4C2J
Crystal structure of human mitochondrial 3-ketoacyl-CoA thiolase in complex with CoA
Summary for 4C2J
Entry DOI | 10.2210/pdb4c2j/pdb |
Related | 4C2K |
Descriptor | 3-KETOACYL-COA THIOLASE, MITOCHONDRIAL, 1,2-ETHANEDIOL, COENZYME A, ... (4 entities in total) |
Functional Keywords | transferase, fatty acid metabolism, mitochondrial beta-oxidation, thiolytic cleavage |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Mitochondrion : P42765 |
Total number of polymer chains | 4 |
Total formula weight | 180708.90 |
Authors | Kiema, T.-R.,Harijan, R.K.,Wierenga, R.K. (deposition date: 2013-08-19, release date: 2014-09-03, Last modification date: 2023-12-20) |
Primary citation | Kiema, T.-R.,Harijan, R.K.,Strozyk, M.,Fukao, T.,Alexson, S.E.H.,Wierenga, R.K. The Crystal Structure of Human Mitochondrial 3-Ketoacyl-Coa Thiolase (T1): Insight Into the Reaction Mechanism of its Thiolase and Thioesterase Activities Acta Crystallogr.,Sect.D, 70:3212-, 2014 Cited by PubMed: 25478839DOI: 10.1107/S1399004714023827 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
Download full validation report