8F4Y
 
 | | Crystal Structure of SARS-CoV-2 2'-O-Methyltransferase in Complex with Compound 5a covalently bound to nsp16 and nsp10 | | Descriptor: | 2'-O-methyltransferase, 4-[(E)-2-(2,4-dichlorophenyl)ethenyl]-6-(trifluoromethyl)pyrimidin-2-ol, 4-[2-(2,4-dichlorophenyl)ethyl]-6-(trifluoromethyl)pyrimidin-2-ol, ... | | Authors: | Minasov, G, Shuvalova, L, Brunzelle, J.S, Rosas-Lemus, M, Kiryukhina, O, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID) | | Deposit date: | 2022-11-11 | | Release date: | 2023-10-18 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.13 Å) | | Cite: | Discovery of a Druggable, Cryptic Pocket in SARS-CoV-2 nsp16 Using Allosteric Inhibitors.
Acs Infect Dis., 9, 2023
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8F4S
 | | Crystal Structure of the SARS-CoV-2 2'-O-Methyltransferase with Compound 5a bound to the Cryptic Pocket of nsp16 | | Descriptor: | 2'-O-methyltransferase, 4-[(E)-2-(2,4-dichlorophenyl)ethenyl]-6-(trifluoromethyl)pyrimidin-2-ol, FORMIC ACID, ... | | Authors: | Minasov, G, Shuvalova, L, Brunzelle, J.S, Rosas-Lemus, M, Kiryukhina, O, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID) | | Deposit date: | 2022-11-11 | | Release date: | 2023-10-18 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Discovery of a Druggable, Cryptic Pocket in SARS-CoV-2 nsp16 Using Allosteric Inhibitors.
Acs Infect Dis., 9, 2023
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8FXW
 | | Cryo-EM structure of cowpox virus M2 in complex with human B7.1 (hexameric ring) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CPXV040 protein, T-lymphocyte activation antigen CD80 | | Authors: | Elliott, J.I, Adams, L.J, Nelson, C.A, Fremont, D.H, CSBID, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2023-01-25 | | Release date: | 2025-02-05 | | Last modified: | 2025-03-19 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structure basis of poxvirus mediated sabotage of T-cell costimulation
To Be Published
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8FXZ
 | | Cryo-EM structure of cowpox virus M2 in complex with human B7.1 (heptameric ring) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CPXV040 protein, T-lymphocyte activation antigen CD80 | | Authors: | Elliott, J.I, Adams, L.J, Nelson, C.A, Fremont, D.H, CSBID | | Deposit date: | 2023-01-25 | | Release date: | 2025-02-05 | | Last modified: | 2025-03-19 | | Method: | ELECTRON MICROSCOPY (2.86 Å) | | Cite: | Structure basis of poxvirus mediated sabotage of T-cell costimulation
To Be Published
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8FXY
 | | Cryo-EM structure of cowpox virus M2 in complex with human B7.2 (hexameric ring) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CPXV040 protein, T-lymphocyte activation antigen CD86 | | Authors: | Elliott, J.I, Adams, L.J, Nelson, C.A, Fremont, D.H, CSBID | | Deposit date: | 2023-01-25 | | Release date: | 2025-02-05 | | Last modified: | 2025-03-19 | | Method: | ELECTRON MICROSCOPY (3.34 Å) | | Cite: | Structure basis of poxvirus mediated sabotage of T-cell costimulation
To Be Published
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8FXX
 | | Cryo-EM structure of cowpox virus M2 in complex with human B7.2 (heptameric ring) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CPXV040 protein, T-lymphocyte activation antigen CD86 | | Authors: | Elliott, J.I, Adams, L.J, Nelson, C.A, Fremont, D.H, CSBID | | Deposit date: | 2023-01-25 | | Release date: | 2025-02-05 | | Last modified: | 2025-03-19 | | Method: | ELECTRON MICROSCOPY (3.26 Å) | | Cite: | Structure basis of poxvirus mediated sabotage of T-cell costimulation
To Be Published
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9AVI
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9BHC
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9BHE
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9BIZ
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9BJ0
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9BIY
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9CLY
