8F09

Crystal structure of a trimethoprim-resistant dihydrofolate reductase (DHFR) enzyme from an uncultured soil bacterium

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004146	molecular_function	dihydrofolate reductase activity
A	0006730	biological_process	one-carbon metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0042398	biological_process	modified amino acid biosynthetic process
A	0042559	biological_process	pteridine-containing compound biosynthetic process
A	0043168	molecular_function	anion binding
A	0044281	biological_process	small molecule metabolic process
A	0046452	biological_process	dihydrofolate metabolic process
A	0046654	biological_process	tetrahydrofolate biosynthetic process
A	0046655	biological_process	folic acid metabolic process
A	0050661	molecular_function	NADP binding
B	0004146	molecular_function	dihydrofolate reductase activity
B	0006730	biological_process	one-carbon metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0042398	biological_process	modified amino acid biosynthetic process
B	0042559	biological_process	pteridine-containing compound biosynthetic process
B	0043168	molecular_function	anion binding
B	0044281	biological_process	small molecule metabolic process
B	0046452	biological_process	dihydrofolate metabolic process
B	0046654	biological_process	tetrahydrofolate biosynthetic process
B	0046655	biological_process	folic acid metabolic process
B	0050661	molecular_function	NADP binding

Functional Information from PROSITE/UniProt

site_id	PS00075
Number of Residues	23
Details	DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGksndLPWhlpd.DmkyFmqtT

Chain	Residue	Details
A	VAL14-THR36

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