1ZVJ
 
 | | Structure of Kumamolisin-AS mutant, D164N | | Descriptor: | CALCIUM ION, SULFATE ION, kumamolisin-As | | Authors: | Li, M, Wlodawer, A, Gustchina, A, Nakayama, T. | | Deposit date: | 2005-06-02 | | Release date: | 2006-05-23 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Processing, catalytic activity and crystal structures of kumamolisin-As with an engineered active site.
Febs J., 273, 2006
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8VSD
 | | avb8/L-TGF-b1/GARP | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Jin, M, Cheng, Y, Nishimura, S.L. | | Deposit date: | 2024-01-23 | | Release date: | 2024-09-11 | | Last modified: | 2024-10-02 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Dynamic allostery drives autocrine and paracrine TGF-beta signaling.
Cell, 2024
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8VS6
 | | L-TGF-b3/avb8 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Jin, M, Cheng, Y, Nishimura, S.L. | | Deposit date: | 2024-01-23 | | Release date: | 2024-09-11 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (2.73 Å) | | Cite: | Dynamic allostery drives autocrine and paracrine TGF-beta signaling.
Cell, 2024
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8VSC
 | | L-TGF-b1/GARP | | Descriptor: | Transforming growth factor beta activator LRRC32, Transforming growth factor beta-1 proprotein | | Authors: | Jin, M, Cheng, Y, Nishimura, S.L. | | Deposit date: | 2024-01-23 | | Release date: | 2024-09-11 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Dynamic allostery drives autocrine and paracrine TGF-beta signaling.
Cell, 2024
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8VSB
 | | L-TGF-b3/GARP | | Descriptor: | Transforming growth factor beta activator LRRC32, Transforming growth factor beta-3 proprotein | | Authors: | Jin, M, Cheng, Y, Nishimura, S.L. | | Deposit date: | 2024-01-23 | | Release date: | 2024-09-11 | | Last modified: | 2024-10-02 | | Method: | ELECTRON MICROSCOPY (2.93 Å) | | Cite: | Dynamic allostery drives autocrine and paracrine TGF-beta signaling.
Cell, 2024
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2NSQ
 | | Crystal structure of the C2 domain of the human E3 ubiquitin-protein ligase NEDD4-like protein | | Descriptor: | 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase NEDD4-like protein, GLYCEROL | | Authors: | Walker, J.R, Avvakumov, G.V, Xue, S, Butler-Cole, C, Finerty Jr, P.J, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | | Deposit date: | 2006-11-06 | | Release date: | 2006-12-19 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | The C2 domain of the human E3 ubiquitin-protein ligase NEDD4-like protein
To be Published
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3NLA
 | | NMR STRUCTURE OF THE N-TERMINAL DOMAIN WITH A LINKER PORTION OF ANTARCTIC EEL POUT ANTIFREEZE PROTEIN RD3, 40 STRUCTURES | | Descriptor: | ANTIFREEZE PROTEIN RD3 TYPE III | | Authors: | Miura, K, Ohgiya, S, Hoshino, T, Nemoto, N, Hikichi, K, Tsuda, S. | | Deposit date: | 1998-02-24 | | Release date: | 1999-02-23 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Structural basis for the binding of a globular antifreeze protein to ice.
