7MXG
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![BU of 7mxg by Molmil](/molmil-images/mine/7mxg) | PRMT5(M420T mutant):MEP50 complexed with inhibitor PF-06855800 | Descriptor: | 7-[(5R)-5-C-(4-chloro-3-fluorophenyl)-beta-D-ribofuranosyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine, Methylosome protein 50, Protein arginine N-methyltransferase 5 | Authors: | McTigue, M, Deng, Y.L, Liu, W, Brooun, A. | Deposit date: | 2021-05-19 | Release date: | 2021-11-17 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.395 Å) | Cite: | SAM-Competitive PRMT5 Inhibitor PF-06939999 Demonstrates Antitumor Activity in Splicing Dysregulated NSCLC with Decreased Liability of Drug Resistance. Mol.Cancer Ther., 21, 2022
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6KTC
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![BU of 6ktc by Molmil](/molmil-images/mine/6ktc) | Crystal structure of YBX1 CSD with m5C RNA | Descriptor: | Nuclease-sensitive element-binding protein 1, RNA (5'-R(P*GP*(5MC)P*CP*U)-3') | Authors: | Zou, F, Li, S. | Deposit date: | 2019-08-27 | Release date: | 2020-02-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.008 Å) | Cite: | DrosophilaYBX1 homolog YPS promotes ovarian germ line stem cell development by preferentially recognizing 5-methylcytosine RNAs. Proc.Natl.Acad.Sci.USA, 117, 2020
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6KUG
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![BU of 6kug by Molmil](/molmil-images/mine/6kug) | Crystal structure of YBX1 CSD with RNA | Descriptor: | Nuclease-sensitive element-binding protein 1, RNA (5'-R(P*GP*CP*CP*U)-3') | Authors: | Zou, F, Li, S. | Deposit date: | 2019-09-02 | Release date: | 2020-02-05 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | DrosophilaYBX1 homolog YPS promotes ovarian germ line stem cell development by preferentially recognizing 5-methylcytosine RNAs. Proc.Natl.Acad.Sci.USA, 117, 2020
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3V6S
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![BU of 3v6s by Molmil](/molmil-images/mine/3v6s) | |
4O91
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![BU of 4o91 by Molmil](/molmil-images/mine/4o91) | Crystal Structure of type II inhibitor NG25 bound to TAK1-TAB1 | Descriptor: | Mitogen-activated protein kinase kinase kinase 7/TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 chimera, N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-4-methyl-3-(1H-pyrrolo[2,3-b]pyridin-4-yloxy)benzamide | Authors: | Gurbani, D, Hunter, J.C, Tan, L, Westover, K.D. | Deposit date: | 2013-12-31 | Release date: | 2014-07-30 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.393 Å) | Cite: | Discovery of Type II Inhibitors of TGF beta-Activated Kinase 1 (TAK1) and Mitogen-Activated Protein Kinase Kinase Kinase Kinase 2 (MAP4K2). J.Med.Chem., 58, 2015
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3V6R
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![BU of 3v6r by Molmil](/molmil-images/mine/3v6r) | |
4ZQA
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![BU of 4zqa by Molmil](/molmil-images/mine/4zqa) | |
6XPD
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![BU of 6xpd by Molmil](/molmil-images/mine/6xpd) | |
6XPF
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![BU of 6xpf by Molmil](/molmil-images/mine/6xpf) | Cryo-EM structure of human ZnT8 WT, in the absence of zinc, determined in heterogeneous conformations- one subunit in an inward-facing and the other in an outward-facing conformation | Descriptor: | ZINC ION, Zinc transporter 8 | Authors: | Bai, X.C, Xue, J, Jiang, Y.X. | Deposit date: | 2020-07-08 | Release date: | 2020-08-05 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (5.9 Å) | Cite: | Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations. Elife, 9, 2020
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6XPE
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![BU of 6xpe by Molmil](/molmil-images/mine/6xpe) | Cryo-EM structure of human ZnT8 WT, in the presence of zinc, determined in outward-facing conformation | Descriptor: | ZINC ION, Zinc transporter 8 | Authors: | Bai, X.C, Xue, J, Jiang, Y.X. | Deposit date: | 2020-07-08 | Release date: | 2020-08-05 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations. Elife, 9, 2020
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3J8H
