1IA8
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![BU of 1ia8 by Molmil](/molmil-images/mine/1ia8) | THE 1.7 A CRYSTAL STRUCTURE OF HUMAN CELL CYCLE CHECKPOINT KINASE CHK1 | Descriptor: | CHK1 CHECKPOINT KINASE, SULFATE ION | Authors: | Chen, P, Luo, C, Deng, Y, Ryan, K, Register, J, Margosiak, S, Tempczyk-Russell, A, Nguyen, B, Myers, P, Lundgren, K, Chen Kan, C.-C, O'Connor, P.M. | Deposit date: | 2001-03-22 | Release date: | 2001-04-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | The 1.7 A crystal structure of human cell cycle checkpoint kinase Chk1: implications for Chk1 regulation. Cell(Cambridge,Mass.), 100, 2000
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8IAZ
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![BU of 8iaz by Molmil](/molmil-images/mine/8iaz) | Cryo-EM structure of the ISFba1 TnpB-reRNA-dsDNA complex | Descriptor: | DNA (5'-D(P*AP*CP*AP*TP*GP*GP*AP*CP*CP*AP*TP*CP*AP*GP*CP*TP*CP*CP*TP*AP*AP*TP*GP*G)-3'), DNA (5'-D(P*CP*CP*AP*TP*TP*AP*GP*GP*AP*GP*CP*TP*GP*AP*TP*G)-3'), RNA (207-MER), ... | Authors: | Yin, M, Zhou, F, Zhu, Y, Huang, Z. | Deposit date: | 2023-02-09 | Release date: | 2024-04-17 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Discovery and structural mechanism of DNA endonucleases guided by RAGATH-18-derived RNAs. Cell Res., 34, 2024
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5FLK
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![BU of 5flk by Molmil](/molmil-images/mine/5flk) | |
2LEY
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![BU of 2ley by Molmil](/molmil-images/mine/2ley) | Solution structure of (R7G)-Crp4 | Descriptor: | Alpha-defensin 4 | Authors: | Rosengren, K, Andersson, H.S, Haugaard-Kedstrom, L.M, Bengtsson, E, Daly, N.L, Figueredo, S.M, Qu, X, Craik, D.J, Ouellette, A.J. | Deposit date: | 2011-06-26 | Release date: | 2012-05-16 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | The alpha-defensin salt-bridge induces backbone stability to facilitate folding and confer proteolytic resistance. Amino Acids, 43, 2012
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2MFS
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![BU of 2mfs by Molmil](/molmil-images/mine/2mfs) | |
2MXM
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![BU of 2mxm by Molmil](/molmil-images/mine/2mxm) | |
2K1V
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![BU of 2k1v by Molmil](/molmil-images/mine/2k1v) | R3/I5 relaxin chimera | Descriptor: | Insulin-like peptide INSL5, Relaxin-3 | Authors: | Rosengren, K, Haugaard-Jonsson, L.M. | Deposit date: | 2008-03-17 | Release date: | 2008-04-08 | Last modified: | 2019-12-25 | Method: | SOLUTION NMR | Cite: | Structure of the R3/I5 Chimeric Relaxin Peptide, a Selective GPCR135 and GPCR142 Agonist. J.Biol.Chem., 283, 2008
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2KNM
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![BU of 2knm by Molmil](/molmil-images/mine/2knm) | |
2KNN
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![BU of 2knn by Molmil](/molmil-images/mine/2knn) | |
2LR9
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![BU of 2lr9 by Molmil](/molmil-images/mine/2lr9) | |
2LEW
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![BU of 2lew by Molmil](/molmil-images/mine/2lew) | Structural Plasticity of Paneth cell alpha-Defensins: Characterization of Salt-Bridge Deficient Analogues of Mouse Cryptdin-4 | Descriptor: | Alpha-defensin 4 | Authors: | Rosengren, K, Andersson, H.S, Haugaard-Kedstrom, L.M, Bengtsson, E, Daly, N.L, Craik, D.J. | Deposit date: | 2011-06-24 | Release date: | 2012-05-16 | Last modified: | 2013-06-19 | Method: | SOLUTION NMR | Cite: | The alpha-defensin salt-bridge induces backbone stability to facilitate folding and confer proteolytic resistance. Amino Acids, 43, 2012
