2Y62
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![BU of 2y62 by Molmil](/molmil-images/mine/2y62) | Crystal structure of Leishmanial E65Q-TIM complexed with R-Glycidol phosphate | Descriptor: | GLYCEROL, SN-GLYCEROL-1-PHOSPHATE, SN-GLYCEROL-3-PHOSPHATE, ... | Authors: | Venkatesan, R, Alahuhta, M, Pihko, P.M, Wierenga, R.K. | Deposit date: | 2011-01-19 | Release date: | 2011-12-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.08 Å) | Cite: | High Resolution Crystal Structures of Triosephosphate Isomerase Complexed with its Suicide Inhibitors: The Conformational Flexibility of the Catalytic Glutamate in its Closed, Liganded Active Site. Protein Sci., 20, 2011
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2Y63
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![BU of 2y63 by Molmil](/molmil-images/mine/2y63) | Crystal structure of Leishmanial E65Q-TIM complexed with Bromohydroxyacetone phosphate | Descriptor: | (3-bromo-2-oxo-propoxy)phosphonic acid, TRIOSEPHOSPHATE ISOMERASE | Authors: | Venkatesan, R, Alahuhta, M, Pihko, P.M, Wierenga, R.K. | Deposit date: | 2011-01-19 | Release date: | 2011-12-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | High Resolution Crystal Structures of Triosephosphate Isomerase Complexed with its Suicide Inhibitors: The Conformational Flexibility of the Catalytic Glutamate in its Closed, Liganded Active Site. Protein Sci., 20, 2011
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3BJ5
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![BU of 3bj5 by Molmil](/molmil-images/mine/3bj5) | Alternative conformations of the x region of human protein disulphide-isomerase modulate exposure of the substrate binding b' domain | Descriptor: | Protein disulfide-isomerase, SULFATE ION | Authors: | Ruddock, L.W, Nguyen, V.D, Wierenga, R.K, Haapalainen, A.M. | Deposit date: | 2007-12-03 | Release date: | 2008-09-30 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Alternative conformations of the x region of human protein disulphide-isomerase modulate exposure of the substrate binding b' domain J.Mol.Biol., 383, 2008
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1WL5
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![BU of 1wl5 by Molmil](/molmil-images/mine/1wl5) | Human cytosolic acetoacetyl-CoA thiolase | Descriptor: | GLYCEROL, SULFATE ION, acetyl-Coenzyme A acetyltransferase 2 | Authors: | Kursula, P, Fukao, T, Kondo, N, Wierenga, R.K. | Deposit date: | 2004-06-20 | Release date: | 2005-03-01 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | High Resolution Crystal Structures of Human Cytosolic Thiolase (CT): A Comparison of the Active Sites of Human CT, Bacterial Thiolase, and Bacterial KAS I J.Mol.Biol., 347, 2005
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6EVO
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![BU of 6evo by Molmil](/molmil-images/mine/6evo) | Crystal structure the peptide-substrate-binding domain of human type II collagen prolyl 4-hydroxylase complexed with Pro-Pro-Gly-Pro-Arg-Gly-Pro-Pro-Gly. | Descriptor: | DIMETHYL SULFOXIDE, PRO-PRO-GLY-PRO-ARG-GLY-PRO-PRO-GLY, Prolyl 4-hydroxylase subunit alpha-2, ... | Authors: | Murthy, A.V, Sulu, R, Koski, M.K, Wierenga, R.K. | Deposit date: | 2017-11-02 | Release date: | 2018-09-12 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural enzymology binding studies of the peptide-substrate-binding domain of human collagen prolyl 4-hydroxylase (type-II): High affinity peptides have a PxGP sequence motif. Protein Sci., 27, 2018
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6EVM
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![BU of 6evm by Molmil](/molmil-images/mine/6evm) | Crystal structure of a Pro-9 complexed peptide-substrate-binding domain of human type II collagen prolyl 4-hydroxylase | Descriptor: | DIMETHYL SULFOXIDE, Pro-9, Prolyl 4-hydroxylase subunit alpha-2, ... | Authors: | Murthy, A.V, Sulu, R, Koski, M.K, Wierenga, R.K. | Deposit date: | 2017-11-02 | Release date: | 2018-09-12 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural enzymology binding studies of the peptide-substrate-binding domain of human collagen prolyl 4-hydroxylase (type-II): High affinity peptides have a PxGP sequence motif. Protein Sci., 27, 2018
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6EVN
