5UMN
 
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5UXQ
 | | Structure of anti-HIV trimer apex antibody PGT143 | | Descriptor: | PGT143 Fab Heavy Chain, PGT143 Fab Light Chain | | Authors: | Kong, L, Wilson, I.A. | | Deposit date: | 2017-02-23 | | Release date: | 2017-04-19 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.415 Å) | | Cite: | A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic Beta-Hairpin Structure
Immunity, 46, 2017
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5UY3
 | | Crystal structure of human Fab PGT144, a broadly reactive and potent HIV-1 neutralizing antibody | | Descriptor: | Antibody PGT144 Fab heavy chain, Antibody PGT144 Fab light chain | | Authors: | Julien, J.-P, Lee, J.H, Wilson, I.A. | | Deposit date: | 2017-02-23 | | Release date: | 2017-04-19 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic beta-Hairpin Structure.
Immunity, 46, 2017
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8UHH
 | | anti-Phosphohistidine Fab hSC44.ck.elbow.20.N32F | | Descriptor: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ... | | Authors: | Kalagiri, R, Stanfield, R.L, Hunter, T, Wilson, I.A. | | Deposit date: | 2023-10-09 | | Release date: | 2025-03-19 | | Method: | X-RAY DIFFRACTION (1.84 Å) | | Cite: | Using phage display for rational engineering of a higher affinity humanized 3' phosphohistidine-specific antibody.
Biorxiv, 2024
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8UIH
 | | anti-Phosphohistidine Fab hSC44.ck.20 with 3pTza peptide | | Descriptor: | 1,2-ETHANEDIOL, 3ptza peptide, hSC44.ck.20 Fab heavy chain, ... | | Authors: | Kalagiri, R, Stanfield, R.L, Hunter, T, Wilson, I.A. | | Deposit date: | 2023-10-10 | | Release date: | 2025-03-19 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Using phage display for rational engineering of a higher affinity humanized 3' phosphohistidine-specific antibody.
Biorxiv, 2024
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8UHJ
 | | anti-Phosphohistidine Fab hSC44.ck.20.N32F | | Descriptor: | 1,2-ETHANEDIOL, SULFATE ION, hSC44.ck.20.N32F Fab light chain, ... | | Authors: | Kalagiri, R, Stanfield, R.L, Hunter, T, Wilson, I.A. | | Deposit date: | 2023-10-09 | | Release date: | 2025-03-19 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | Using phage display for rational engineering of a higher affinity humanized 3' phosphohistidine-specific antibody.
Biorxiv, 2024
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8UHP
 | | anti-Phosphohistidine Fab hSC44.ck.20.N32F with 3pTZA peptide | | Descriptor: | 1,2-ETHANEDIOL, 3pTza peptide, ACETATE ION, ... | | Authors: | Kalagiri, R, Stanfield, R.L, Hunter, T, Wilson, I.A. | | Deposit date: | 2023-10-09 | | Release date: | 2025-03-19 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Using phage display for rational engineering of a higher affinity humanized 3' phosphohistidine-specific antibody.
Biorxiv, 2024
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8UIO
 | | anti-Phosphohistidine Fab hSC44.ck | | Descriptor: | CITRIC ACID, hSC44.ck Fab heavy chain, hSC44.ck Fab light chain | | Authors: | Kalagiri, R, Stanfield, R.L, Hunter, T, Wilson, I.A. | | Deposit date: | 2023-10-10 | | Release date: | 2025-03-19 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Using phage display for rational engineering of a higher affinity humanized 3' phosphohistidine-specific antibody.
Biorxiv, 2024
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8UHT
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8UHS
 | | anti-Phosphohistidine Fab hSC44.ck.20.elbow bound to phosphate | | Descriptor: | 1,2-ETHANEDIOL, PHOSPHATE ION, hSC44.ck.20.elbow Fab heavy chain, ... | | Authors: | Kalagiri, R, Stanfield, R.L, Hunter, T, Wilson, I.A. | | Deposit date: | 2023-10-09 | | Release date: | 2025-03-19 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Using phage display for rational engineering of a higher affinity humanized 3' phosphohistidine-specific antibody.
Biorxiv, 2024
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8UHN
 | | anti-Phosphohistidine Fab hSC44.ck.20.N32F with 3pHis peptide | | Descriptor: | 1,2-ETHANEDIOL, 3pHis peptide, ACETATE ION, ... | | Authors: | Kalagiri, R, Stanfield, R.L, Hunter, T, Wilson, I.A. | | Deposit date: | 2023-10-09 | | Release date: | 2025-03-19 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | Using phage display for rational engineering of a higher affinity humanized 3' phosphohistidine-specific antibody.
Biorxiv, 2024
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8UIG
 | | anti-Phosphohistidine Fab hSC44.ck.20 with 3pHis peptide | | Descriptor: | 3pHis peptide, hSC44.ck.20 Fab heavy chain, hSC44.ck.20 Fab light chain | | Authors: | Kalagiri, R, Stanfield, R.L, Hunter, T, Wilson, I.A. | | Deposit date: | 2023-10-10 | | Release date: | 2025-03-19 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Using phage display for rational engineering of a higher affinity humanized 3' phosphohistidine-specific antibody.