 | | Crystal structure of the 3-ketoacyl-(acyl-carrier-protein) reductase, CylG, from Streptococcus agalactiae 2603V/R | | Descriptor: | CylG protein, IMIDAZOLE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Maltseva, N, Kim, Y, Endres, M, Joachimiak, A, Center for Structural Biology of Infectious Diseases (CSBID) | | Deposit date: | 2024-07-12 | | Release date: | 2024-07-24 | | Method: | X-RAY DIFFRACTION (2.16 Å) | | Cite: | Crystal structure of the 3-ketoacyl-(acyl-carrier-protein) reductase, CylG, from Streptococcus agalactiae 2603V/R
To be published
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9D5W
 | | Crystal Structure of the Substrate Binding Domain Protein of the ABC Transporter PBP2_YxeM from Vibrio cholerae | | Descriptor: | Amino acid ABC transporter, periplasmic amino acid-binding portion, CHLORIDE ION, ... | | Authors: | Kim, Y, Maltseva, N, Grimshaw, S, Joachimiak, A, Center for Structural Biology of Infectious Diseases (CSBID) | | Deposit date: | 2024-08-14 | | Release date: | 2024-08-28 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal Structure of the Substrate Binding Domain Protein of the ABC Transporter PBP2_YxeM from Vibrio cholerae
To Be Published
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9DDY
 | | The Crystal Structure of Geranyltranstransferase from Streptococcus pneumoniae TIGR4 | | Descriptor: | GLYCEROL, Geranyltranstransferase | | Authors: | Kim, Y, Tan, A, Endres, M, Tan, K, Joachimik, A, Center for Structural Biology of Infectious Diseases (CSBID) | | Deposit date: | 2024-08-28 | | Release date: | 2024-09-18 | | Method: | X-RAY DIFFRACTION (2.32 Å) | | Cite: | The Crystal Structure of Geranyltranstransferase from Streptococcus pneumoniae TIGR4
To Be Published
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9D91
 | | Crystal structure of L-asparaginase from Streptococcus pneumoniae TIGR4 | | Descriptor: | 1,2-ETHANEDIOL, Asparaginase, SULFATE ION | | Authors: | Gade, P, Endres, M, Babnigg, G, Joachimiak, A, Center for Structural Biology of Infectious Diseases (CSBID) | | Deposit date: | 2024-08-20 | | Release date: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | Crystal structure of L-asparaginase from
Streptococcus pneumoniae TIGR4
To Be Published
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9EDY
 | | Crystal structure of Yck2 from Candida albicans in complex with inhibitor 2b: 6-fluoro-2-(4-fluorophenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyridine | | Descriptor: | 6-fluoro-2-(4-fluorophenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyridine, CHLORIDE ION, non-specific serine/threonine protein kinase | | Authors: | Stogios, P.J, Whitesell, L, Cowen, L.E, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID) | | Deposit date: | 2024-11-18 | | Release date: | 2025-01-08 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of Yck2 from Candida albicans in complex with inhibitor 2b: 6-fluoro-2-(4-fluorophenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyridine
To Be Published
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9EDV
 | | Crystal structure of Yck2 from Candida albicans in complex with inhibitor 1e: 2-(4-fluorophenyl)-3-(pyridin-4-yl)imidazo[1,2-a]pyridine-7-carbonitrile | | Descriptor: | 2-(4-fluorophenyl)-3-(pyridin-4-yl)imidazo[1,2-a]pyridine-7-carbonitrile, CHLORIDE ION, non-specific serine/threonine protein kinase | | Authors: | Stogios, P.J, Whitesell, L, Cowen, L.E, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID) | | Deposit date: | 2024-11-18 | | Release date: | 2025-01-08 | | Method: | X-RAY DIFFRACTION (2.42 Å) | | Cite: | Crystal structure of Yck2 from Candida albicans in complex with inhibitor 1e: 2-(4-fluorophenyl)-3-(pyridin-4-yl)imidazo[1,2-a]pyridine-7-carbonitrile
To Be Published
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9EDX
 | | Crystal structure of Yck2 from Candida albicans in complex with inhibitor 2a: 2-(4-fluorophenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyridine-6-carbonitrile | | Descriptor: | 2-(4-fluorophenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyridine-6-carbonitrile, CHLORIDE ION, non-specific serine/threonine protein kinase | | Authors: | Stogios, P.J, Whitesell, L, Cowen, L.E, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID) | | Deposit date: | 2024-11-18 | | Release date: | 2025-01-08 | | Method: | X-RAY DIFFRACTION (2.03 Å) | | Cite: | Crystal structure of Yck2 from Candida albicans in complex with inhibitor 2a: 2-(4-fluorophenyl)-3-(pyridin-4-yl)pyrazolo[1,5-a]pyridine-6-carbonitrile
