1R3I
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![BU of 1r3i by Molmil](/molmil-images/mine/1r3i) | potassium channel KcsA-Fab complex in Rb+ | Descriptor: | Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, DIACYL GLYCEROL, ... | Authors: | Zhou, Y, MacKinnon, R. | Deposit date: | 2003-10-02 | Release date: | 2003-11-25 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The occupancy of ions in the K+ selectivity filter: Charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates J.Mol.Biol., 333, 2003
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1R3K
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![BU of 1r3k by Molmil](/molmil-images/mine/1r3k) | potassium channel KcsA-Fab complex in low concentration of Tl+ | Descriptor: | Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, DIACYL GLYCEROL, ... | Authors: | Zhou, Y, MacKinnon, R. | Deposit date: | 2003-10-02 | Release date: | 2003-11-25 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The occupancy of ions in the K+ selectivity filter: Charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates J.Mol.Biol., 333, 2003
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1R3L
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![BU of 1r3l by Molmil](/molmil-images/mine/1r3l) | potassium channel KcsA-Fab complex in Cs+ | Descriptor: | Antibody Fab fragment heavy chain, Antibody Fab fragment light chain, CESIUM ION, ... | Authors: | Zhou, Y, MacKinnon, R. | Deposit date: | 2003-10-02 | Release date: | 2003-11-25 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | The occupancy of ions in the K+ selectivity filter: Charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates J.Mol.Biol., 333, 2003
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3LNM
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![BU of 3lnm by Molmil](/molmil-images/mine/3lnm) | F233W mutant of the Kv2.1 paddle-Kv1.2 chimera channel | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, F233W mutant of the Kv2.1 paddle-Kv1.2 chimera, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Tao, X, Lee, A, Limapichat, W, Dougherty, D.A, MacKinnon, R. | Deposit date: | 2010-02-02 | Release date: | 2010-04-14 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | A gating charge transfer center in voltage sensors. Science, 328, 2010
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3MT5
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![BU of 3mt5 by Molmil](/molmil-images/mine/3mt5) | Crystal Structure of the Human BK Gating Apparatus | Descriptor: | CALCIUM ION, Potassium large conductance calcium-activated channel, subfamily M, ... | Authors: | Yuan, P, MacKinnon, R. | Deposit date: | 2010-04-30 | Release date: | 2010-06-09 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution. Science, 329, 2010
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3ORG
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![BU of 3org by Molmil](/molmil-images/mine/3org) | |
1OTS
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![BU of 1ots by Molmil](/molmil-images/mine/1ots) | Structure of the Escherichia coli ClC Chloride channel and Fab Complex | Descriptor: | CHLORIDE ION, Fab fragment (heavy chain), Fab fragment (light chain), ... | Authors: | Dutzler, R, Campbell, E.B, MacKinnon, R. | Deposit date: | 2003-03-22 | Release date: | 2003-04-15 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | Gating the Selectivity Filter in ClC Chloride Channels Science, 300, 2003
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1OTT
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![BU of 1ott by Molmil](/molmil-images/mine/1ott) | Structure of the Escherichia coli ClC Chloride channel E148A mutant and Fab Complex | Descriptor: | CHLORIDE ION, Fab fragment (Heavy chain), Fab fragment (Light chain), ... | Authors: | Dutzler, R, Campbell, E.B, MacKinnon, R. | Deposit date: | 2003-03-23 | Release date: | 2003-04-15 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Gating the Selectivity Filter in ClC Chloride Channels Science, 300, 2003
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1OTU
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![BU of 1otu by Molmil](/molmil-images/mine/1otu) | Structure of the Escherichia coli ClC Chloride channel E148Q mutant and Fab Complex | Descriptor: | CHLORIDE ION, Fab fragment (Heavy chain), Fab fragment (Light chain), ... | Authors: | Dutzler, R, Campbell, E.B, MacKinnon, R. | Deposit date: | 2003-03-23 | Release date: | 2003-04-15 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Gating the Selectivity Filter in ClC Chloride Channels Science, 300, 2003
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4JTC
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![BU of 4jtc by Molmil](/molmil-images/mine/4jtc) | Crystal structure of Kv1.2-2.1 paddle chimera channel in complex with Charybdotoxin in Cs+ | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, CESIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | Authors: | Banerjee, A, Lee, A, Campbell, E, MacKinnon, R. | Deposit date: | 2013-03-23 | Release date: | 2013-06-12 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel. Elife, 2, 2013
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4JTD
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![BU of 4jtd by Molmil](/molmil-images/mine/4jtd) | Crystal structure of Kv1.2-2.1 paddle chimera channel in complex with Lys27Met mutant of Charybdotoxin | Descriptor: | (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, POTASSIUM ION, ... | Authors: | Banerjee, A, Lee, A, Campbell, E, MacKinnon, R. | Deposit date: | 2013-03-23 | Release date: | 2013-06-12 | Last modified: | 2019-12-25 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel. Elife, 2, 2013
