7PSE
| Crystal Structure of a Class D Carbapenemase_K73ALY Complexed with Oxacillin | Descriptor: | (2R,4S)-5,5-dimethyl-2-[(1R)-1-{[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino}-2-oxoethyl]-1,3-thiazolidine-4-carb oxylic acid, 1-BUTANOL, Beta-lactamase, ... | Authors: | Zhou, Q, He, Y, Jin, Y. | Deposit date: | 2021-09-23 | Release date: | 2022-10-05 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | An Ion-Pair Induced Intermediate Complex Captured in Class D Carbapenemase Reveals Chloride Ion as a Janus Effector Modulating Activity Acs Cent.Sci., 2023
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4PZV
| Crystal structure of Francisella tularensis HPPK-DHPS in complex with bisubstrate analog HPPK inhibitor J1D | Descriptor: | 1,2-ETHANEDIOL, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase/dihydropteroate synthase, 5'-{[2-({N-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)carbonyl]glycyl}amino)ethyl]sulfonyl}-5'-deoxyadenosine | Authors: | Shaw, G.X, Shi, G, Ji, X. | Deposit date: | 2014-03-31 | Release date: | 2014-07-16 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.704 Å) | Cite: | Structural enzymology and inhibition of the bi-functional folate pathway enzyme HPPK-DHPS from the biowarfare agent Francisella tularensis. Febs J., 281, 2014
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3NOK
| Crystal structure of Myxococcus xanthus Glutaminyl Cyclase | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, DECYLAMINE-N,N-DIMETHYL-N-OXIDE, ... | Authors: | Parthier, C, Carrillo, D.R, Stubbs, M.T. | Deposit date: | 2010-06-25 | Release date: | 2010-11-03 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Kinetic and structural characterization of bacterial glutaminyl cyclases from Zymomonas mobilis and Myxococcus xanthus Biol.Chem., 391, 2010
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7Q14
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3S88
| Crystal structure of Sudan Ebolavirus Glycoprotein (strain Gulu) bound to 16F6 | Descriptor: | 16F6 - Heavy chain, 16F6 - Light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Saphire, E.O, Dias, J.M, Bale, S. | Deposit date: | 2011-05-27 | Release date: | 2011-12-07 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.351 Å) | Cite: | A shared structural solution for neutralizing ebolaviruses. Nat.Struct.Mol.Biol., 18, 2011
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3NOM
| Crystal Structure of Zymomonas mobilis Glutaminyl Cyclase (monoclinic form) | Descriptor: | CALCIUM ION, GLYCEROL, Glutamine cyclotransferase, ... | Authors: | Parthier, C, Carrillo, D.R, Stubbs, M.T. | Deposit date: | 2010-06-25 | Release date: | 2010-11-03 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Kinetic and structural characterization of bacterial glutaminyl cyclases from Zymomonas mobilis and Myxococcus xanthus Biol.Chem., 391, 2010
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7PGO
| Crystal Structure of a Class D Carbapenemase_R250A | Descriptor: | 1-BUTANOL, BROMIDE ION, Beta-lactamase | Authors: | Zhou, Q, He, Y, Jin, Y. | Deposit date: | 2021-08-15 | Release date: | 2022-08-24 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | An Ion-Pair Induced Intermediate Complex Captured in Class D Carbapenemase Reveals Chloride Ion as a Janus Effector Modulating Activity Acs Cent.Sci., 2023
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7R75
| Structure of human SHP2 in complex with compound 16 | Descriptor: | 6-(4-amino-4-methylpiperidin-1-yl)-3-(3-chlorophenyl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Leonard, P.G, Cross, J. | Deposit date: | 2021-06-24 | Release date: | 2021-10-27 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | Discovery of 6-[(3 S ,4 S )-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor. J.Med.Chem., 64, 2021
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7R7D
| Structure of human SHP2 in complex with compound 22 | Descriptor: | 4-[6-(4-amino-4-methylpiperidin-1-yl)-1H-pyrazolo[3,4-b]pyrazin-3-yl]-3-chloro-N-methylpyridin-2-amine, TETRAETHYLENE GLYCOL, Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Leonard, P.G, Cross, J. | Deposit date: | 2021-06-24 | Release date: | 2021-10-27 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Discovery of 6-[(3 S ,4 S )-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor. J.Med.Chem., 64, 2021
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7R7L
| Structure of human SHP2 in complex with compound 30 | Descriptor: | 6-[(3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methylpyrimidin-4(3H)-one, Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Leonard, P.G, Cross, J. | Deposit date: | 2021-06-24 | Release date: | 2021-10-27 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Discovery of 6-[(3 S ,4 S )-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor. J.Med.Chem., 64, 2021
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7R7I
| Structure of human SHP2 in complex with compound 27 | Descriptor: | Tyrosine-protein phosphatase non-receptor type 11, [3-(4-amino-4-methylpiperidin-1-yl)-6-(2,3-dichlorophenyl)-5-methylpyrazin-2-yl]methanol | Authors: | Leonard, P.G, Cross, J. | Deposit date: | 2021-06-24 | Release date: | 2021-10-27 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Discovery of 6-[(3 S ,4 S )-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor. J.Med.Chem., 64, 2021
