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Ternary signalling complex of BMP10 bound to ALK1 and BMPRII
Descriptor:	Bone morphogenetic protein 10, Bone morphogenetic protein receptor type-2, Serine/threonine-protein kinase receptor R3
Authors:	Guo, J, Yu, M, Read, R.J, Li, W.
Deposit date:	2021-09-13
Release date:	2022-05-11
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (3.6 Å)
Cite:	Crystal structures of BMPRII extracellular domain in binary and ternary receptor complexes with BMP10. Nat Commun, 13, 2022

5LU8

CRYSTAL STRUCTURE OF YVAD-CMK BOUND HUMAN LEGUMAIN (AEP) IN COMPLEX WITH COMPOUND 11B
Descriptor:	2,4-di(morpholin-4-yl)aniline, 2-acetamido-2-deoxy-beta-D-glucopyranose, AC-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE, ...
Authors:	Dall, E, Ye, K, Brandstetter, H.
Deposit date:	2016-09-08
Release date:	2017-03-29
Last modified:	2024-11-13
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nat Commun, 8, 2017

8R7R

human connexin36 gap junction channel in complex with quinidine
Descriptor:	Gap junction delta-2 protein, Quinidine
Authors:	Ding, X.Y, Blum, T.B, Korkhov, V.M.
Deposit date:	2023-11-27
Release date:	2024-10-30
Last modified:	2025-05-14
Method:	ELECTRON MICROSCOPY (2.97 Å)
Cite:	Structural basis of connexin-36 gap junction channel inhibition. Cell Discov, 10, 2024

5LU9

Crystal structure of YVAD-cmk bound human legumain (AEP) in complex with compound 11
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 7-(morpholin-4-yl)-2,1,3-benzoxadiazol-4-amine, AC-TYR-VAL-ALA-ASP-CHLOROMETHYLKETONE, ...
Authors:	Dall, E, Ye, K, Brandstetter, H.
Deposit date:	2016-09-08
Release date:	2017-03-29
Last modified:	2024-10-16
Method:	X-RAY DIFFRACTION (2.27 Å)
Cite:	Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nat Commun, 8, 2017

8R7Q

human connexin-36 gap junction channel in complex with quinine
Descriptor:	Gap junction delta-2 protein, Quinine
Authors:	Ding, X.Y, Blum, T.B, Korkhov, V.M.
Deposit date:	2023-11-27
Release date:	2024-07-03
Last modified:	2024-11-06
Method:	ELECTRON MICROSCOPY (2.78 Å)
Cite:	Structural basis of connexin-36 gap junction channel inhibition. Cell Discov, 10, 2024

8R7P

human connexin-36 gap junction channel
Descriptor:	Gap junction delta-2 protein
Authors:	Ding, X.Y, Blum, T.B, Korkhov, V.M.
Deposit date:	2023-11-27
Release date:	2024-07-03
Last modified:	2024-11-13
Method:	ELECTRON MICROSCOPY (2.53 Å)
Cite:	Structural basis of connexin-36 gap junction channel inhibition. Cell Discov, 10, 2024

8QOJ

human connexin-36 gap junction channel in complex with mefloquine
Descriptor:	(11R,12S)- Mefloquine, Gap junction delta-2 protein
Authors:	Ding, X.Y, Blum, T.B, Korkhov, V.M.
Deposit date:	2023-09-29
Release date:	2024-07-03
Last modified:	2024-11-13
Method:	ELECTRON MICROSCOPY (2.13 Å)
Cite:	Structural basis of connexin-36 gap junction channel inhibition. Cell Discov, 10, 2024

5LUB

Crystal structure of human legumain (AEP) in complex with compound 11
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-(morpholin-4-yl)-2,1,3-benzoxadiazol-4-amine, ...
Authors:	Dall, E, Ye, K, Brandstetter, H.
Deposit date:	2016-09-08
Release date:	2017-03-29
Last modified:	2024-11-06
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nat Commun, 8, 2017

5LUA

Crystal structure of human legumain (AEP) in complex with compound 11b
Descriptor:	2,4-di(morpholin-4-yl)aniline, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Dall, E, Ye, K, Brandstetter, H.
Deposit date:	2016-09-08
Release date:	2017-03-29
Last modified:	2024-11-13
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Inhibition of delta-secretase improves cognitive functions in mouse models of Alzheimer's disease. Nat Commun, 8, 2017

