4QME
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![BU of 4qme by Molmil](/molmil-images/mine/4qme) | Crystal structure of Aminopeptidase N in complex with the phosphinic dipeptide analogue LL-(R,S)-hPheP[CH2]Phe | Descriptor: | (2S)-3-[(S)-[(1R)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]-2-benzylpropanoic acid, Aminopeptidase N, GLYCEROL, ... | Authors: | Nocek, B, Vassilious, S, Mulligan, R, Berlicki, L, Mucha, A, Joachimiak, A. | Deposit date: | 2014-06-16 | Release date: | 2014-10-01 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.601 Å) | Cite: | Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases. J.Med.Chem., 57, 2014
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4QN8
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![BU of 4qn8 by Molmil](/molmil-images/mine/4qn8) | The crystal structure of an effector protein VipE from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 | Descriptor: | BETA-MERCAPTOETHANOL, VipE | Authors: | Tan, K, Xu, X, Cui, H, Liu, S, Savchenko, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2014-06-17 | Release date: | 2014-07-16 | Method: | X-RAY DIFFRACTION (1.751 Å) | Cite: | The crystal structure of an effector protein VipE from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 To be Published
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4QUO
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![BU of 4quo by Molmil](/molmil-images/mine/4quo) | Crystal structure of Aminopeptidase N in complex with the phosphinic dipeptide analogue LL-(R,S)-hPheP[CH2]Phe(3-CH2NH2) | Descriptor: | (2S)-2-[3-(aminomethyl)benzyl]-3-[(R)-[(1R)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]propanoic acid, Aminopeptidase N, GLYCEROL, ... | Authors: | Nocek, B, Mulligan, R, Joachimiak, A, Vassiliou, S, Berlicki, L, Mucha, A. | Deposit date: | 2014-07-11 | Release date: | 2014-09-10 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases. J.Med.Chem., 57, 2014
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4R0J
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![BU of 4r0j by Molmil](/molmil-images/mine/4r0j) | The crystal structure of a functionally uncharacterized protein SMU1763c from Streptococcus mutans | Descriptor: | CHLORIDE ION, SULFATE ION, Uncharacterized protein | Authors: | Tan, K, Xu, X, Cui, H, Liu, S, Savchenko, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2014-07-31 | Release date: | 2014-08-13 | Method: | X-RAY DIFFRACTION (1.715 Å) | Cite: | The crystal structure of a functionally uncharacterized protein SMU1763c from Streptococcus mutans To be Published
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4RD8
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![BU of 4rd8 by Molmil](/molmil-images/mine/4rd8) | The crystal structure of a functionally-unknown protein from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 | Descriptor: | Uncharacterized protein | Authors: | Tan, K, Xu, X, Cui, H, Savchenko, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2014-09-18 | Release date: | 2014-10-01 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | The crystal structure of a functionally-unknown protein from Legionella pneumophila subsp. pneumophila str. Philadelphia 1 To be Published
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4RHA
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![BU of 4rha by Molmil](/molmil-images/mine/4rha) | Structure of the C-terminal domain of outer-membrane protein OmpA from Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETIC ACID, Outer membrane protein A, ... | Authors: | Cuff, M.E, Skarina, T, Savchenko, A, Edwards, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2014-10-01 | Release date: | 2014-10-29 | Last modified: | 2019-12-04 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Insights into PG-binding, conformational change, and dimerization of the OmpA C-terminal domains from Salmonella enterica serovar Typhimurium and Borrelia burgdorferi. Protein Sci., 26, 2017
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4PU2
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![BU of 4pu2 by Molmil](/molmil-images/mine/4pu2) | Crystal structure of Aminopeptidase N in complex with the phosphonic acid analogue of leucine L-(R)-LeuP | Descriptor: | Aminopeptidase N, GLYCEROL, LEUCINE PHOSPHONIC ACID, ... | Authors: | Nocek, B, Vassiliou, S, Berlicki, L, Mulligan, R, Mucha, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2014-03-11 | Release date: | 2014-06-25 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.095 Å) | Cite: | Crystal structure of Aminopeptidase N in complex with the phosphonic acid analogue of leucine To be Published
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2PEV
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![BU of 2pev by Molmil](/molmil-images/mine/2pev) | Complex of Aldose Reductase with NADP+ and simaltaneously bound competetive inhibitors Fidarestat and IDD594. Concentration of Fidarestat in soaking solution exceeds concentration of IDD594. | Descriptor: | (2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE, Aldose reductase, CHLORIDE ION, ... | Authors: | Petrova, T, Hazemann, I, Cousido, A, Mitschler, A, Ginell, S, Joachimiak, A, Podjarny, A. | Deposit date: | 2007-04-03 | Release date: | 2007-04-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (0.9 Å) | Cite: | Crystal packing modifies ligand binding affinity: The case of aldose reductase. Proteins, 80, 2012
