROBIOPTERIN, FE (III) ION, Tryptophan 5-monooxygenase | Authors: | Wang, L, Erlandsen, H, Haavik, J, Knappskog, P.M, Stevens, R.C. | Deposit date: | 2002-08-31 | Release date: | 2002-12-18 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Three-dimensional structure of human tryptophan hydroxylase and its implications for the biosynthesis of the neurotransmitters serotonin and melatonin Biochemistry, 41, 2002
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4GAW
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![BU of 4gaw by Molmil](/molmil-images/mine/4gaw) | Crystal structure of active human granzyme H | Descriptor: | CHLORIDE ION, Granzyme H, SULFATE ION | Authors: | Wang, L, Li, Q, Wu, L, Zhang, K, Tong, L, Sun, F, Fan, Z. | Deposit date: | 2012-07-25 | Release date: | 2013-01-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Identification of SERPINB1 as a physiological inhibitor of human granzyme H J.Immunol., 190, 2013
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4GA7
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![BU of 4ga7 by Molmil](/molmil-images/mine/4ga7) | Crystal structure of human serpinB1 mutant | Descriptor: | Leukocyte elastase inhibitor | Authors: | Wang, L, Li, Q, Wu, L, Zhang, K, Tong, L, Sun, F, Fan, Z. | Deposit date: | 2012-07-25 | Release date: | 2013-01-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Identification of SERPINB1 as a physiological inhibitor of human granzyme H J.Immunol., 190, 2013
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6WM4
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![BU of 6wm4 by Molmil](/molmil-images/mine/6wm4) | Human V-ATPase in state 3 with SidK and ADP | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-DIPHOSPHATE, Renin receptor, ... | Authors: | Wang, L, Wu, H, Fu, T.M. | Deposit date: | 2020-04-20 | Release date: | 2020-11-11 | Last modified: | 2020-11-18 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly. Mol.Cell, 80, 2020
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6WLZ
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![BU of 6wlz by Molmil](/molmil-images/mine/6wlz) | The V1 region of human V-ATPase in state 1 (focused refinement) | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, SidK, V-type proton ATPase catalytic subunit A, ... | Authors: | Wang, L, Wu, H, Fu, T.M. | Deposit date: | 2020-04-20 | Release date: | 2020-11-11 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Structures of a Complete Human V-ATPase Reveal Mechanisms of Its Assembly. Mol.Cell, 80, 2020
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