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8D8R
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![BU of 8d8r by Molmil](/molmil-images/mine/8d8r) | SARS-CoV-2 Spike RBD in complex with DMAb 2196 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2196 heavy chain, 2196 light chain, ... | Authors: | Du, J, Cui, J, Pallesen, J. | Deposit date: | 2022-06-08 | Release date: | 2022-10-19 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2. Nat Commun, 13, 2022
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8D8Q
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![BU of 8d8q by Molmil](/molmil-images/mine/8d8q) | SARS-CoV-2 Spike RBD in complex with DMAbs 2130 and 2196 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2130 heavy chain, 2130 light chain, ... | Authors: | Du, J, Cui, J, Pallesen, J. | Deposit date: | 2022-06-08 | Release date: | 2022-10-19 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | DNA-delivered antibody cocktail exhibits improved pharmacokinetics and confers prophylactic protection against SARS-CoV-2. Nat Commun, 13, 2022
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5WTI
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![BU of 5wti by Molmil](/molmil-images/mine/5wti) | Crystal structure of the CRISPR-associated protein in complex with crRNA and DNA | Descriptor: | CRISPR-associated protein, DNA (28-MER), DNA (5'-D(P*GP*TP*GP*TP*GP*GP*AP*TP*TP*CP*CP*G)-3'), ... | Authors: | Wu, D, Guan, X, Zhu, Y, Huang, Z. | Deposit date: | 2016-12-13 | Release date: | 2017-11-01 | Method: | X-RAY DIFFRACTION (2.682 Å) | Cite: | Structural basis of stringent PAM recognition by CRISPR-C2c1 in complex with sgRNA Cell Res., 27, 2017
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4UXZ
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![BU of 4uxz by Molmil](/molmil-images/mine/4uxz) | Structure of delta7-DgkA-syn in 7.9 MAG to 2.18 angstrom resolution | Descriptor: | (2R)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate, (2S)-2,3-dihydroxypropyl (7Z)-hexadec-7-enoate, ACETATE ION, ... | Authors: | Li, D, Howe, N, Caffrey, M. | Deposit date: | 2014-08-27 | Release date: | 2015-09-30 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Ternary Structure Reveals Mechanism of a Membrane Diacylglycerol Kinase. Nat.Commun., 6, 2015
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7EDO
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![BU of 7edo by Molmil](/molmil-images/mine/7edo) | First insight into marsupial MHC I peptide presentation: immune features of lower mammals paralleled with bats | Descriptor: | Beta-2-microglobulin, CYS-ASN-VAL-THR-LEU-ASN-TYR-PRO, MHC class I antigen | Authors: | Wang, P.Y, Yue, C, Lu, D, Liu, K.F, Liu, S, Yao, S.J, Chai, Y, Qi, J.X, Lou, Y.L, Sun, Z.Y, Gao, G.F, Liu, W.J. | Deposit date: | 2021-03-16 | Release date: | 2021-08-11 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Peptide Presentations of Marsupial MHC Class I Visualize Immune Features of Lower Mammals Paralleled with Bats. J Immunol., 207, 2021
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8R74
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![BU of 8r74 by Molmil](/molmil-images/mine/8r74) | Galectin-1 in complex with thiogalactoside derivative | Descriptor: | (2~{R},3~{R},4~{S},5~{R},6~{R})-2-(3,4-dichlorophenyl)sulfanyl-6-(hydroxymethyl)-4-[4-(2-oxidanyl-1,3-thiazol-4-yl)-1,2,3-triazol-1-yl]oxane-3,5-diol, Galectin-1 | Authors: | Hakansson, M, Diehl, C, Peterson, K, Zetterberg, F, Nilsson, U. | Deposit date: | 2023-11-23 | Release date: | 2024-06-05 | Last modified: | 2024-06-19 | Method: | X-RAY DIFFRACTION (1.54 Å) | Cite: | Discovery of the Selective and Orally Available Galectin-1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer. J.Med.Chem., 67, 2024