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![BU of 3j8h by Molmil](/molmil-images/mine/3j8h) | Structure of the rabbit ryanodine receptor RyR1 in complex with FKBP12 at 3.8 Angstrom resolution | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP1A, Ryanodine receptor 1, ZINC ION | Authors: | Yan, Z, Bai, X, Yan, C, Wu, J, Scheres, S.H.W, Shi, Y, Yan, N. | Deposit date: | 2014-10-26 | Release date: | 2014-12-10 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution. Nature, 517, 2015
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4LDJ
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![BU of 4ldj by Molmil](/molmil-images/mine/4ldj) | Crystal Structure of a GDP-bound G12C Oncogenic Mutant of Human GTPase KRas | Descriptor: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION | Authors: | Hunter, J.C, Gurbani, D, Chen, Z, Westover, K.D. | Deposit date: | 2013-06-24 | Release date: | 2014-06-04 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C. Proc.Natl.Acad.Sci.USA, 111, 2014
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4NMM
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![BU of 4nmm by Molmil](/molmil-images/mine/4nmm) | Crystal Structure of a G12C Oncogenic Variant of Human KRas Bound to a Novel GDP Competitive Covalent Inhibitor | Descriptor: | 5'-O-[(S)-{[(S)-[2-(acetylamino)ethoxy](hydroxy)phosphoryl]oxy}(hydroxy)phosphoryl]guanosine, GTPase KRas, MAGNESIUM ION | Authors: | Hunter, J.C, Gurbani, D, Lim, S.M, Westover, K.D. | Deposit date: | 2013-11-15 | Release date: | 2014-06-04 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C. Proc.Natl.Acad.Sci.USA, 111, 2014
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7YE6
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![BU of 7ye6 by Molmil](/molmil-images/mine/7ye6) | BAM-EspP complex structure with BamA-N427C/EspP-R1297C mutations in nanodisc | Descriptor: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ... | Authors: | Shen, C, Chang, S, Luo, Q, Zhang, Z, Luo, B, Lu, G, Zhu, X, Wei, X, Dong, C, Zhang, X, Tang, X, Dong, H. | Deposit date: | 2022-07-05 | Release date: | 2023-07-12 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis of BAM-mediated outer membrane beta-barrel protein assembly. Nature, 617, 2023
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7YE4
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![BU of 7ye4 by Molmil](/molmil-images/mine/7ye4) | BAM-EspP complex structure with BamA-G431C and G781C/EspP-N1293C and A1043C mutations in nanodisc | Descriptor: | Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ... | Authors: | Shen, C, Chang, S, Luo, Q, Zhang, Z, Luo, B, Lu, G, Zhu, X, Wei, X, Dong, C, Zhang, X, Tang, X, Dong, H. | Deposit date: | 2022-07-05 | Release date: | 2023-07-12 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis of BAM-mediated outer membrane beta-barrel protein assembly. Nature, 617, 2023
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7YQE
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![BU of 7yqe by Molmil](/molmil-images/mine/7yqe) | |
2N2H
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![BU of 2n2h by Molmil](/molmil-images/mine/2n2h) | Solution structure of Sds3 in complex with Sin3A | Descriptor: | Paired amphipathic helix protein Sin3a, Sin3 histone deacetylase corepressor complex component SDS3 | Authors: | Clark, M, Radhakrishnan, I. | Deposit date: | 2015-05-08 | Release date: | 2015-07-15 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Structural insights into the assembly of the histone deacetylase-associated Sin3L/Rpd3L corepressor complex. Proc.Natl.Acad.Sci.USA, 112, 2015
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3SQJ
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![BU of 3sqj by Molmil](/molmil-images/mine/3sqj) | Recombinant human serum albumin from transgenic plant | Descriptor: | MYRISTIC ACID, Serum albumin | Authors: | He, Y, Yang, D. | Deposit date: | 2011-07-05 | Release date: | 2011-11-02 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Large-scale production of functional human serum albumin from transgenic rice seeds. Proc.Natl.Acad.Sci.USA, 108, 2011
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7F65
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![BU of 7f65 by Molmil](/molmil-images/mine/7f65) | Bacetrial Cocaine Esterase with mutations T172R/G173Q/V116K/S117A/A51L, bound to benzoic acid | Descriptor: | BENZOIC ACID, Cocaine esterase, SULFATE ION | Authors: | Ouyang, P.F, Zhang, Y, Tong, J. | Deposit date: | 2021-06-24 | Release date: | 2021-09-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.202 Å) | Cite: | Computational Design and Crystal Structure of a Highly Efficient Benzoylecgonine Hydrolase. Angew.Chem.Int.Ed.Engl., 60, 2021
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