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![BU of 6evn by Molmil](/molmil-images/mine/6evn) | Crystal structure of peptide-substrate-binding domain of human type II collagen prolyl 4-hydroxylase complex with Pro-Pro-Gly-Pro-Ala-Gly-Pro-Pro-Gly. | Descriptor: | DIMETHYL SULFOXIDE, PRO-PRO-GLY-PRO-ALA-GLY-PRO-PRO-GLY, Prolyl 4-hydroxylase subunit alpha-2, ... | Authors: | Murthy, A.V, Sulu, R, Koski, M.K, Wierenga, R.K. | Deposit date: | 2017-11-02 | Release date: | 2018-09-12 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Structural enzymology binding studies of the peptide-substrate-binding domain of human collagen prolyl 4-hydroxylase (type-II): High affinity peptides have a PxGP sequence motif. Protein Sci., 27, 2018
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6EVL
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![BU of 6evl by Molmil](/molmil-images/mine/6evl) | Crystal structure of an unlignaded peptide-substrate-binding domain of human type II collagen prolyl 4-hydroxylase | Descriptor: | DIMETHYL SULFOXIDE, GLYCINE, Prolyl 4-hydroxylase subunit alpha-2, ... | Authors: | Murthy, A.V, Sulu, R, Koski, M.K, Wierenga, R.K. | Deposit date: | 2017-11-02 | Release date: | 2018-09-12 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Structural enzymology binding studies of the peptide-substrate-binding domain of human collagen prolyl 4-hydroxylase (type-II): High affinity peptides have a PxGP sequence motif. Protein Sci., 27, 2018
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6EVP
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![BU of 6evp by Molmil](/molmil-images/mine/6evp) | Crystal structure the peptide-substrate-binding domain of human type II collagen prolyl 4-hydroxylase complexed with Pro-Pro-Gly-Pro-Glu-Gly-Pro-Pro-Gly. | Descriptor: | DIMETHYL SULFOXIDE, PRO-PRO-GLY-PRO-GLU-GLY-PRO-PRO-GLY, Prolyl 4-hydroxylase subunit alpha-2, ... | Authors: | Murthy, A.V, Sulu, R, Koski, M.K, Wierenga, R.K. | Deposit date: | 2017-11-02 | Release date: | 2018-09-12 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.68 Å) | Cite: | Structural enzymology binding studies of the peptide-substrate-binding domain of human collagen prolyl 4-hydroxylase (type-II): High affinity peptides have a PxGP sequence motif. Protein Sci., 27, 2018
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1ZCJ
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![BU of 1zcj by Molmil](/molmil-images/mine/1zcj) | |
1X74
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![BU of 1x74 by Molmil](/molmil-images/mine/1x74) | Alpha-methylacyl-CoA racemase from Mycobacterium tuberculosis- mutational and structural characterization of the fold and active site | Descriptor: | 2-methylacyl-CoA racemase, GLYCEROL, PHOSPHATE ION | Authors: | Kalle, S, Bhaumik, P, Schmitz, W, Kotti, T.J, Conzelmann, E, Wierenga, R.K, Hiltunen, J.K. | Deposit date: | 2004-08-13 | Release date: | 2005-01-18 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | {alpha}-Methylacyl-CoA Racemase from Mycobacterium tuberculosis: MUTATIONAL AND STRUCTURAL CHARACTERIZATION OF THE ACTIVE SITE AND THE FOLD J.Biol.Chem., 280, 2005
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5AB6
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![BU of 5ab6 by Molmil](/molmil-images/mine/5ab6) | |
5AB4
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![BU of 5ab4 by Molmil](/molmil-images/mine/5ab4) | |
5AB5
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![BU of 5ab5 by Molmil](/molmil-images/mine/5ab5) | |
5AB7
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![BU of 5ab7 by Molmil](/molmil-images/mine/5ab7) | |
3GZE
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![BU of 3gze by Molmil](/molmil-images/mine/3gze) | |
4C2J
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![BU of 4c2j by Molmil](/molmil-images/mine/4c2j) | Crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase in complex with CoA | Descriptor: | 1,2-ETHANEDIOL, 3-KETOACYL-COA THIOLASE, MITOCHONDRIAL, ... | Authors: | Kiema, T.-R, Harijan, R.K, Wierenga, R.K. | Deposit date: | 2013-08-19 | Release date: | 2014-09-03 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Crystal Structure of Human Mitochondrial 3-Ketoacyl-Coa Thiolase (T1): Insight Into the Reaction Mechanism of its Thiolase and Thioesterase Activities Acta Crystallogr.,Sect.D, 70, 2014
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4C2K