Nature, 384, 1996
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5YO8
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2EI6
 | | FACTOR XA IN COMPLEX WITH THE INHIBITOR (-)-cis-N1-[(5-Chloroindol-2-yl)carbonyl]-N2-[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine | | Descriptor: | CALCIUM ION, Coagulation factor X, heavy chain, ... | | Authors: | Suzuki, M. | | Deposit date: | 2007-03-12 | | Release date: | 2008-03-18 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Cycloalkanediamine derivatives as novel blood coagulation factor Xa inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
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2EI7
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4ONC
 | | Crystal Structure of Mycobacterium Tuberculosis Decaprenyl Diphosphate Synthase in Complex with BPH-640 | | Descriptor: | Decaprenyl diphosphate synthase, [hydroxy(1,1':3',1''-terphenyl-3-yl)methanediyl]bis(phosphonic acid) | | Authors: | Feng, X, Chan, H.C, Ko, T.P. | | Deposit date: | 2014-01-28 | | Release date: | 2014-04-02 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.83 Å) | | Cite: | Structure and Inhibition of Tuberculosinol Synthase and Decaprenyl Diphosphate Synthase from Mycobacterium tuberculosis
J.Am.Chem.Soc., 136, 2014
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7DDM
 | | Crystal Structure of PenA39 beta-Lactamase | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ALA-ALA-ARG-ASP-ALA-ALA-VAL-SER-ASP-ALA-ALA-ALA, ... | | Authors: | Nukaga, M, Hoshino, T, Papp-Wallace, K.M. | | Deposit date: | 2020-10-29 | | Release date: | 2021-11-03 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | Frameshift mutations in genes encoding PBP3 and PBP4 trigger an unusual, extreme beta-lactam resistance phenotype in Burkholderia multivorans
To Be Published
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3A6V
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2E1U
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3A6T
 | | Crystal structure of MutT-8-OXO-DGMP complex | | Descriptor: | 8-OXO-2'-DEOXY-GUANOSINE-5'-MONOPHOSPHATE, Mutator mutT protein, SODIUM ION, ... | | Authors: | Nakamura, T, Yamagata, Y. | | Deposit date: | 2009-09-09 | | Release date: | 2009-10-27 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.96 Å) | | Cite: | Structural and dynamic features of the MutT protein in the recognition of nucleotides with the mutagenic 8-oxoguanine base
J.Biol.Chem., 285, 2010
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2E1V
 | | Crystal structure of Dendranthema morifolium DmAT, seleno-methionine derivative | | Descriptor: | acyl transferase | | Authors: | Unno, H, Ichimaida, F, Kusunoki, M, Nakayama, T. | | Deposit date: | 2006-10-28 | | Release date: | 2007-04-10 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural and Mutational Studies of Anthocyanin Malonyltransferases Establish the Features of BAHD Enzyme Catalysis
J.Biol.Chem., 282, 2007
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3A6S
 | | Crystal structure of the MutT protein | | Descriptor: | L(+)-TARTARIC ACID, Mutator mutT protein, SODIUM ION | | Authors: | Nakamura, T, Yamagata, Y. | | Deposit date: | 2009-09-09 | | Release date: | 2009-10-27 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural and dynamic features of the MutT protein in the recognition of nucleotides with the mutagenic 8-oxoguanine base
J.Biol.Chem., 285, 2010
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3RDN
 | | NMR STRUCTURE OF THE N-TERMINAL DOMAIN WITH A LINKER PORTION OF ANTARCTIC EEL POUT ANTIFREEZE PROTEIN RD3, MINIMIZED AVERAGE STRUCTURE | | Descriptor: | ANTIFREEZE PROTEIN RD3 TYPE III | | Authors: | Miura, K, Ohgiya, S, Hoshino, T, Nemoto, N, Hikichi, K, Tsuda, S. | | Deposit date: | 1998-02-24 | | Release date: | 1999-02-23 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Structural basis for the binding of a globular antifreeze protein to ice.
Nature, 384, 1996
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4QCI
 | | PDGF-B blocking antibody bound to PDGF-BB | | Descriptor: | Platelet-derived growth factor subunit B, anti-PDGF-BB antibody - Light Chain, anti-PDGF-BB antibody - Heavy chain | | Authors: | Kuai, J, Mosyak, L, Tam, M, LaVallie, E, Pullen, N, Carven, G. | | Deposit date: | 2014-05-12 | | Release date: | 2015-03-11 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Characterization of Binding Mode of Action of a Blocking Anti-Platelet-Derived Growth Factor (PDGF)-B Monoclonal Antibody, MOR8457, Reveals Conformational Flexibility and Avidity Needed for PDGF-BB To Bind PDGF Receptor-beta.
