8F4Y

Crystal Structure of SARS-CoV-2 2'-O-Methyltransferase in Complex with Compound 5a covalently bound to nsp16 and nsp10

Summary for 8F4Y

• Entry DOI: 10.2210/pdb8f4y/pdb
• Descriptor: 2'-O-methyltransferase, Non-structural protein 10, SODIUM ION, ... (8 entities in total)
• Functional Keywords: csbid, structural genomics, center for structural biology of infectious diseases, nsp16-10, 2'-o-methyltransferase, transferase
• Biological source: Severe acute respiratory syndrome coronavirus 2; More
• Total number of polymer chains: 2
• Total formula weight: 50686.23

Authors

Minasov, G.,Shuvalova, L.,Brunzelle, J.S.,Rosas-Lemus, M.,Kiryukhina, O.,Satchell, K.J.F.,Center for Structural Biology of Infectious Diseases (CSBID) (deposition date: 2022-11-11, release date: 2023-10-18, Last modification date: 2023-10-25)

• Primary citation: Inniss, N.L.,Kozic, J.,Li, F.,Rosas-Lemus, M.,Minasov, G.,Rybacek, J.,Zhu, Y.,Pohl, R.,Shuvalova, L.,Rulisek, L.,Brunzelle, J.S.,Bednarova, L.,Stefek, M.,Kormanik, J.M.,Andris, E.,Sebestik, J.,Li, A.S.M.,Brown, P.J.,Schmitz, U.,Saikatendu, K.,Chang, E.,Nencka, R.,Vedadi, M.,Satchell, K.J.F.; Discovery of a Druggable, Cryptic Pocket in SARS-CoV-2 nsp16 Using Allosteric Inhibitors.; Acs Infect Dis., 9:1918-1931, 2023; PubMed: 37728236; DOI: 10.1021/acsinfecdis.3c00203

Experimental method

X-RAY DIFFRACTION (2.13 Å)