9LGM

Cryo-EM structure of GPR4 complexed with Gs in pH8.0
Descriptor:	G-protein coupled receptor 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:	Yue, X.L, Wu, L.J, Hua, T, Liu, Z.J.
Deposit date:	2025-01-10
Release date:	2025-04-23
Last modified:	2025-06-25
Method:	ELECTRON MICROSCOPY (2.84 Å)
Cite:	Structural basis of stepwise proton sensing-mediated GPCR activation. Cell Res., 35, 2025

8PO4

Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 33 bound to EGFR[V948R]
Descriptor:	1-cyclopropyl-~{N}-[3-[1-(1-propanoylazetidin-3-yl)-4-pyridin-4-yl-pyrazol-3-yl]phenyl]imidazole-4-carboxamide, ADENOSINE-5'-TRIPHOSPHATE, Epidermal growth factor receptor, ...
Authors:	Hargreaves, D.
Deposit date:	2023-07-03
Release date:	2024-06-05
Last modified:	2024-11-20
Method:	X-RAY DIFFRACTION (1.621 Å)
Cite:	Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. J.Med.Chem., 67, 2024

8PNZ

Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 16 bound to EGFR
Descriptor:	1-[(3~{S})-3-[4-(6,7-dimethoxyquinazolin-4-yl)-3-(3-methoxyphenyl)pyrazol-1-yl]pyrrolidin-1-yl]propan-1-one, Epidermal growth factor receptor
Authors:	Hargreaves, D.
Deposit date:	2023-07-03
Release date:	2024-06-05
Last modified:	2024-11-06
Method:	X-RAY DIFFRACTION (2.51 Å)
Cite:	Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. J.Med.Chem., 67, 2024

7BRO

Crystal structure of the 2019-nCoV main protease
Descriptor:	3C-like proteinase
Authors:	Fu, L.F.
Deposit date:	2020-03-29
Release date:	2020-05-13
Last modified:	2023-11-29
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Both Boceprevir and GC376 efficaciously inhibit SARS-CoV-2 by targeting its main protease. Nat Commun, 11, 2020

5K23

Crystal structure of the complex between human phosphatase PRL-2 in the oxidized state with the Bateman domain of human magnesium transporter CNNM3
Descriptor:	Metal transporter CNNM3, Protein tyrosine phosphatase type IVA 2
Authors:	Gulerez, I, Kozlov, G, Gehring, K.
Deposit date:	2016-05-18
Release date:	2016-10-12
Last modified:	2024-11-20
Method:	X-RAY DIFFRACTION (2.96 Å)
Cite:	PRL3 phosphatase active site is required for binding the putative magnesium transporter CNNM3. Sci Rep, 7, 2017

7BZV

Crystal structure of 2-aminomuconic 6-semialdehyde dehydrogenase from Pseudomonas species AP-3
Descriptor:	2-aminomuconic 6-semialdehyde dehydrogenase, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:	Shi, Q.L, Chen, Y.J, Su, D.
Deposit date:	2020-04-28
Release date:	2021-04-28
Last modified:	2024-06-19
Method:	X-RAY DIFFRACTION (1.988 Å)
Cite:	The tetrameric assembly of 2-aminomuconic 6-semialdehyde dehydrogenase is a functional requirement of cofactor NAD + binding. Environ.Microbiol., 2021

4RB2

Crystal structure of Magnetospirillum gryphiswaldense MSR-1 SeMet-Fur-Mn2+-feoAB1 operator
Descriptor:	DNA (25-MER), DNA-binding transcriptional dual regulator of siderophore biosynthesis and transport(Fur family), MANGANESE (II) ION
Authors:	Deng, Z, Chen, Z.
Deposit date:	2014-09-12
Release date:	2015-07-15
Last modified:	2024-11-20
Method:	X-RAY DIFFRACTION (2.82 Å)
Cite:	Mechanistic insights into metal ion activation and operator recognition by the ferric uptake regulator. Nat Commun, 6

6SLC

Mutations in SsgB correlate to longitudinal cell division during sporulation of Streptomyces coelicolor
Descriptor:	DI(HYDROXYETHYL)ETHER, GLYCEROL, PHOSPHATE ION, ...
Authors:	Xiao, X.S, Willemse, J.
Deposit date:	2019-08-19
Release date:	2020-08-26
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Ectopic positioning of the cell division plane is associated with single amino acid substitutions in the FtsZ-recruiting SsgB in Streptomyces . Open Biology, 11, 2021

