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5IMX
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BU of 5imx by Molmil
Anaplastic lymphoma kinase (ALK) catalytic domain complexed with novel inhibitor 3-sulfonylpyrazol-4-amino pyrimidine
Descriptor: 5-chloro-N~2~-{5-methyl-4-(1-methylpiperidin-4-yl)-2-[(propan-2-yl)oxy]phenyl}-N~4~-{1-methyl-3-[(propan-2-yl)sulfonyl]-1H-pyrazol-4-yl}pyrimidine-2,4-diamine, ALK tyrosine kinase receptor
Authors:Wang, C, Zhang, P, Dong, J.
Deposit date:2016-03-07
Release date:2016-05-04
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Design and synthesis of novel 3-sulfonylpyrazol-4-amino pyrimidines as potent anaplastic lymphoma kinase (ALK) inhibitors.
Bioorg.Med.Chem.Lett., 26, 2016
1L0Q
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BU of 1l0q by Molmil
Tandem YVTN beta-propeller and PKD domains from an archaeal surface layer protein
Descriptor: Surface layer protein
Authors:Jing, H, Takagi, J, Liu, J.-H, Lindgren, S, Zhang, R.-G, Joachimiak, A, Wang, J.-H, Springer, T.A.
Deposit date:2002-02-12
Release date:2002-11-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Archaeal Surface Layer Proteins Contain beta Propeller, PKD, and beta Helix Domains and Are Related to Metazoan Cell Surface Proteins.
Structure, 10, 2002
5F6I
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BU of 5f6i by Molmil
Crystal Structure of Tier 2 Neutralizing Antibody DH428 from a Rhesus Macaque
Descriptor: DH428 Antibody Heavy Chain, DH428 Antibody Light Chain
Authors:Fera, D, Harrison, S.C.
Deposit date:2015-12-06
Release date:2016-01-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site.
Cell Rep, 14, 2016
6EB0
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BU of 6eb0 by Molmil
STRUCTURE OF 4-HYDROXYPHENYLACETATE 3-MONOOXYGENASE (HPAB), OXYGENASE COMPONENT FROM ESCHERICHIA COLI
Descriptor: 4-hydroxyphenylacetate 3-monooxygenase, oxygenase subunit, ACETATE ION
Authors:Zhou, D, Kandavelu, P, Zhang, H, Wang, B.C, Yan, Y, Rose, J.
Deposit date:2018-08-03
Release date:2019-05-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Structural Insights into Catalytic Versatility of the Flavin-dependent Hydroxylase (HpaB) from Escherichia coli.
Sci Rep, 9, 2019
2O8M
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BU of 2o8m by Molmil
Crystal structure of the S139A mutant of Hepatitis C Virus NS3/4A protease
Descriptor: Protease, SODIUM ION, ZINC ION
Authors:Fischmann, T.O, Prongay, A.J, Madison, V.M, Yao, N.
Deposit date:2006-12-12
Release date:2007-10-09
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery of the HCV NS3/4A protease inhibitor (1R,5S)-N-[3-amino-1-(cyclobutylmethyl)-2,3-dioxopropyl]-3- [2(S)-[[[(1,1-dimethylethyl)amino]carbonyl]amino]-3,3-dimethyl-1-oxobutyl]- 6,6-dimethyl-3-azabicyclo[3.1.0]hexan-2(S)-carboxamide (Sch 503034) II. Key steps in structure-based optimization
J.Med.Chem., 50, 2007
5Z9J
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BU of 5z9j by Molmil
Identification of the functions of unusual cytochrome p450-like monooxygenases involved in microbial secondary metablism
Descriptor: PROTOPORPHYRIN IX CONTAINING FE, Putative P450-like enzyme, TRIS(HYDROXYETHYL)AMINOMETHANE
Authors:Lu, M, Lin, L, Zhang, C, Chen, Y.
Deposit date:2018-02-03
Release date:2019-02-06
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Riboflavin Is Directly Involved in the N-Dealkylation Catalyzed by Bacterial Cytochrome P450 Monooxygenases.
Chembiochem, 2020
1YY6
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BU of 1yy6 by Molmil
The Crystal Structure of the N-terminal domain of HAUSP/USP7 complexed with an EBNA1 peptide
Descriptor: Epstein-Barr nuclear antigen-1, SODIUM ION, Ubiquitin carboxyl-terminal hydrolase 7
Authors:Saridakis, V, Sheng, Y, Sarkari, F, Holowaty, M, Shire, K, Nguyen, T, Zhang, R, Liao, J, Lee, W, Edwards, A.M, Arrowsmith, C.H, Frappier, L.
Deposit date:2005-02-23
Release date:2005-04-05
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization.