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4KFM
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![BU of 4kfm by Molmil](/molmil-images/mine/4kfm) | |
1KPK
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![BU of 1kpk by Molmil](/molmil-images/mine/1kpk) | Crystal Structure of the ClC Chloride Channel from E. coli | Descriptor: | putative channel transporter | Authors: | Dutzler, R, Campbell, E.B, Cadene, M, Chait, B.T, MacKinnon, R. | Deposit date: | 2001-12-31 | Release date: | 2002-01-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of
anion selectivity. Nature, 415, 2002
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1KPL
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![BU of 1kpl by Molmil](/molmil-images/mine/1kpl) | Crystal Structure of the ClC Chloride Channel from S. typhimurium | Descriptor: | CHLORIDE ION, N-OCTANE, PENTADECANE, ... | Authors: | Dutzler, R, Campbell, E.B, Cadene, M, Chait, B.T, MacKinnon, R. | Deposit date: | 2001-12-31 | Release date: | 2002-01-23 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of
anion selectivity. Nature, 415, 2002
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6B3R
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![BU of 6b3r by Molmil](/molmil-images/mine/6b3r) | Structure of the mechanosensitive channel Piezo1 | Descriptor: | Piezo-type mechanosensitive ion channel component 1, unknown fragment | Authors: | Guo, Y.R, MacKinnon, R. | Deposit date: | 2017-09-22 | Release date: | 2017-12-20 | Last modified: | 2018-05-16 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structure-based membrane dome mechanism for Piezo mechanosensitivity. Elife, 6, 2017
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6CNN
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![BU of 6cnn by Molmil](/molmil-images/mine/6cnn) | |
6XIT
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![BU of 6xit by Molmil](/molmil-images/mine/6xit) | Cryo-EM structure of the G protein-gated inward rectifier K+ channel GIRK2 (Kir3.2) in complex with PIP2 | Descriptor: | G protein-activated inward rectifier potassium channel 2, POTASSIUM ION, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Niu, Y, Tao, X, MacKinnon, R. | Deposit date: | 2020-06-21 | Release date: | 2020-10-07 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM analysis of PIP 2 regulation in mammalian GIRK channels. Elife, 9, 2020
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6C3P
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![BU of 6c3p by Molmil](/molmil-images/mine/6c3p) | Cryo-EM structure of human KATP bound to ATP and ADP in propeller form | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | Authors: | Lee, K.P.K, Chen, J, MacKinnon, R. | Deposit date: | 2018-01-10 | Release date: | 2018-01-24 | Method: | ELECTRON MICROSCOPY (5.6 Å) | Cite: | Molecular structure of human KATP in complex with ATP and ADP. Elife, 6, 2017
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6COY
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![BU of 6coy by Molmil](/molmil-images/mine/6coy) | |
6CNO
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6C3O
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![BU of 6c3o by Molmil](/molmil-images/mine/6c3o) | Cryo-EM structure of human KATP bound to ATP and ADP in quatrefoil form | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 8, ... | Authors: | Lee, K.P.K, Chen, J, MacKinnon, R. | Deposit date: | 2018-01-10 | Release date: | 2018-01-31 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Molecular structure of human KATP in complex with ATP and ADP Elife, 6, 2017
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6CNM
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![BU of 6cnm by Molmil](/molmil-images/mine/6cnm) | Cryo-EM structure of the human SK4/calmodulin channel complex | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, Calmodulin-1, DODECYL-BETA-D-MALTOSIDE, ... | Authors: | Lee, C.H, MacKinnon, R. | Deposit date: | 2018-03-08 | Release date: | 2018-05-02 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures. Science, 360, 2018
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6COZ
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![BU of 6coz by Molmil](/molmil-images/mine/6coz) | |
1AGT
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![BU of 1agt by Molmil](/molmil-images/mine/1agt) | SOLUTION STRUCTURE OF THE POTASSIUM CHANNEL INHIBITOR AGITOXIN 2: CALIPER FOR PROBING CHANNEL GEOMETRY | Descriptor: | AGITOXIN 2 | Authors: | Krezel, A.M, Kasibhatla, C, Hidalgo, P, Mackinnon, R, Wagner, G. | Deposit date: | 1995-04-14 | Release date: | 1995-07-10 | Last modified: | 2017-11-29 | Method: | SOLUTION NMR | Cite: | Solution structure of the potassium channel inhibitor agitoxin 2: caliper for probing channel geometry. Protein Sci., 4, 1995
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1BE9
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![BU of 1be9 by Molmil](/molmil-images/mine/1be9) | THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95 IN COMPLEX WITH A C-TERMINAL PEPTIDE DERIVED FROM CRIPT. | Descriptor: | CRIPT, PSD-95 | Authors: | Doyle, D.A, Lee, A, Lewis, J, Kim, E, Sheng, M, Mackinnon, R. | Deposit date: | 1998-05-20 | Release date: | 1998-10-21 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ. Cell(Cambridge,Mass.), 85, 1996
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