Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDBDonate
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
2Z59
DownloadVisualize
BU of 2z59 by Molmil
Complex Structures of Mouse Rpn13 (22-130aa) and ubiquitin
Descriptor: Protein ADRM1, Ubiquitin
Authors:Chen, X, Schreiner, P, Groll, M, Walters, K.J.
Deposit date:2007-07-01
Release date:2008-05-20
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction.
Nature, 453, 2008
6Y0F
DownloadVisualize
BU of 6y0f by Molmil
Structure of human FAPalpha in complex with linagliptin
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-d ione, ...
Authors:Nar, H, Schnapp, G, Schreiner, P.
Deposit date:2020-02-07
Release date:2021-02-17
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.924 Å)
Cite:Structure of human FAPalpha in complex with linagliptin
To Be Published
3PLS
DownloadVisualize
BU of 3pls by Molmil
RON in complex with ligand AMP-PNP
Descriptor: MAGNESIUM ION, Macrophage-stimulating protein receptor, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Wang, J, Steinbacher, S, Augustin, M, Schreiner, P, Epstein, D, Mulvihill, M.J, Crew, A.P.
Deposit date:2010-11-15
Release date:2010-11-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:The Crystal Structure of a Constitutively Active Mutant RON Kinase Suggests an Intramolecular Autophosphorylation Hypothesis
Biochemistry, 49, 2010
5BYY
DownloadVisualize
BU of 5byy by Molmil
ERK5 IN COMPLEX WITH SMALL MOLECULE
Descriptor: 2-{[2-ethoxy-4-(4-hydroxypiperidin-1-yl)phenyl]amino}-5,11-dimethyl-5,11-dihydro-6H-pyrimido[4,5-b][1,4]benzodiazepin-6-one, Mitogen-activated protein kinase 7
Authors:Chen, H, Tucker, J, Wang, X, Gavine, P.R, Philips, C, Augustin, M.A, Schreiner, P, Steinbacher, S, Preston, M, Ogg, D.
Deposit date:2015-06-11
Release date:2016-05-04
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.79 Å)
Cite:Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site.
Acta Crystallogr D Struct Biol, 72, 2016
5BYZ
DownloadVisualize
BU of 5byz by Molmil
ERK5 in complex with small molecule
Descriptor: 4-({5-fluoro-4-[2-methyl-1-(propan-2-yl)-1H-imidazol-5-yl]pyrimidin-2-yl}amino)-N-[2-(piperidin-1-yl)ethyl]benzamide, GLYCEROL, Mitogen-activated protein kinase 7
Authors:Chen, H, Tucker, J, Wang, X, Gavine, P.R, Philips, C, Augustin, M.A, Schreiner, P, Steinbacher, S, Preston, M, Ogg, D.
Deposit date:2015-06-11
Release date:2016-05-04
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site.
Acta Crystallogr D Struct Biol, 72, 2016
2R2Y
DownloadVisualize
BU of 2r2y by Molmil
Crystal structure of the proteasomal Rpn13 PRU-domain
Descriptor: Protein ADRM1
Authors:Groll, M, Walters, K, Dikic, I, Finley, D.
Deposit date:2007-08-28
Release date:2008-05-13
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction.
Nature, 453, 2008
4DFN
DownloadVisualize
BU of 4dfn by Molmil
Crystal structure of spleen tyrosine kinase complexed with an adamantylpyrazine inhibitor
Descriptor: 3-amino-6-[3-(1-methyl-1H-pyrazol-4-yl)phenyl]-N-[(1R,2r,3S,5s,7s)-5-hydroxyadamantan-2-yl]pyrazine-2-carboxamide, Tyrosine-protein kinase SYK
Authors:Lopez, M, Segarra, V, Vidal, B, Wenzkowski, C, Jestel, A, Krapp, S, Blaesse, M, Nagel, S, Schreiner, P.
Deposit date:2012-01-24
Release date:2012-04-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Pyrazine-based Syk kinase inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
4F4P
DownloadVisualize
BU of 4f4p by Molmil
SYK in COMPLEX WITH LIGAND LASW836
Descriptor: N-{6-[3-(piperazin-1-yl)phenyl]pyridin-2-yl}-4-(trifluoromethyl)pyridin-2-amine, SULFATE ION, Tyrosine-protein kinase SYK
Authors:Lopez, M, Segarra, V, Vidal, B, Wenzkowski, C, Jestel, A, Krapp, S, Blaesse, M, Nagel, S, Schreiner, P.
Deposit date:2012-05-11
Release date:2012-12-12
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Highly potent aminopyridines as Syk kinase inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
4ZSG
DownloadVisualize
BU of 4zsg by Molmil
MITOGEN ACTIVATED PROTEIN KINASE 7 IN COMPLEX WITH INHIBITOR
Descriptor: 3-amino-5-[(4-chlorophenyl)amino]-N-(propan-2-yl)-1H-1,2,4-triazole-1-carboxamide, GLYCEROL, Mitogen-activated protein kinase 7
Authors:Tucker, J, Ogg, D.J.
Deposit date:2015-05-13
Release date:2016-05-04
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site.
Acta Crystallogr D Struct Biol, 72, 2016
4ZSJ
DownloadVisualize
BU of 4zsj by Molmil
MITOGEN ACTIVATED PROTEIN KINASE 7 IN COMPLEX WITH INHIBITOR
Descriptor: 3-amino-5-[(4-chloro-3-methylphenyl)amino]-N-(propan-2-yl)-1H-1,2,4-triazole-1-carboxamide, GLYCEROL, Mitogen-activated protein kinase 7
Authors:Tucker, J, Ogg, D.J.
Deposit date:2015-05-13
Release date:2016-05-04
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site.
Acta Crystallogr D Struct Biol, 72, 2016
4DFL
DownloadVisualize
BU of 4dfl by Molmil
Crystal structure of spleen tyrosine kinase complexed with a sulfonamidopyrazine piperidine inhibitor
Descriptor: 1,2-ETHANEDIOL, 3-amino-6-{3-[(methylsulfonyl)amino]phenyl}-N-(piperidin-4-ylmethyl)pyrazine-2-carboxamide, SULFATE ION, ...
Authors:Lopez, M, Segarra, V, Vidal, B, Wenzkowski, C, Jestel, A, Krapp, S, Blaesse, M, Nagel, S, Schreiner, P.
Deposit date:2012-01-24
Release date:2012-04-25
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Pyrazine-based Syk kinase inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
4ZSL
DownloadVisualize
BU of 4zsl by Molmil
MITOGEN ACTIVATED PROTEIN KINASE 7 IN COMPLEX WITH INHIBITOR
Descriptor: 3-amino-5-[(4-chlorophenyl)amino]-N-[(1S)-1-phenylethyl]-1H-1,2,4-triazole-1-carboxamide, GLYCEROL, Mitogen-activated protein kinase 7
Authors:Ogg, D.J, Tucker, J.
Deposit date:2015-05-13
Release date:2016-05-04
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site.
Acta Crystallogr D Struct Biol, 72, 2016

229183

数据于2024-12-18公开中

PDB statisticsPDBj update infoContact PDBjnumon