Mol.Cell, 18, 2005
5Z9I
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BU of 5z9i by Molmil
Identification of the functions of unusual cytochrome p450-like monooxygenases involved in microbial secondary metablism
Descriptor: PROTOPORPHYRIN IX CONTAINING FE, Putative P450-like enzyme
Authors:Lu, M, Lin, L, Zhang, C, Chen, Y.
Deposit date:2018-02-03
Release date:2019-02-06
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.199 Å)
Cite:Riboflavin Is Directly Involved in the N-Dealkylation Catalyzed by Bacterial Cytochrome P450 Monooxygenases.
Chembiochem, 2020
5GI4
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BU of 5gi4 by Molmil
DEAD-box RNA helicase
Descriptor: ATP-dependent RNA helicase DeaD
Authors:Xu, L, Wang, L, Li, F, Wu, L, Shi, Y.
Deposit date:2016-06-22
Release date:2017-05-31
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.244 Å)
Cite:Insights into the Structure of Dimeric RNA Helicase CsdA and Indispensable Role of Its C-Terminal Regions.
Structure, 25, 2017
5GJU
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BU of 5gju by Molmil
DEAD-box RNA helicase
Descriptor: ADENOSINE MONOPHOSPHATE, ATP-dependent RNA helicase DeaD
Authors:Xu, L, Li, F, Wang, L, Shi, Y.
Deposit date:2016-07-02
Release date:2017-05-31
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Insights into the Structure of Dimeric RNA Helicase CsdA and Indispensable Role of Its C-Terminal Regions.
Structure, 25, 2017
2ZN7
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BU of 2zn7 by Molmil
CRYSTAL STRUCTURES OF PTP1B-Inhibitor Complexes
Descriptor: 4-bromo-3-(carboxymethoxy)-5-{3-[cyclohexyl(phenylcarbonyl)amino]phenyl}thiophene-2-carboxylic acid, Tyrosine-protein phosphatase non-receptor type 1
Authors:Xu, W, Wu, J.
Deposit date:2008-04-22
Release date:2008-10-07
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-based optimization of protein tyrosine phosphatase-1 B inhibitors: capturing interactions with arginine 24
Chemmedchem, 3, 2008
5F6H
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BU of 5f6h by Molmil
Crystal Structure of Tier 2 Neutralizing Antibody DH427 from a Rhesus Macaque
Descriptor: DH427 Antibody Heavy Chain, DH427 Antibody Light Chain
Authors:Fera, D, Harrison, S.C.
Deposit date:2015-12-06
Release date:2016-01-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site.
Cell Rep, 14, 2016
5F6J
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BU of 5f6j by Molmil
Crystal Structure of Tier 2 Neutralizing Antibody DH427 from a Rhesus Macaque in Complex with HIV-1 gp120 Core
Descriptor: DH427 Antibody Heavy Chain, DH427 Antibody Light Chain, ENVELOPE GLYCOPROTEIN GP120 of HIV-1 clade C
Authors:Fera, D, Harrison, S.C.
Deposit date:2015-12-06
Release date:2016-01-13
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (6.63 Å)
Cite:Structural Constraints of Vaccine-Induced Tier-2 Autologous HIV Neutralizing Antibodies Targeting the Receptor-Binding Site.
Cell Rep, 14, 2016
4QQY
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BU of 4qqy by Molmil
Crystal structure of T. fusca Cas3-ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, CRISPR-associated helicase, Cas3 family, ...
Authors:Ke, A, Huo, Y, Nam, K.H.
Deposit date:2014-06-30
Release date:2014-08-27
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation.
Nat.Struct.Mol.Biol., 21, 2014
4QQX
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BU of 4qqx by Molmil
Crystal structure of T. fusca Cas3-ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, CRISPR-associated helicase, Cas3 family, ...
Authors:Ke, A, Huo, Y, Nam, K.H.
Deposit date:2014-06-30
Release date:2014-08-20
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.34 Å)
Cite:Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation.
Nat.Struct.Mol.Biol., 21, 2014
4QQW
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BU of 4qqw by Molmil
Crystal structure of T. fusca Cas3
Descriptor: CRISPR-associated helicase, Cas3 family, DNA (5'-D(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*A)-3'), ...
Authors:Ke, A, Huo, Y, Nam, K.H.
Deposit date:2014-06-30
Release date:2014-08-27
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.664 Å)
Cite:Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation.
Nat.Struct.Mol.Biol., 21, 2014
2DVA
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BU of 2dva by Molmil
Crystal structure of peanut lectin GAL-BETA-1,3-GALNAC-ALPHA-O-ME (Methyl-T-antigen) complex
Descriptor: CALCIUM ION, Galactose-binding lectin, MANGANESE (II) ION, ...
