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5CCA
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BU of 5cca by Molmil
Crystal structure of Mtb toxin
Descriptor: Endoribonuclease MazF3
Authors:Cascio, D, Arbing, M, de Serrano, V, Eisenberg, D, Miallau, L, TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-07-01
Release date:2016-09-07
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of Mtb toxin
To Be Published
4Q0G
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BU of 4q0g by Molmil
Crystal structure of beta subunit of acyl-CoA carboxylase AccD1 from Mycobacterium tuberculosis
Descriptor: GLYCEROL, Probable acetyl-/propionyl-CoA carboxylase (Beta subunit) AccD1
Authors:Bie, H.Y, Yin, J, James, M.N.G, TB Structural Genomics Consortium (TBSGC)
Deposit date:2014-04-02
Release date:2016-04-20
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Crystal structure of Beta subunit of acyl-CoA carboxylase AccD1 from Mycobacterium tuberculosis
To be Published
1VS0
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BU of 1vs0 by Molmil
Crystal Structure of the Ligase Domain from M. tuberculosis LigD at 2.4A
Descriptor: CHLORIDE ION, MAGNESIUM ION, Putative DNA ligase-like protein Rv0938/MT0965, ...
Authors:Akey, D, Martins, A, Aniukwu, J, Glickman, M.S, Shuman, S, Berger, J.M, TB Structural Genomics Consortium (TBSGC)
Deposit date:2006-01-27
Release date:2006-02-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure and Nonhomologous End-joining Function of the Ligase Component of Mycobacterium DNA Ligase D.
J.Biol.Chem., 281, 2006
1HTO
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BU of 1hto by Molmil
CRYSTALLOGRAPHIC STRUCTURE OF A RELAXED GLUTAMINE SYNTHETASE FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor: ADENOSINE MONOPHOSPHATE, CITRIC ACID, GLUTAMINE SYNTHETASE, ...
Authors:Gill, H.S, Eisenberg, D, TB Structural Genomics Consortium (TBSGC)
Deposit date:2001-01-01
Release date:2002-07-24
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Multicopy crystallographic refinement of a relaxed glutamine synthetase from Mycobacterium tuberculosis highlights flexible loops in the enzymatic mechanism and its regulation.
Biochemistry, 41, 2002
1HZP
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BU of 1hzp by Molmil
Crystal Structure of the Myobacterium Tuberculosis Beta-Ketoacyl-Acyl Carrier Protein Synthase III
Descriptor: 3-OXOACYL-[ACYL-CARRIER-PROTEIN] SYNTHASE III, GLYCEROL, LAURIC ACID
Authors:Scarsdale, J.N, Kazanina, G, He, X, Reynolds, K.A, Wright, H.T, TB Structural Genomics Consortium (TBSGC)
Deposit date:2001-01-25
Release date:2001-06-13
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the Mycobacterium tuberculosis beta-ketoacyl-acyl carrier protein synthase III
J.Biol.Chem., 276, 2001
1HX5
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BU of 1hx5 by Molmil
Crystal structure of M. tuberculosis chaperonin-10
Descriptor: 10 KDA CHAPERONIN
Authors:Taneja, B, Mande, S.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2001-01-11
Release date:2001-08-08
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Three-dimensional Structure of Mycobacterium tuberculosis Chaperonin-10 Reveals a Partially Stable Conformation for its Mobile Loop
CURR.SCI., 81, 2001
1I9G
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BU of 1i9g by Molmil
CRYSTAL STRUCTURE OF AN ADOMET DEPENDENT METHYLTRANSFERASE
Descriptor: HYPOTHETICAL PROTEIN RV2118C, S-ADENOSYLMETHIONINE
Authors:Gupta, A, Kumar, P.H, Dineshkumar, T.K, Varshney, U, Subramanya, H.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2001-03-20
Release date:2001-09-26
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Crystal structure of Rv2118c: an AdoMet-dependent methyltransferase from Mycobacterium tuberculosis H37Rv.
J.Mol.Biol., 312, 2001
4XT4
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BU of 4xt4 by Molmil
Crystal structure of Rv2671 from Mycobacteirum tuberculosis in complex with dihydropteridine ring of dihydropteroic acid
Descriptor: 2-amino-6-methyl-7,8-dihydropteridin-4(3H)-one, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Sacchettini, J.C, Cheng, Y.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:2015-01-22
Release date:2016-02-24
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.891 Å)
Cite:Structural Insights into Mycobacterium tuberculosis Rv2671 Protein as a Dihydrofolate Reductase Functional Analogue Contributing to para-Aminosalicylic Acid Resistance.
