8F09

Crystal structure of a trimethoprim-resistant dihydrofolate reductase (DHFR) enzyme from an uncultured soil bacterium

Summary for 8F09

• Entry DOI: 10.2210/pdb8f09/pdb
• Descriptor: Dihydrofolate reductase, SULFATE ION (3 entities in total)
• Functional Keywords: structural genomics, center for structural biology of infectious diseases, csbid, oxidoreductase, antimicrobial resistance, antibiotic resistance, trimethoprim, dhfr, dihydrofolate reductase
• Biological source: uncultured bacterium
• Total number of polymer chains: 2
• Total formula weight: 38932.13

Authors

Stogios, P.J.,Evdokimova, D.,Borek, D.,Di Leo, R.,Semper, C.,Savchenko, A.,Joachimiak, A.,Satchell, K.J.F.,Center for Structural Biology of Infectious Diseases (CSBID) (deposition date: 2022-11-02, release date: 2022-11-16, Last modification date: 2023-10-25)

• Primary citation: Stogios, P.J.; Crystal structure of a trimethoprim-resistant dihydrofolate reductase (DHFR) enzyme from an uncultured soil bacterium; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.45 Å)