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![BU of 4c2k by Molmil](/molmil-images/mine/4c2k) | Crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase | Descriptor: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | Authors: | Kiema, T.-R, Harijan, R.K, Wierenga, R.K. | Deposit date: | 2013-08-19 | Release date: | 2014-09-03 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The Crystal Structure of Human Mitochondrial 3-Ketoacyl-Coa Thiolase (T1): Insight Into the Reaction Mechanism of its Thiolase and Thioesterase Activities Acta Crystallogr.,Sect.D, 70, 2014
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4BI9
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![BU of 4bi9 by Molmil](/molmil-images/mine/4bi9) | Crystal structure of wild-type SCP2 thiolase from Trypanosoma brucei. | Descriptor: | 3-KETOACYL-COA THIOLASE, PUTATIVE | Authors: | Harijan, R.K, Kiema, T.-R, Weiss, M.S, Michels, P.A.M, Wierenga, R.K. | Deposit date: | 2013-04-10 | Release date: | 2013-08-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Crystal Structures of Scp2-Thiolases of Trypanosomatidae, Human Pathogens Causing Widespread Tropical Diseases: The Importance for Catalysis of the Cysteine of the Unique Hdcf Loop. Biochem.J., 455, 2013
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4BIA
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![BU of 4bia by Molmil](/molmil-images/mine/4bia) | Crystal structure of SCP2 thiolase from Trypanosoma brucei: The C337A mutant. | Descriptor: | 3-KETOACYL-COA THIOLASE, PUTATIVE | Authors: | Harijan, R.K, Kiema, T.-R, Weiss, M.S, Michels, P.A.M, Wierenga, R.K. | Deposit date: | 2013-04-10 | Release date: | 2013-08-14 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal Structures of Scp2-Thiolases of Trypanosomatidae, Human Pathogens Causing Widespread Tropical Diseases: The Importance for Catalysis of the Cysteine of the Unique Hdcf Loop. Biochem.J., 455, 2013
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4EGV
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![BU of 4egv by Molmil](/molmil-images/mine/4egv) | |
1HNU
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![BU of 1hnu by Molmil](/molmil-images/mine/1hnu) | CRYSTAL STRUCTURE OF PEROXISOMAL DELTA3-DELTA2-ENOYL-COA ISOMERASE FROM SACCHAROMYCES CEREVISIAE | Descriptor: | 1,2-ETHANEDIOL, D3,D2-ENOYL COA ISOMERASE ECI1, PERRHENATE | Authors: | Mursula, A.M, van Aalten, D.M.F, Hiltunen, J.K, Wierenga, R.K. | Deposit date: | 2000-12-08 | Release date: | 2001-06-20 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | The crystal structure of delta(3)-delta(2)-enoyl-CoA isomerase. J.Mol.Biol., 309, 2001
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1HNO
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![BU of 1hno by Molmil](/molmil-images/mine/1hno) | CRYSTAL STRUCTURE OF PEROXISOMAL DELTA3-DELTA2-ENOYL-COA ISOMERASE FROM SACCHAROMYCES CEREVISIAE | Descriptor: | 1,2-ETHANEDIOL, D3,D2-ENOYL COA ISOMERASE ECI1 | Authors: | Mursula, A.M, van Aalten, D.M.F, Hiltunen, J.K, Wierenga, R.K. | Deposit date: | 2000-12-08 | Release date: | 2001-06-20 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The crystal structure of delta(3)-delta(2)-enoyl-CoA isomerase. J.Mol.Biol., 309, 2001
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6TP5
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![BU of 6tp5 by Molmil](/molmil-images/mine/6tp5) | Crystal structure of human Transmembrane prolyl 4-hydroxylase | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ... | Authors: | Myllykoski, M, Sutinen, A, Koski, M.K, Kallio, J.P, Raasakka, A, Myllyharju, J, Wierenga, R.K, Koivunen, P. | Deposit date: | 2019-12-12 | Release date: | 2020-12-23 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains. J.Biol.Chem., 296, 2020
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7QNI
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![BU of 7qni by Molmil](/molmil-images/mine/7qni) | CRYSTAL STRUCTURE OF E.coli ALCOHOL DEHYDROGENASE - FucO MUTANT L259V | Descriptor: | CITRIC ACID, Lactaldehyde reductase | Authors: | Sridhar, S, Kiema, T.R, Wierenga, R.K, Widersten, M. | Deposit date: | 2021-12-20 | Release date: | 2022-10-19 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Structures of lactaldehyde reductase, FucO, link enzyme activity to hydrogen bond networks and conformational dynamics. Febs J., 290, 2023
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