4ZSL

MITOGEN ACTIVATED PROTEIN KINASE 7 IN COMPLEX WITH INHIBITOR

Summary for 4ZSL

• Entry DOI: 10.2210/pdb4zsl/pdb
• Related: 4ZSG
• Descriptor: Mitogen-activated protein kinase 7, 3-amino-5-[(4-chlorophenyl)amino]-N-[(1S)-1-phenylethyl]-1H-1,2,4-triazole-1-carboxamide, GLYCEROL, ... (4 entities in total)
• Functional Keywords: kinase, inhibitor, transferase
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: Q13164
• Total number of polymer chains: 1
• Total formula weight: 39954.38

Authors

Ogg, D.J.,Tucker, J. (deposition date: 2015-05-13, release date: 2016-05-04, Last modification date: 2016-05-11)

• Primary citation: Chen, H.,Tucker, J.,Wang, X.,Gavine, P.R.,Phillips, C.,Augustin, M.A.,Schreiner, P.,Steinbacher, S.,Preston, M.,Ogg, D.; Discovery of a novel allosteric inhibitor-binding site in ERK5: comparison with the canonical kinase hinge ATP-binding site.; Acta Crystallogr D Struct Biol, 72:682-693, 2016; PubMed: 27139631; DOI: 10.1107/S2059798316004502

Experimental method

X-RAY DIFFRACTION (2.25 Å)