4RB0

Crystal structure of Magnetospirillum gryphiswaldense MSR-1 SeMet-Apo-Fur
Descriptor:	CITRATE ANION, DNA-binding transcriptional dual regulator of siderophore biosynthesis and transport(Fur family), SULFATE ION
Authors:	Deng, Z, Chen, Z.
Deposit date:	2014-09-12
Release date:	2015-07-15
Last modified:	2024-11-20
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	Mechanistic insights into metal ion activation and operator recognition by the ferric uptake regulator. Nat Commun, 6

6RNW

The crystal structure of Thermosynechococcus elongatus protochlorophyllide oxidoreductase (POR) in complex with NADP.
Descriptor:	NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, NADPH-protochlorophyllide oxidoreductase
Authors:	Levy, C.W.
Deposit date:	2019-05-09
Release date:	2019-10-30
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (1.92 Å)
Cite:	Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis. Nature, 574, 2019

6RNV

The crystal structure of Thermosynechococcus elongatus protochlorophyllide oxidoreductase (POR)
Descriptor:	CHLORIDE ION, Thermosynechococcus elongatus protochlorophyllide oxidoreductase (POR)
Authors:	Levy, C.W.
Deposit date:	2019-05-09
Release date:	2019-10-30
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (1.27 Å)
Cite:	Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis. Nature, 574, 2019

6R46

Crystal structure of LPOR (Thermosynechococcus elongatus) complexed with NADP+ at 2.5A resolution
Descriptor:	CHLORIDE ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, NADPH-protochlorophyllide oxidoreductase, ...
Authors:	Zhou, A, Feng, L.
Deposit date:	2019-03-22
Release date:	2019-10-30
Last modified:	2024-05-15
Method:	X-RAY DIFFRACTION (2.5 Å)
Cite:	Structural basis for enzymatic photocatalysis in chlorophyll biosynthesis. Nature, 574, 2019

8PO2

Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 33 bound to EGFRinsNPG [V948R]
Descriptor:	1-cyclopropyl-~{N}-[3-[1-(1-propanoylazetidin-3-yl)-4-pyridin-4-yl-pyrazol-3-yl]phenyl]imidazole-4-carboxamide, Epidermal growth factor receptor
Authors:	Hargreaves, D.
Deposit date:	2023-07-03
Release date:	2024-06-05
Last modified:	2024-11-20
Method:	X-RAY DIFFRACTION (2.28 Å)
Cite:	Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. J.Med.Chem., 67, 2024

8PO0

Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 12 bound to EGFRinsNPG
Descriptor:	1-[3-[7-methoxy-4-[3-(3-methoxyphenyl)-1~{H}-pyrazol-4-yl]quinazolin-6-yl]oxyazetidin-1-yl]propan-1-one, Epidermal growth factor receptor
Authors:	Hargreaves, D.
Deposit date:	2023-07-03
Release date:	2024-06-05
Last modified:	2024-11-13
Method:	X-RAY DIFFRACTION (2.523 Å)
Cite:	Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. J.Med.Chem., 67, 2024

8PO3

Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 18 bound to EGFR[V948R]
Descriptor:	2-methyl-5-[[3-[1-[(3~{S})-1-propanoylpyrrolidin-3-yl]-4-pyridin-4-yl-pyrazol-3-yl]phenoxy]methyl]-3~{H}-isoindol-1-one, Epidermal growth factor receptor
Authors:	Hargreaves, D.
Deposit date:	2023-07-03
Release date:	2024-06-05
Last modified:	2024-11-06
Method:	X-RAY DIFFRACTION (2.13 Å)
Cite:	Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. J.Med.Chem., 67, 2024

4RAY

Crystal structure of Magnetospirillum gryphiswaldense MSR-1 Apo-Fur
Descriptor:	CITRATE ANION, DNA-binding transcriptional dual regulator of siderophore biosynthesis and transport(Fur family), SULFATE ION
Authors:	Deng, Z, Liu, Z, Chen, Z.
Deposit date:	2014-09-12
Release date:	2015-07-15
Last modified:	2024-02-28
Method:	X-RAY DIFFRACTION (1.55 Å)
Cite:	Mechanistic insights into metal ion activation and operator recognition by the ferric uptake regulator. Nat Commun, 6

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Total results:	2019
Displayed results:	25
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