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7QA1
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![BU of 7qa1 by Molmil](/molmil-images/mine/7qa1) | The structure of natural crystals of the Lysinibacillus sphaericus Tpp49Aa1 pesticidal protein elucidated using serial femtosecond crystallography at an X-ray free electron laser | Descriptor: | Toxin-10 pesticidal protein (Tpp) 49Aa1 | Authors: | Williamson, L.J, Rizkallah, P.J, Berry, C, Oberthur, D, Galchenkova, M, Yefanov, O, Bean, R, Best, H.L. | Deposit date: | 2021-11-15 | Release date: | 2023-05-17 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of the Lysinibacillus sphaericus Tpp49Aa1 pesticidal protein elucidated from natural crystals using MHz-SFX. Proc.Natl.Acad.Sci.USA, 120, 2023
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4MBJ
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7DHT
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![BU of 7dht by Molmil](/molmil-images/mine/7dht) | |
6IUF
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![BU of 6iuf by Molmil](/molmil-images/mine/6iuf) | Crystal structure of Anti-CRISPR protein AcrVA5 | Descriptor: | ACETYL COENZYME *A, GLYCEROL, protein-a | Authors: | Dong, L, Guan, X, Zhu, Y, Huang, Z. | Deposit date: | 2018-11-28 | Release date: | 2019-04-10 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.052 Å) | Cite: | An anti-CRISPR protein disables type V Cas12a by acetylation. Nat. Struct. Mol. Biol., 26, 2019
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6IV6
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![BU of 6iv6 by Molmil](/molmil-images/mine/6iv6) | Cryo-EM structure of AcrVA5-acetylated MbCas12a in complex with crRNA | Descriptor: | RNA (59-MER), nuclease | Authors: | Dong, L, Li, N, Guan, X, Zhu, Y, Gao, N, Huang, Z. | Deposit date: | 2018-12-02 | Release date: | 2019-04-10 | Last modified: | 2019-11-06 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | An anti-CRISPR protein disables type V Cas12a by acetylation. Nat. Struct. Mol. Biol., 26, 2019
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5CW5
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![BU of 5cw5 by Molmil](/molmil-images/mine/5cw5) | Structure of CfBRCC36-CfKIAA0157 complex (QSQ mutant) | Descriptor: | BRCA1/BRCA2-containing complex subunit 3, Protein FAM175B | Authors: | Zeqiraj, E. | Deposit date: | 2015-07-27 | Release date: | 2015-09-16 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.736 Å) | Cite: | Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function. Mol.Cell, 59, 2015
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5CW3
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![BU of 5cw3 by Molmil](/molmil-images/mine/5cw3) | Structure of CfBRCC36-CfKIAA0157 complex (Zn Edge) | Descriptor: | BRCA1/BRCA2-containing complex subunit 3, Protein FAM175B, ZINC ION | Authors: | Zeqiraj, E. | Deposit date: | 2015-07-27 | Release date: | 2015-09-16 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function. Mol.Cell, 59, 2015
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8INP
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![BU of 8inp by Molmil](/molmil-images/mine/8inp) | A reversible glycosyltransferase of tectorigenin - Bc7OUGT | Descriptor: | Bc7OUGT, URIDINE-5'-DIPHOSPHATE, beta-D-glucopyranose | Authors: | Zhang, Z.Y, Lu, L, Guan, Z.F, Cheng, W.J. | Deposit date: | 2023-03-10 | Release date: | 2023-08-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | Functional characterization and structural basis of a reversible glycosyltransferase involves in plant chemical defence. Plant Biotechnol J, 21, 2023
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