Biochemistry, 54, 2015
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3W5E
 | | Crystal structure of phosphodiesterase 4B in complex with compound 31e | | Descriptor: | CALCIUM ION, N-tert-butyl-2-{4-[(5,5-dioxido-2-phenyl-7,8-dihydro-6H-thiopyrano[3,2-d]pyrimidin-4-yl)amino]phenyl}acetamide, ZINC ION, ... | | Authors: | Takahashi, M, Hanzawa, H. | | Deposit date: | 2013-01-28 | | Release date: | 2013-05-29 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Identification of the fused bicyclic 4-amino-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors
Bioorg.Med.Chem.Lett., 23, 2013
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3WD9
 | | Crystal structure of phosphodiesterase 4B in complex with compound 10f | | Descriptor: | 4-[(4-{2-[(2,2-dimethylpropyl)amino]-2-oxoethyl}phenyl)amino]-2-phenylpyrimidine-5-carboxamide, CALCIUM ION, ZINC ION, ... | | Authors: | Takahashi, M, Hanzawa, H. | | Deposit date: | 2013-06-11 | | Release date: | 2013-10-23 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Synthesis and biological evaluation of 5-carbamoyl-2-phenylpyrimidine derivatives as novel and potent PDE4 inhibitors
Bioorg.Med.Chem., 21, 2013
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3A6U
 | | Crystal structure of MutT-8-OXO-dGMP-MN(II) complex | | Descriptor: | 8-OXO-2'-DEOXY-GUANOSINE-5'-MONOPHOSPHATE, MANGANESE (II) ION, Mutator mutT protein, ... | | Authors: | Nakamura, T, Yamagata, Y. | | Deposit date: | 2009-09-09 | | Release date: | 2009-10-27 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.56 Å) | | Cite: | Structural and dynamic features of the MutT protein in the recognition of nucleotides with the mutagenic 8-oxoguanine base
J.Biol.Chem., 285, 2010
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2E1T
 | | Crystal structure of Dendranthema morifolium DmAT complexed with malonyl-CoA | | Descriptor: | MALONYL-COENZYME A, acyl transferase | | Authors: | Unno, H, Ichimaida, F, Kusunoki, M, Nakayama, T. | | Deposit date: | 2006-10-28 | | Release date: | 2007-04-10 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structural and Mutational Studies of Anthocyanin Malonyltransferases Establish the Features of BAHD Enzyme Catalysis
J.Biol.Chem., 282, 2007
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3GGU
 | | HIV PR drug resistant patient's variant in complex with darunavir | | Descriptor: | (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, Protease | | Authors: | Saskova, K.G, Brynda, J, Rezacova, P. | | Deposit date: | 2009-03-02 | | Release date: | 2009-08-11 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Molecular characterization of clinical isolates of human immunodeficiency virus resistant to the protease inhibitor darunavir.
J.Virol., 83, 2009
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2EI8
 | | FACTOR XA IN COMPLEX WITH THE INHIBITOR (1S,2R,4S)-N1-[(5-chloroindol-2-yl)carbonyl]-4-(N,N-dimethylcarbamoyl)-N2-[(5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridin-2-yl)carbonyl]-1,2-cyclohexanediamine | | Descriptor: | CALCIUM ION, Coagulation factor X, heavy chain, ... | | Authors: | Suzuki, M. | | Deposit date: | 2007-03-12 | | Release date: | 2008-03-18 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Discovery of N-{(1R,2S,5S)-2-{[(5-Chloroindol-2-yl)carbonyl]amino}-5-[(dimethylamino)carbonyl]cyclohexyl}-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide hydrochloride: A Novel, Potent and Orally Active Direct Inhibitor of Factor Xa
To be Published
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