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3V6S

Discovery of potent and selective covalent inhibitors of JNK

Summary for 3V6S
Entry DOI10.2210/pdb3v6s/pdb
Related3V6R
DescriptorMitogen-activated protein kinase 10, 3-{[4-(dimethylamino)butanoyl]amino}-N-(4-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}phenyl)benzamide (3 entities in total)
Functional Keywordskinase fold, apoptosis, map kinase, cys modification, jnk, phosphorylation, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm: P53779
Total number of polymer chains2
Total formula weight85110.50
Authors
Park, H.,Laughlin, J.D.,LoGrasso, P.V. (deposition date: 2011-12-20, release date: 2012-02-01, Last modification date: 2012-07-25)
Primary citationZhang, T.,Inesta-Vaquera, F.,Niepel, M.,Zhang, J.,Ficarro, S.B.,Machleidt, T.,Xie, T.,Marto, J.A.,Kim, N.,Sim, T.,Laughlin, J.D.,Park, H.,LoGrasso, P.V.,Patricelli, M.,Nomanbhoy, T.K.,Sorger, P.K.,Alessi, D.R.,Gray, N.S.
Discovery of potent and selective covalent inhibitors of JNK.
Chem.Biol., 19:140-154, 2012
Cited by
PubMed: 22284361
DOI: 10.1016/j.chembiol.2011.11.010
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.97 Å)
Structure validation

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