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3N9J
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8R80
| SARS-CoV-2 Delta RBD in complex with XBB-9 Fab and an anti-Fab nanobody | Descriptor: | Spike protein S1, XBB-9 Fab heavy chain, XBB-9 Fab light chain, ... | Authors: | Zhou, D, Ren, J, Stuart, D.I. | Deposit date: | 2023-11-27 | Release date: | 2024-05-08 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (4.03 Å) | Cite: | A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity. Cell Rep Med, 5, 2024
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8QRF
| SARS-CoV-2 delta RBD complexed with XBB-6 and beta-49 Fabs | Descriptor: | Beta-49 heavy chain, Beta-49 light chain, Spike protein S1, ... | Authors: | Zhou, D, Ren, J, Stuart, D.I. | Deposit date: | 2023-10-06 | Release date: | 2024-05-08 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity. Cell Rep Med, 5, 2024
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8QTD
| Local refinement of SARS-CoV-2 BA.2.86 Spike and XBB-7 Fab | Descriptor: | Spike glycoprotein,Fibritin, XBB-7 fab heavy chain, XBB-7 fab light chain | Authors: | Ren, J, Duyvesteyn, H.M.E, Stuart, D.I. | Deposit date: | 2023-10-12 | Release date: | 2024-05-08 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity. Cell Rep Med, 5, 2024
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8QRG
| SARS-CoV-2 delta RBD complexed with XBB-2 Fab and NbC1 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, NbC1, ... | Authors: | Zhou, D, Ren, J, Stuart, D.I. | Deposit date: | 2023-10-07 | Release date: | 2024-05-08 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity. Cell Rep Med, 5, 2024
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8QSQ
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8R8K
| XBB-4 Fab in complex with SARS-CoV-2 BA.2.12.1 Spike Glycoprotein | Descriptor: | Spike glycoprotein,Fibritin, XBB-4 Fab Heavy chain, XBB-4 Fab Light chain | Authors: | Duyvesteyn, H.M.E, Ren, J, Stuart, D.I. | Deposit date: | 2023-11-29 | Release date: | 2024-05-08 | Last modified: | 2024-08-14 | Method: | ELECTRON MICROSCOPY (3.41 Å) | Cite: | A structure-function analysis shows SARS-CoV-2 BA.2.86 balances antibody escape and ACE2 affinity. Cell Rep Med, 5, 2024
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7U97
| SAAV pH 4.0 capsid structure | Descriptor: | Capsid protein | Authors: | Mietzsch, M, McKenna, R. | Deposit date: | 2022-03-10 | Release date: | 2022-04-13 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (2.66 Å) | Cite: | Characterization of the Serpentine Adeno-Associated Virus (SAAV) Capsid Structure: Receptor Interactions and Antigenicity. J.Virol., 96, 2022
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7U95
| SAAV pH 6.0 capsid structure | Descriptor: | Capsid protein | Authors: | Mietzsch, M, McKenna, R. | Deposit date: | 2022-03-10 | Release date: | 2022-04-13 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (2.73 Å) | Cite: | Characterization of the Serpentine Adeno-Associated Virus (SAAV) Capsid Structure: Receptor Interactions and Antigenicity. J.Virol., 96, 2022
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7U96
| SAAV pH 5.5 capsid structure | Descriptor: | Capsid protein | Authors: | Mietzsch, M, McKenna, R. | Deposit date: | 2022-03-10 | Release date: | 2022-04-13 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (2.14 Å) | Cite: | Characterization of the Serpentine Adeno-Associated Virus (SAAV) Capsid Structure: Receptor Interactions and Antigenicity. J.Virol., 96, 2022
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7U94
| SAAV pH 7.4 capsid structure | Descriptor: | Capsid protein | Authors: | Mietzsch, M, McKenna, R. | Deposit date: | 2022-03-10 | Release date: | 2022-04-13 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Characterization of the Serpentine Adeno-Associated Virus (SAAV) Capsid Structure: Receptor Interactions and Antigenicity. J.Virol., 96, 2022
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2WZR
| The Structure of Foot and Mouth Disease Virus Serotype SAT1 | Descriptor: | POLYPROTEIN | Authors: | Adams, P, Lea, S, Newman, J, Blakemore, W, King, A, Stuart, D, Fry, E. | Deposit date: | 2009-12-02 | Release date: | 2010-12-08 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The Structure of Foot-and-Mouth Disease Virus Serotype Sat1. To be Published
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1QUZ
| Solution structure of the potassium channel scorpion toxin HSTX1 | Descriptor: | HSTX1 TOXIN | Authors: | Savarin, P, Romi-Lebrun, R, Zinn-Justin, S, Lebrun, B, Nakajima, T, Gilquin, B, Menez, A. | Deposit date: | 1999-07-05 | Release date: | 2000-07-07 | Last modified: | 2022-03-02 | Method: | SOLUTION NMR | Cite: | Structural and functional consequences of the presence of a fourth disulfide bridge in the scorpion short toxins: solution structure of the potassium channel inhibitor HsTX1. Protein Sci., 8, 1999
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3OKI
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