Biochemistry, 55, 2016
3T40
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BU of 3t40 by Molmil
Crystal Structure of Mycobacterium tuberculosis Indole Glycerol Phosphate Synthase (IGPS) complex with N-2-Carboxyphenyl Glycine (CPG)
Descriptor: 2-[(carboxymethyl)amino]benzoic acid, Indole-3-glycerol phosphate synthase, SULFATE ION
Authors:Reddy, M.C.M, Bruning, J.B, Thurman, C, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2011-07-25
Release date:2012-08-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.752 Å)
Cite:Structural Insights and Inhibition of Mycobacterium tuberculosis Indole Glycerol Phosphate Synthase (IGPS): an Essential Enzyme for Tryptophan Biosynthesis
To be Published
2QKX
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BU of 2qkx by Molmil
N-acetyl glucosamine 1-phosphate uridyltransferase from Mycobacterium tuberculosis complex with N-acetyl glucosamine 1-phosphate
Descriptor: 2-acetamido-2-deoxy-1-O-phosphono-alpha-D-glucopyranose, Bifunctional protein glmU
Authors:Zhang, Z, Squire, C.J, Baker, E.N, TB Structural Genomics Consortium (TBSGC)
Deposit date:2007-07-11
Release date:2008-07-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structure and function of GlmU from Mycobacterium tuberculosis.
Acta Crystallogr.,Sect.D, 65, 2009
2PKF
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BU of 2pkf by Molmil
Crystal structure of M tuberculosis Adenosine Kinase (apo)
Descriptor: Adenosine kinase
Authors:Reddy, M.C.M, Palaninathan, S.K, Shetty, N.D, Owen, J.L, Watson, M.D, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2007-04-17
Release date:2007-06-19
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:High resolution crystal structures of Mycobacterium tuberculosis adenosine kinase: insights into the mechanism and specificity of this novel prokaryotic enzyme
J.Biol.Chem., 282, 2007
4EBN
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BU of 4ebn by Molmil
BlaC Amoxicillin Acyl-Intermediate Complex
Descriptor: 2-{1-[2-AMINO-2-(4-HYDROXY-PHENYL)-ACETYLAMINO]-2-OXO-ETHYL}-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID, Beta-lactamase, PHOSPHATE ION
Authors:Mire, J.A, TB Structural Genomics Consortium (TBSGC)
Deposit date:2012-03-23
Release date:2013-04-03
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Faropenem is Effective Against Mycobacterium tuberculosis in vitro and in vivo
To be Published
4EBL
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BU of 4ebl by Molmil
BlaC E166A Faropenem Acyl-Intermediate Complex
Descriptor: (2R,5R)-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-5-[(2R)-tetrahydrofuran-2-yl]-2,5-dihydro-1,3-thiazole-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION
Authors:Mire, J.A, TB Structural Genomics Consortium (TBSGC)
Deposit date:2012-03-23
Release date:2013-04-03
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Faropenem is Effective Against Mycobacterium tuberculosis in vitro and in vivo
To be Published
4EBP
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BU of 4ebp by Molmil
BlaC E166A Cefotaxime Acyl-Intermediate Complex
Descriptor: Beta-lactamase, CEFOTAXIME, C3' cleaved, ...
Authors:Mire, J.A, TB Structural Genomics Consortium (TBSGC)
Deposit date:2012-03-23
Release date:2013-04-03
Last modified:2024-11-20
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Faropenem is Effective Against Mycobacterium tuberculosis in vitro and in vivo
To be Published
1C3V
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BU of 1c3v by Molmil
DIHYDRODIPICOLINATE REDUCTASE FROM MYCOBACTERIUM TUBERCULOSIS COMPLEXED WITH NADPH AND PDC
Descriptor: DIHYDRODIPICOLINATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, PYRIDINE-2,6-DICARBOXYLIC ACID, ...
Authors:Cirilli, M, Zheng, R, Scapin, G, Blanchard, J.S, TB Structural Genomics Consortium (TBSGC)
Deposit date:1999-07-28
Release date:2003-08-26
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:The three-dimensional structures of the Mycobacterium tuberculosis dihydrodipicolinate reductase-NADH-2,6-PDC and -NADPH-2,6-PDC complexes. Structural and mutagenic analysis of relaxed nucleotide specificity
Biochemistry, 42, 2003
1BVR
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BU of 1bvr by Molmil
M.TB. ENOYL-ACP REDUCTASE (INHA) IN COMPLEX WITH NAD+ AND C16-FATTY-ACYL-SUBSTRATE
Descriptor: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PROTEIN (ENOYL-ACYL CARRIER PROTEIN (ACP) REDUCTASE), TRANS-2-HEXADECENOYL-(N-ACETYL-CYSTEAMINE)-THIOESTER
Authors:Rozwarski, D.A, Vilcheze, C, Sugantino, M, Bittman, R, Jacobs, W, TB Structural Genomics Consortium (TBSGC)
Deposit date:1998-09-17
Release date:1999-09-17
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the Mycobacterium tuberculosis enoyl-ACP reductase, InhA, in complex with NAD+ and a C16 fatty acyl substrate.
