7LMO
Structure of full-length human lambda-6A light chain JTO in complex with stabilizer 34 [3-(2-(7-(diethylamino)-4-methyl-2-oxo-2H-chromen-3-yl)ethyl)-7-(1H-imidazole-5-carbonyl)-1,3,7-triazaspiro[4.4]nonane-2,4-dione]
Summary for 7LMO
Entry DOI | 10.2210/pdb7lmo/pdb |
Descriptor | JTO light chain, PHOSPHATE ION, (5~{R})-3-[2-[7-(diethylamino)-4-methyl-2-oxidanylidene-chromen-3-yl]ethyl]-7-(1~{H}-imidazol-4-ylcarbonyl)-1,3,7-triazaspiro[4.4]nonane-2,4-dione, ... (4 entities in total) |
Functional Keywords | amyloidosis, immune system |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 47119.58 |
Authors | Yan, N.L.,Wilson, I.A.,Kelly, J.W. (deposition date: 2021-02-05, release date: 2021-05-19, Last modification date: 2023-10-18) |
Primary citation | Yan, N.L.,Santos-Martins, D.,Nair, R.,Chu, A.,Wilson, I.A.,Johnson, K.A.,Forli, S.,Morgan, G.J.,Petrassi, H.M.,Kelly, J.W. Discovery of Potent Coumarin-Based Kinetic Stabilizers of Amyloidogenic Immunoglobulin Light Chains Using Structure-Based Design. J.Med.Chem., 64:6273-6299, 2021 Cited by PubMed: 33939422DOI: 10.1021/acs.jmedchem.1c00339 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.99 Å) |
Structure validation
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