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2PFH
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![BU of 2pfh by Molmil](/molmil-images/mine/2pfh) | Complex of Aldose Reductase with NADP+ and simaltaneously bound competetive inhibitors Fidarestat and IDD594. Concentration of Fidarestat in soaking solution is less than concentration of IDD594. | Descriptor: | (2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE, Aldose reductase, CHLORIDE ION, ... | Authors: | Petrova, T, Hazemann, I, Cousido, A, Mitschler, A, Ginell, S, Joachimiak, A, Podjarny, A. | Deposit date: | 2007-04-05 | Release date: | 2007-04-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (0.85 Å) | Cite: | Crystal packing modifies ligand binding affinity: The case of aldose reductase. Proteins, 80, 2012
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2PF8
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![BU of 2pf8 by Molmil](/molmil-images/mine/2pf8) | Complex of Aldose Reductase with NADP+ and simaltaneously bound competetive inhibitors Fidarestat and IDD594. Concentration of Fidarestat in soaking solution is equal to concentration of IDD594. | Descriptor: | (2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE, Aldose reductase, CHLORIDE ION, ... | Authors: | Petrova, T, Hazemann, I, Cousido, A, Mitschler, A, Ginell, S, Joachimiak, A, Podjarny, A. | Deposit date: | 2007-04-04 | Release date: | 2007-04-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (0.85 Å) | Cite: | Crystal packing modifies ligand binding affinity: The case of aldose reductase. Proteins, 80, 2012
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4PVB
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![BU of 4pvb by Molmil](/molmil-images/mine/4pvb) | Crystal structure of Aminopeptidase N in complex with the phosphonic acid analogue of leucine (D-(S)-LeuP) | Descriptor: | Aminopeptidase N, PHOSPHATE ION, SULFATE ION, ... | Authors: | Nocek, B, Vassiliou, S, Berlicki, L, Mulligan, R, Mucha, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2014-03-16 | Release date: | 2014-06-25 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of Aminopeptidase N in complex with the phosphonic acid analogue of leucine (D-(S)-LeuP) To be Published
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4PQA
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![BU of 4pqa by Molmil](/molmil-images/mine/4pqa) | Crystal Structure of succinyl-diaminopimelate desuccinylase from Neisseria meningitidis MC58 in complex with the Inhibitor Captopril | Descriptor: | L-CAPTOPRIL, SULFATE ION, Succinyl-diaminopimelate desuccinylase, ... | Authors: | Nocek, B, Starus, A, Holz, R, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2014-03-01 | Release date: | 2014-04-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Inhibition of the dapE-Encoded N-Succinyl-L,L-diaminopimelic Acid Desuccinylase from Neisseria meningitidis by L-Captopril. Biochemistry, 54, 2015
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4Q63
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![BU of 4q63 by Molmil](/molmil-images/mine/4q63) | Crystal Structure of Legionella Uncharacterized Protein Lpg0364 | Descriptor: | 1,2-ETHANEDIOL, CADMIUM ION, CHLORIDE ION, ... | Authors: | Kim, Y, Evdokimova, E, Savchenko, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2014-04-21 | Release date: | 2014-05-07 | Method: | X-RAY DIFFRACTION (1.953 Å) | Cite: | Crystal Structure of Legionella Uncharacterized Protein Lpg0364 To be Published
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2QXW
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![BU of 2qxw by Molmil](/molmil-images/mine/2qxw) | Perdeuterated alr2 in complex with idd594 | Descriptor: | Aldose reductase, CITRIC ACID, IDD594, ... | Authors: | Blakeley, M.P, Ruiz, F, Cachau, R, Hazemann, I, Meilleur, F, Mitschler, A, Ginell, S, Afonine, P, Ventura, O, Cousido-Siah, A, Joachimiak, A, Myles, D, Podjarny, A. | Deposit date: | 2007-08-13 | Release date: | 2008-01-22 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (0.8 Å) | Cite: | Quantum model of catalysis based on a mobile proton revealed by subatomic x-ray and neutron diffraction studies of h-aldose reductase. Proc.Natl.Acad.Sci.Usa, 105, 2008
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4ONW
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![BU of 4onw by Molmil](/molmil-images/mine/4onw) | Crystal structure of the catalytic domain of DapE protein from V.cholerea | Descriptor: | 1,2-ETHANEDIOL, 1,4-BUTANEDIOL, ACETATE ION, ... | Authors: | Nocek, B, Makowska-Grzyska, M, Jedrzejczak, R, Gu, M, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2014-01-29 | Release date: | 2014-04-23 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | The Dimerization Domain in DapE Enzymes Is required for Catalysis. Plos One, 9, 2014
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4OP4
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![BU of 4op4 by Molmil](/molmil-images/mine/4op4) | Crystal structure of the catalytic domain of DapE protein from V.cholerea in the Zn bound form | Descriptor: | 1,2-ETHANEDIOL, 1,4-BUTANEDIOL, GLYCEROL, ... | Authors: | Nocek, B, Makowska-Grzyska, M, Jedrzejczak, R, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | Deposit date: | 2014-02-04 | Release date: | 2014-04-23 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.651 Å) | Cite: | The Dimerization Domain in DapE Enzymes Is required for Catalysis. Plos One, 9, 2014