To Be Published
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9EDW
 | | Crystal structure of Yck2 from Candida albicans in complex with inhibitor 1f: 7-fluoro-2-(4-fluorophenyl)-3-(pyridin-4-yl)imidazo[1,2-a]pyridine | | Descriptor: | 7-fluoro-2-(4-fluorophenyl)-3-(pyridin-4-yl)imidazo[1,2-a]pyridine, CHLORIDE ION, Non-specific serine/threonine protein kinase | | Authors: | Stogios, P.J, Whitesell, L, Cowen, L.E, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Biology of Infectious Diseases (CSBID) | | Deposit date: | 2024-11-18 | | Release date: | 2025-01-08 | | Method: | X-RAY DIFFRACTION (2.33 Å) | | Cite: | Crystal structure of Yck2 from Candida albicans in complex with inhibitor 1f: 7-fluoro-2-(4-fluorophenyl)-3-(pyridin-4-yl)imidazo[1,2-a]pyridine
To Be Published
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9BZB
 | | Crystal structure of metallo-hydrolase-like_MBL-fold protein from Salmonella typhimurium LT2 | | Descriptor: | 1,2-ETHANEDIOL, FORMIC ACID, SULFATE ION, ... | | Authors: | Kim, Y, Maltseva, N, Endres, M, Joachimiak, A, Center for Structural Biology of Infectious Diseases (CSBID) | | Deposit date: | 2024-05-24 | | Release date: | 2024-06-05 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Crystal structure of metallo-hydrolase-like_MBL-fold protein from Salmonella typhimurium LT2
To Be Published
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9BZQ
 | | Structure of Class A Beta-lactamase from Bordetella bronchiseptica RB50 in a complex with Avibactam | | Descriptor: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, 1,2-ETHANEDIOL, FORMIC ACID, ... | | Authors: | Maltseva, N, Kim, Y, Endres, M, Joachimiak, A, Center for Structural Biology of Infectious Diseases (CSBID) | | Deposit date: | 2024-05-24 | | Release date: | 2024-06-12 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.47 Å) | | Cite: | Structure of Class A Beta-lactamase from Bordetella bronchiseptica RB50 in a complex with Avibactam
To Be Published
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9BZN
 | | High resolution structure of class A Beta-lactamase from Bordetella bronchiseptica RB50 | | Descriptor: | FORMIC ACID, SULFATE ION, class A Beta-lactamase, ... | | Authors: | Maltseva, N, Kim, Y, Endres, M, Joachimiak, A, Center for Structural Biology of Infectious Diseases (CSBID) | | Deposit date: | 2024-05-24 | | Release date: | 2024-06-12 | | Method: | X-RAY DIFFRACTION (1.05 Å) | | Cite: | High resolution structure of class A Beta-lactamase from Bordetella bronchiseptica RB50
To Be Published
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9BZR
 | | Structure of Class A Beta-lactamase from Bordetella bronchiseptica RB50 in a complex with clavulonate | | Descriptor: | CHLORIDE ION, MALONIC ACID, N-(2-HYDROXY-4-OXO-BUTYL)-N-(3-OXO-TRANSPROPENYL)AMINE, ... | | Authors: | Maltseva, N, Kim, Y, Endres, M, Joachimiak, A, Center for Structural Biology of Infectious Diseases (CSBID) | | Deposit date: | 2024-05-24 | | Release date: | 2024-06-12 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Structure of Class A Beta-lactamase from Bordetella bronchiseptica RB50 in a complex with clavulonate
To Be Published
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9DRS
 | | Crystal structure of M. tuberculosis PheRS-tRNA complex bound to inhibitor D-116 | | Descriptor: | 1,2-ETHANEDIOL, 1H-benzimidazol-2-amine, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | Authors: | Gade, P, Chang, C, Forte, B, Wower, J, Gilbert, I.H, Baragana, B, Michalska, K, Joachimiak, A, Center for Structural Biology of Infectious Diseases (CSBID) | | Deposit date: | 2024-09-26 | | Release date: | 2025-02-12 | | Last modified: | 2025-02-19 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Different chemical scaffolds bind to L-phe site in Mycobacterium tuberculosis Phe-tRNA synthetase.
Eur.J.Med.Chem., 287, 2025
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