Biorxiv, 2024
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8UIT
 | | anti-Phosphohistidine Fab hSC44.ck with 3pHis peptide | | Descriptor: | 3pHis peptide, hSC44.ck Fab heavy chain, hSC44.ck Fab light chain | | Authors: | Kalagiri, R, Stanfield, R.L, Hunter, T, Wilson, I.A. | | Deposit date: | 2023-10-10 | | Release date: | 2025-03-19 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Using phage display for rational engineering of a higher affinity humanized 3' phosphohistidine-specific antibody.
Biorxiv, 2024
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8UJI
 | | anti-Phosphohistidine Fab hSC44.ck with 3pTza peptide | | Descriptor: | 1,2-ETHANEDIOL, 3-pTza peptide, hSC44.CK Fab heavy chain, ... | | Authors: | Kalagiri, R, Stanfield, R.L, Hunter, T, Wilson, I.A. | | Deposit date: | 2023-10-11 | | Release date: | 2025-03-19 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Using phage display for rational engineering of a higher affinity humanized 3' phosphohistidine-specific antibody.
Biorxiv, 2024
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7LOP
 | | Crystal structure of SARS-CoV-2 receptor binding domain in complex with antibodies CV05-163 and CR3022 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CR3022 Fab heavy chain, CR3022 Fab light chain, ... | | Authors: | Yuan, M, Zhu, X, Wilson, I.A. | | Deposit date: | 2021-02-10 | | Release date: | 2021-03-03 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.246 Å) | | Cite: | Structural and functional ramifications of antigenic drift in recent SARS-CoV-2 variants.
Science, 373, 2021
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5V7U
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6DCW
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7LMO
 | | Structure of full-length human lambda-6A light chain JTO in complex with stabilizer 34 [3-(2-(7-(diethylamino)-4-methyl-2-oxo-2H-chromen-3-yl)ethyl)-7-(1H-imidazole-5-carbonyl)-1,3,7-triazaspiro[4.4]nonane-2,4-dione] | | Descriptor: | (5~{R})-3-[2-[7-(diethylamino)-4-methyl-2-oxidanylidene-chromen-3-yl]ethyl]-7-(1~{H}-imidazol-4-ylcarbonyl)-1,3,7-triazaspiro[4.4]nonane-2,4-dione, JTO light chain, PHOSPHATE ION | | Authors: | Yan, N.L, Wilson, I.A, Kelly, J.W. | | Deposit date: | 2021-02-05 | | Release date: | 2021-05-19 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (1.99 Å) | | Cite: | Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design.
J.Med.Chem., 64, 2021
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7LMR
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7LMP
 | | Structure of full-length human lambda-6A light chain JTO in complex with stabilizer 36 [3-(2-(7-(diethylamino)-4-methyl-2-oxo-2H-chromen-3-yl)ethyl)-8-(1H-imidazole-4-carbonyl)-1,3,8-triazaspiro[4.5]decane-2,4-dione] | | Descriptor: | 3-[2-[7-(diethylamino)-4-methyl-2-oxidanylidene-chromen-3-yl]ethyl]-8-(1~{H}-imidazol-5-ylcarbonyl)-1,3,8-triazaspiro[4.5]decane-2,4-dione, JTO light chain, PHOSPHATE ION | | Authors: | Yan, N.L, Wilson, I.A, Kelly, J.W. | | Deposit date: | 2021-02-05 | | Release date: | 2021-05-19 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.29 Å) | | Cite: | Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design.
J.Med.Chem., 64, 2021
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7LMQ
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7LMN
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8W3J
 | | Crystal structure of prefusion-stabilized RSV F protein UFCR2-iSS | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Prefusion-stabilized RSV F protein UFCR2-iSS | | Authors: | Lee, Y.Z, Stanfield, R.L, Wilson, I.A, Zhu, J. | | Deposit date: | 2024-02-22 | | Release date: | 2025-01-15 | | Method: | X-RAY DIFFRACTION (2.83 Å) | | Cite: | Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus.
Nat Commun, 15, 2024
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8W3R
 | | Crystal structure of prefusion-stabilized RSV F protein UFCR2-iSS-P2-NQ in complex with A4 single-chain fragment variable | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, A4 single-chain fragment variable, prefusion-stabilized RSV F protein UFCR2-iSS-P2-NQ | | Authors: | Lee, Y.Z, Stanfield, R.L, Wilson, I.A, Zhu, J. | | Deposit date: | 2024-02-22 | | Release date: | 2025-01-15 | | Method: | X-RAY DIFFRACTION (4.02 Å) | | Cite: | Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus.
Nat Commun, 15, 2024
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8W3F
 | | Crystal structure of prefusion-stabilized RSV F protein UFCR1-P2-NQ | | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Prefusion-stabilized RSV F protein UFCR1-P2-NQ | | Authors: | Lee, Y.Z, Stanfield, R.L, Wilson, I.A, Zhu, J. | | Deposit date: | 2024-02-22 | | Release date: | 2025-01-15 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Rational design of uncleaved prefusion-closed trimer vaccines for human respiratory syncytial virus and metapneumovirus.
Nat Commun, 15, 2024
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