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3QOD
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![BU of 3qod by Molmil](/molmil-images/mine/3qod) | Crystal Structure of Heterocyst Differentiation Protein, HetR from Fischerella mv11 | Descriptor: | Heterocyst differentiation protein | Authors: | Kim, Y, Joachimiak, G, Gornicki, P, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2011-02-09 | Release date: | 2011-04-20 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3.38 Å) | Cite: | Structure of transcription factor HetR required for heterocyst differentiation in cyanobacteria. Proc.Natl.Acad.Sci.USA, 108, 2011
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4QHP
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![BU of 4qhp by Molmil](/molmil-images/mine/4qhp) | Crystal structure of Aminopeptidase N in complex with the phosphinic dipeptide analogue LL-(R,S)-hPheP[CH2]Phe(4-CH2NH2) | Descriptor: | (2R)-2-[4-(aminomethyl)benzyl]-3-[(R)-[(1R)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]propanoic acid, (2S)-2-[4-(aminomethyl)benzyl]-3-[(R)-[(1R)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]propanoic acid, Aminopeptidase N, ... | Authors: | Nocek, B, Joachimiak, A. | Deposit date: | 2014-05-28 | Release date: | 2014-09-24 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure-guided, single-point modifications in the phosphinic dipeptide structure yield highly potent and selective inhibitors of neutral aminopeptidases. J.Med.Chem., 57, 2014
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2P06
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![BU of 2p06 by Molmil](/molmil-images/mine/2p06) | Crystal structure of a predicted coding region AF_0060 from Archaeoglobus fulgidus DSM 4304 | Descriptor: | GLYCEROL, Hypothetical protein AF_0060, MAGNESIUM ION | Authors: | Nocek, B, Xu, X, Koniyenko, Y, Yakounine, A, Savchenko, A, Edwards, A, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2007-02-28 | Release date: | 2007-03-27 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of a predicted coding region AF_0060 from Archaeoglobus fulgidus DSM 4304 To be Published
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2BE3
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![BU of 2be3 by Molmil](/molmil-images/mine/2be3) | |
4RI0
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![BU of 4ri0 by Molmil](/molmil-images/mine/4ri0) | Serine Protease HtrA3, mutationally inactivated | Descriptor: | PHOSPHATE ION, Serine protease HTRA3 | Authors: | Osipiuk, J, Glaza, P, Wenta, T, Lipinska, B, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2014-10-03 | Release date: | 2014-10-29 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.272 Å) | Cite: | Structural and Functional Analysis of Human HtrA3 Protease and Its Subdomains. Plos One, 10, 2015
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3QOE
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![BU of 3qoe by Molmil](/molmil-images/mine/3qoe) | Crystal Structure of Heterocyst Differentiation Protein, HetR from Fischerella mv11 | Descriptor: | Heterocyst differentiation protein | Authors: | Kim, Y, Joachimiak, G, Gornicki, P, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2011-02-09 | Release date: | 2011-04-20 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.004 Å) | Cite: | Structure of transcription factor HetR required for heterocyst differentiation in cyanobacteria. Proc.Natl.Acad.Sci.USA, 108, 2011
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2ARK
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![BU of 2ark by Molmil](/molmil-images/mine/2ark) | Structure of a flavodoxin from Aquifex aeolicus | Descriptor: | Flavodoxin, GLYCEROL, PHOSPHATE ION | Authors: | Cuff, M.E, Quartey, P, Zhou, M, Cymborowski, M, Minor, W, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2005-08-19 | Release date: | 2005-10-25 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of a flavodoxin from Aquifex aeolicus To be Published
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2AZ4
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![BU of 2az4 by Molmil](/molmil-images/mine/2az4) | Crystal Structure of a Protein of Unknown Function from Enterococcus faecalis V583 | Descriptor: | ZINC ION, hypothetical protein EF2904 | Authors: | Zhang, R, Maltseva, N, Moy, S, Collart, F, Cymborowski, M, Minor, W, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2005-09-09 | Release date: | 2005-10-25 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The 2.0 A crystal structure of a hypothetical protein from Enterococcus faecalis V583 To be Published
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2AMF
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![BU of 2amf by Molmil](/molmil-images/mine/2amf) | Crystal structure of 1-Pyrroline-5-Carboxylate Reductase from Human Pathogen Streptococcus Pyogenes | Descriptor: | 1-Pyrroline-5-Carboxylate reductase, PROLINE, SODIUM ION | Authors: | Nocek, B, Lezondra, L, Holzle, D, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2005-08-09 | Release date: | 2005-09-27 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structures of Delta(1)-Pyrroline-5-carboxylate Reductase from Human Pathogens Neisseria meningitides and Streptococcus pyogenes J.Mol.Biol., 354, 2005
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