J.Biol.Chem., 274, 1999
3BZQ
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BU of 3bzq by Molmil
High resolution crystal structure of Nitrogen Regulatory Protein (Rv2919c) of Mycobacterium tuberculosis
Descriptor: Nitrogen regulatory protein P-II
Authors:Reddy, M.C, Palaninathan, S.K, Shetty, N.D, Owen, J.L, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2008-01-18
Release date:2008-04-01
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structures of the apo and ATP bound Mycobacterium tuberculosis nitrogen regulatory PII protein.
Protein Sci., 19, 2010
3K7Z
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BU of 3k7z by Molmil
GCN4-Leucine zipper core mutant as N16A trigonal automatic solution
Descriptor: General control protein GCN4
Authors:Holton, J, Alber, T, TB Structural Genomics Consortium (TBSGC)
Deposit date:2009-10-13
Release date:2009-11-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Automated Protein Crystal Structure Determination Using Elves.
Proc.Natl.Acad.Sci.USA, 101, 2004
8GKF
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BU of 8gkf by Molmil
Phosphopantetheinyl transferase PptT from Mycobacterium tuberculosis in complex with Raltitrexed.
Descriptor: 4'-phosphopantetheinyl transferase PptT, TOMUDEX
Authors:Krieger, I.V, Singh, A, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2023-03-18
Release date:2024-03-20
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Redirecting raltitrexed from cancer cell thymidylate synthase to Mycobacterium tuberculosis phosphopantetheinyl transferase.
Sci Adv, 10, 2024
7SFR
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BU of 7sfr by Molmil
Unmethylated Mtb Ribosome 50S with SEQ-9
Descriptor: 16S rRNA, 23S rRNA, 30S ribosomal protein S10, ...
Authors:Xing, Z, Cui, Z, Zhang, J, TB Structural Genomics Consortium (TBSGC)
Deposit date:2021-10-04
Release date:2022-10-12
Last modified:2024-06-05
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents.
Cell, 186, 2023
4UAQ
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BU of 4uaq by Molmil
Crystal structure of the accessory translocation ATPase, SecA2, from Mycobacterium tuberculosis
Descriptor: Protein translocase subunit SecA 2
Authors:Swanson-Smith, S, Ioerger, T.R, Rigel, N.W, Miller, B.K, Braunstein, M, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2014-08-11
Release date:2015-09-09
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Similarities and Differences between Two Functionally Distinct SecA Proteins, Mycobacterium tuberculosis SecA1 and SecA2.
J.Bacteriol., 198, 2015
7N8L
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BU of 7n8l by Molmil
PptT PAP(CoA) 9016 complex
Descriptor: 4'-phosphopantetheinyl transferase PptT, COENZYME A, DIMETHYL SULFOXIDE, ...
Authors:Mosior, J.W, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2021-06-15
Release date:2022-02-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas.
J.Med.Chem., 65, 2022
7N8M
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BU of 7n8m by Molmil
PptT PAP(CoA) 8978B complex
Descriptor: 4'-phosphopantetheinyl transferase PptT, COENZYME A, DIMETHYL SULFOXIDE, ...
Authors:Mosior, J.W, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2021-06-15
Release date:2022-02-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas.
J.Med.Chem., 65, 2022
7N8E
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BU of 7n8e by Molmil
PptT PAP(CoA) 9056 complex
Descriptor: 4'-phosphopantetheinyl transferase PptT, COENZYME A, DIMETHYL SULFOXIDE, ...
Authors:Mosior, J.W, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2021-06-14
Release date:2022-02-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:In Vitro and In Vivo Inhibition of the Mycobacterium tuberculosis Phosphopantetheinyl Transferase PptT by Amidinoureas.
J.Med.Chem., 65, 2022
5KVU
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BU of 5kvu by Molmil
Crystal structure of isocitrate dehydrogenase-2 in complex with NADP(+) from Mycobacterium tuberculosis
Descriptor: 1,2-ETHANEDIOL, D-MALATE, GLYCEROL, ...
Authors:Cheng, Y.S, Sacchettini, J.C, TB Structural Genomics Consortium (TBSGC)
Deposit date:2016-07-15
Release date:2017-07-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Structural and kinetic characterization of isocitrate dehydrogenase-2 from Mycobacterium tuberculosis
To Be Published

227561

数据于2024-11-20公开中

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