Authors:Natchiar, S.K, Srinivas, O, Mitra, N, Surolia, A, Jayaraman, N, Vijayan, M.
Deposit date:2006-07-30
Release date:2006-11-07
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural studies on peanut lectin complexed with disaccharides involving different linkages: further insights into the structure and interactions of the lectin
ACTA CRYSTALLOGR.,SECT.D, 62, 2006
2DVG
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BU of 2dvg by Molmil
Crystal structure of peanut lectin GAL-ALPHA-1,6-GLC complex
Descriptor: CALCIUM ION, Galactose-binding lectin, MANGANESE (II) ION, ...
Authors:Natchiar, S.K, Srinivas, O, Mitra, N, Surolia, A, Jayaraman, N, Vijayan, M.
Deposit date:2006-07-31
Release date:2006-11-07
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.78 Å)
Cite:Structural studies on peanut lectin complexed with disaccharides involving different linkages: further insights into the structure and interactions of the lectin
ACTA CRYSTALLOGR.,SECT.D, 62, 2006
2DVD
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BU of 2dvd by Molmil
Crystal structure of peanut lectin GAL-ALPHA-1,3-GAL complex
Descriptor: CALCIUM ION, Galactose-binding lectin, MANGANESE (II) ION, ...
Authors:Natchiar, S.K, Srinivas, O, Mitra, N, Surolia, A, Jayaraman, N, Vijayan, M.
Deposit date:2006-07-31
Release date:2006-11-07
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural studies on peanut lectin complexed with disaccharides involving different linkages: further insights into the structure and interactions of the lectin
ACTA CRYSTALLOGR.,SECT.D, 62, 2006
2DV9
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BU of 2dv9 by Molmil
Crystal structure of peanut lectin GAL-BETA-1,3-GAL complex
Descriptor: CALCIUM ION, Galactose-binding lectin, MANGANESE (II) ION, ...
Authors:Natchiar, S.K, Srinivas, O, Mitra, N, Surolia, A, Jayaraman, N, Vijayan, M.
Deposit date:2006-07-30
Release date:2006-11-07
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Structural studies on peanut lectin complexed with disaccharides involving different linkages: further insights into the structure and interactions of the lectin
ACTA CRYSTALLOGR.,SECT.D, 62, 2006
5U0U
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BU of 5u0u by Molmil
Crystal Structure of DH270.1 (unliganded, single-chain Fv) from the DH270 Broadly Neutralizing N332-glycan Dependent Lineage
Descriptor: DH270.1 single-chain variable fragment
Authors:Fera, D, Harrison, S.C.
Deposit date:2016-11-27
Release date:2017-03-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.428 Å)
Cite:Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.
Sci Transl Med, 9, 2017
5U0R
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BU of 5u0r by Molmil
Crystal Structure of DH270.UCA1 (unliganded) from the DH270 Broadly Neutralizing N332-glycan Dependent Lineage
Descriptor: DH270.UCA1 heavy chain, DH270.UCA1 light chain, SULFATE ION
Authors:Fera, D, Harrison, S.C.
Deposit date:2016-11-26
Release date:2017-03-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.295 Å)
Cite:Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.
Sci Transl Med, 9, 2017
5INW
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BU of 5inw by Molmil
Structure of reaction loop cleaved lamprey angiotensinogen
Descriptor: C-terminal peptide of Putative angiotensinogen, Putative angiotensinogen, SULFATE ION
Authors:Wei, H, Zhou, A.
Deposit date:2016-03-08
Release date:2016-10-05
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Heparin Binds Lamprey Angiotensinogen and Promotes Thrombin Inhibition through a Template Mechanism
J.Biol.Chem., 291, 2016
5TPL
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BU of 5tpl by Molmil
Crystal Structure of DH270.3 (unliganded) from the DH270 Broadly Neutralizing N332-glycan Dependent Lineage
Descriptor: DH270.3 Fab heavy chain, DH270.3 Fab light chain
Authors:Fera, D, Harrison, S.C.
Deposit date:2016-10-20
Release date:2017-03-15
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Staged induction of HIV-1 glycan-dependent broadly neutralizing antibodies.
Sci Transl Med, 9, 2017
6A68
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BU of 6a68 by Molmil
the crystal structure of rat calcium-dependent activator protein for secretion (CAPS) DAMH domain
Descriptor: Calcium-dependent secretion activator 1, POTASSIUM ION
Authors:Zhou, H, Wei, Z.Q, Yao, D.Q, Zhang, R.G, Ma, C.
Deposit date:2018-06-26
Release date:2019-03-13
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.901 Å)
Cite:Structural and Functional Analysis of the CAPS SNARE-Binding Domain Required for SNARE Complex Formation and Exocytosis.
Cell Rep, 26, 2019

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数据于2024-07-03公开中

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