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8F09

Crystal structure of a trimethoprim-resistant dihydrofolate reductase (DHFR) enzyme from an uncultured soil bacterium

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
Dihydrofolate reductasepolymer16719225.92UniProt (A0A8A1VA22)
Pfam (PF00186)
uncultured bacteriumDHFR
2C, D, E, F, G
(A, B)
SULFATE IONnon-polymer96.15Chemie (SO4)
3H, I
(A, B)
waterwater18.072Chemie (HOH)
Sequence modifications
A, B: 1 - 166 (UniProt: A0A8A1VA22)
PDBExternal DatabaseDetails
Gly 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains2
Total formula weight38451.8
Non-Polymers*Number of molecules5
Total formula weight480.3
All*Total formula weight38932.1
*Water molecules are not included.

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PDB entries from 2025-06-11

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